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Protein

Metallocarboxypeptidase inhibitor

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tightly binding, competitive inhibitor of different types of pancreatic-like carboxypeptidases.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Protein family/group databases

MEROPSiI46.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallocarboxypeptidase inhibitor
Alternative name(s):
Leech carboxypeptidase inhibitor
Short name:
LCI
OrganismiHirudo medicinalis (Medicinal leech)
Taxonomic identifieri6421 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudinidaHirudineaArhynchobdellidaHirudiniformesHirudinidaeHirudo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15151 PublicationAdd
BLAST
Chaini16 – 8166Metallocarboxypeptidase inhibitorPRO_0000026725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 48
Disulfide bondi32 ↔ 76
Disulfide bondi33 ↔ 57
Disulfide bondi36 ↔ 72

Keywords - PTMi

Disulfide bond

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei80 – 801Interaction with carboxypeptidaseBy similarity

Protein-protein interaction databases

MINTiMINT-125639.

Structurei

Secondary structure

1
81
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 266Combined sources
Beta strandi31 – 388Combined sources
Helixi43 – 453Combined sources
Beta strandi47 – 504Combined sources
Helixi55 – 606Combined sources
Beta strandi65 – 673Combined sources
Beta strandi70 – 778Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DTDX-ray1.65B20-80[»]
1DTVNMR-A16-81[»]
1ZFINMR-A16-81[»]
1ZFLNMR-A16-81[»]
2ABZX-ray2.16C/D/E/F16-81[»]
ProteinModelPortaliP81511.
SMRiP81511. Positions 16-81.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81511.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.1040.10. 1 hit.
InterProiIPR024063. Prot_inh_LCI.
[Graphical view]
SUPFAMiSSF57620. SSF57620. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLVFLCCL HLVISSHTPD ESFLCYQPDQ VCCFICRGAA PLPSEGECNP
60 70 80
HPTAPWCREG AVEWVPYSTG QCRTTCIPYV E
Length:81
Mass (Da):9,068
Last modified:July 15, 1999 - v1
Checksum:i7D7E175E6933922A
GO

Mass spectrometryi

Molecular mass is 7326 Da from positions 16 - 81. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010948 mRNA. Translation: CAA09422.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010948 mRNA. Translation: CAA09422.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DTDX-ray1.65B20-80[»]
1DTVNMR-A16-81[»]
1ZFINMR-A16-81[»]
1ZFLNMR-A16-81[»]
2ABZX-ray2.16C/D/E/F16-81[»]
ProteinModelPortaliP81511.
SMRiP81511. Positions 16-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-125639.

Protein family/group databases

MEROPSiI46.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP81511.

Family and domain databases

Gene3Di3.30.1040.10. 1 hit.
InterProiIPR024063. Prot_inh_LCI.
[Graphical view]
SUPFAMiSSF57620. SSF57620. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCPI_HIRME
AccessioniPrimary (citable) accession number: P81511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.