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P81460 (CONA_CANLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Concanavalin-A

Short name=Con A
OrganismCanavalia lineata (Beach bean) (Dolichos lineatus)
Taxonomic identifier28957 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glucose/D-mannose specific lectin.

Subunit structure

Homotetramer.

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Sequence similarities

Belongs to the leguminous lectin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Concanavalin-A
PRO_0000105087

Regions

Region99 – 1002Carbohydrate binding By similarity

Sites

Metal binding81Manganese By similarity
Metal binding101Calcium By similarity
Metal binding101Manganese By similarity
Metal binding121Calcium; via carbonyl oxygen By similarity
Metal binding141Calcium By similarity
Metal binding191Calcium By similarity
Metal binding191Manganese By similarity
Metal binding241Manganese By similarity
Metal binding2081Calcium By similarity
Binding site121Carbohydrate By similarity
Binding site2281Carbohydrate; via amide nitrogen By similarity

Secondary structure

............................................ 237
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P81460 [UniParc].

Last modified December 15, 1998. Version 1.
Checksum: 2D31C2BD3D30D66A

FASTA23725,497
        10         20         30         40         50         60 
ADTIVAVELD TYPNTDIGDP SYPHIGIDIK SVRSKKTAKW NMQNGKVGTA HIIYNSVGKR 

        70         80         90        100        110        120 
LSAVVSYPNG DSATVSYDVD LDNVLPEWVR VGLSASTGLY KETNTILSWS FTSKLKSNST 

       130        140        150        160        170        180 
HETNALHFVF NQFSKDQKDL ILQGDATTGT DGNLELTRVS SNGSPQGNSV GRALFYAPVH 

       190        200        210        220        230 
IWESSAVVAS FDATFTFLIK SSDSHPADGI AFFISNIDSS IPSGSTGRLL GLFPDAN 

« Hide

References

[1]"Primary structures of concanavalin A-like lectins from seeds of two species of Canavalia."
Fujimura S., Terada S., Jayavardhanan K.K., Panikkar K.R., Kimoto E.
Phytochemistry 33:985-987(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRA59415.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CWMX-ray1.95A1-237[»]
2CY6X-ray2.00A/D1-237[»]
2CYFX-ray1.80A1-237[»]
3SNMX-ray2.15A1-237[»]
4DPNX-ray2.55A/D1-237[»]
4I30X-ray1.89A1-237[»]
ProteinModelPortalP81460.
SMRP81460. Positions 1-237.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP81460.

Entry information

Entry nameCONA_CANLI
AccessionPrimary (citable) accession number: P81460
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references