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P81461 (CONA_CANCT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Concanavalin-A

Short name=Con A
OrganismCanavalia cathartica (Jackbean) (Canavalia virosa)
Taxonomic identifier28958 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glucose/D-mannose specific lectin.

Subunit structure

Homotetramer.

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Sequence similarities

Belongs to the leguminous lectin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Concanavalin-A
PRO_0000105088

Regions

Region99 – 1002Carbohydrate binding By similarity

Sites

Metal binding81Manganese
Metal binding101Calcium
Metal binding101Manganese
Metal binding121Calcium; via carbonyl oxygen
Metal binding141Calcium
Metal binding191Calcium
Metal binding191Manganese
Metal binding241Manganese
Metal binding2081Calcium By similarity
Binding site121Carbohydrate By similarity
Binding site2281Carbohydrate; via amide nitrogen By similarity

Secondary structure

......................................... 237
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P81461 [UniParc].

Last modified December 15, 1998. Version 1.
Checksum: DD31D2BFCC6EDD07

FASTA23725,539
        10         20         30         40         50         60 
ADTIVAVELD TYPNTDIGDP SYPHIGIDIK SVRSKKTAKW NMQNGKVGTA HIIYNSVGKR 

        70         80         90        100        110        120 
LSAVVSYPNG DSATVSYDVD LDNVLPEWVR VGLSASTGLY KETNTILSWS FTSKLKSNST 

       130        140        150        160        170        180 
HETNALHFMF NQFSKDQKDL ILQGDATTGT DGNLELTRVS SNGSPQGNSV GRALFYAPVH 

       190        200        210        220        230 
IWESSAVVAS FDATFTFLIK SPDSHPADGI AFFISNIDSS IPSGSTGRLL GLFPDAN 

« Hide

References

[1]"Primary structures of concanavalin A-like lectins from seeds of two species of Canavalia."
Fujimura S., Terada S., Jayavardhanan K.K., Panikkar K.R., Kimoto E.
Phytochemistry 33:985-987(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths."
Mueller-Dieckmann C., Panjikar S., Schmidt A., Mueller S., Kuper J., Geerlof A., Wilmanns M., Singh R.K., Tucker P.A., Weiss M.S.
Acta Crystallogr. D 63:366-380(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH CALCIUM AND MANGANESE IONS.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRA59417.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A7AX-ray1.75A1-237[»]
2G4IX-ray2.40A1-237[»]
3QLQX-ray1.70A/B/C/D1-237[»]
ProteinModelPortalP81461.
SMRP81461. Positions 1-237.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP81461.

Entry information

Entry nameCONA_CANCT
AccessionPrimary (citable) accession number: P81461
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references