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P81461

- CONA_CANCT

UniProt

P81461 - CONA_CANCT

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Protein
Concanavalin-A
Gene
N/A
Organism
Canavalia cathartica (Jackbean) (Canavalia virosa)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Glucose/D-mannose specific lectin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Manganese
Metal bindingi10 – 101Calcium
Metal bindingi10 – 101Manganese
Metal bindingi12 – 121Calcium; via carbonyl oxygen
Binding sitei12 – 121Carbohydrate By similarity
Metal bindingi14 – 141Calcium
Metal bindingi19 – 191Calcium
Metal bindingi19 – 191Manganese
Metal bindingi24 – 241Manganese
Metal bindingi208 – 2081Calcium By similarity
Binding sitei228 – 2281Carbohydrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. mannose binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Manganese, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Concanavalin-A
Short name:
Con A
OrganismiCanavalia cathartica (Jackbean) (Canavalia virosa)
Taxonomic identifieri28958 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Concanavalin-A
PRO_0000105088Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107
Helixi15 – 173
Beta strandi24 – 3310
Beta strandi35 – 395
Beta strandi46 – 5510
Turni56 – 594
Beta strandi60 – 667
Beta strandi73 – 786
Helixi81 – 833
Beta strandi87 – 9610
Beta strandi98 – 1003
Beta strandi105 – 11814
Beta strandi123 – 13210
Beta strandi140 – 1445
Helixi150 – 1523
Beta strandi153 – 1575
Beta strandi170 – 1778
Beta strandi186 – 19813
Beta strandi202 – 2054
Beta strandi209 – 2157
Helixi227 – 2293
Turni230 – 2323

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A7AX-ray1.75A1-237[»]
2G4IX-ray2.40A1-237[»]
3QLQX-ray1.70A/B/C/D1-237[»]
ProteinModelPortaliP81461.
SMRiP81461. Positions 1-237.

Miscellaneous databases

EvolutionaryTraceiP81461.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 1002Carbohydrate binding By similarity

Sequence similaritiesi

Belongs to the leguminous lectin family.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81461-1 [UniParc]FASTAAdd to Basket

« Hide

ADTIVAVELD TYPNTDIGDP SYPHIGIDIK SVRSKKTAKW NMQNGKVGTA    50
HIIYNSVGKR LSAVVSYPNG DSATVSYDVD LDNVLPEWVR VGLSASTGLY 100
KETNTILSWS FTSKLKSNST HETNALHFMF NQFSKDQKDL ILQGDATTGT 150
DGNLELTRVS SNGSPQGNSV GRALFYAPVH IWESSAVVAS FDATFTFLIK 200
SPDSHPADGI AFFISNIDSS IPSGSTGRLL GLFPDAN 237
Length:237
Mass (Da):25,539
Last modified:December 15, 1998 - v1
Checksum:iDD31D2BFCC6EDD07
GO

Sequence databases

PIRiA59417.

Cross-referencesi

Sequence databases

PIRi A59417.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A7A X-ray 1.75 A 1-237 [» ]
2G4I X-ray 2.40 A 1-237 [» ]
3QLQ X-ray 1.70 A/B/C/D 1-237 [» ]
ProteinModelPortali P81461.
SMRi P81461. Positions 1-237.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P81461.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view ]
Pfami PF00139. Lectin_legB. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structures of concanavalin A-like lectins from seeds of two species of Canavalia."
    Fujimura S., Terada S., Jayavardhanan K.K., Panikkar K.R., Kimoto E.
    Phytochemistry 33:985-987(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. "On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths."
    Mueller-Dieckmann C., Panjikar S., Schmidt A., Mueller S., Kuper J., Geerlof A., Wilmanns M., Singh R.K., Tucker P.A., Weiss M.S.
    Acta Crystallogr. D 63:366-380(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH CALCIUM AND MANGANESE IONS.

Entry informationi

Entry nameiCONA_CANCT
AccessioniPrimary (citable) accession number: P81461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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