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P81435

- SERC_BUCAP

UniProt

P81435 - SERC_BUCAP

Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotation

    Catalytic activityi

    O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation
    4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421L-glutamateUniRule annotation
    Binding sitei102 – 1021Pyridoxal phosphateUniRule annotation
    Binding sitei153 – 1531Pyridoxal phosphateUniRule annotation
    Binding sitei173 – 1731Pyridoxal phosphateUniRule annotation
    Binding sitei196 – 1961Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-serine biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Pyridoxine biosynthesis, Serine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-316-MONOMER.
    UniPathwayiUPA00135; UER00197.
    UPA00244; UER00311.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
    Alternative name(s):
    Phosphohydroxythreonine aminotransferaseUniRule annotation
    Short name:
    PSATUniRule annotation
    Gene namesi
    Name:serCUniRule annotation
    Ordered Locus Names:BUsg_302
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Phosphoserine aminotransferasePRO_0000150159Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei197 – 1971N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg302.

    Structurei

    3D structure databases

    ProteinModelPortaliP81435.
    SMRiP81435. Positions 4-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 772Pyridoxal phosphate bindingUniRule annotation
    Regioni238 – 2392Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1932.
    KOiK00831.
    OMAiFAAIPMN.
    OrthoDBiEOG60CWP3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00160. SerC_aminotrans_5.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR003248. Pser_aminoTfrase_subgr.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000525. SerC. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01364. serC_1. 1 hit.
    PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P81435-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLIYNFSAG PAMIPKDVLY QAKKELQNWN QIGCSIMEIS HRSKEFIQVA    50
    LEAEQDLRDL LNISNSYEIL FCQGGARGQF AAVPMNLLGN FKETDYINSG 100
    YWSNCALIEA KKYCIPKNIS VRQKKNGKSF LLKPSQWNIS DNSAYIHYCP 150
    NETIDGMSIY EEPNFKNKII VGDFSSFILS RRINIENYGL IYAGAQKNIG 200
    PSGITIILIR KDLIGYASKI SPSIFNYYII SKYNSMFNTP PTFSWYLSGL 250
    VFKWLKKQGG IKKIEQLNQK KSNLLYQIID NSNFYINDID KRNRSQMNVV 300
    FHLYNSKLDN LFLKEAKNAG LNALKGHNVI GGMRASIYNA MPLEGVQSLA 350
    KFMLYFEKKY G 361
    Length:361
    Mass (Da):41,261
    Last modified:August 1, 1998 - v1
    Checksum:iF30153652525047D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43549 Genomic DNA. Translation: AAC05435.1.
    AE013218 Genomic DNA. Translation: AAM67856.1.
    RefSeqiNP_660645.1. NC_004061.1.
    WP_011053823.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67856; AAM67856; BUsg_302.
    GeneIDi1005506.
    KEGGibas:BUsg302.
    PATRICi21247411. VBIBucAph100086_0315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43549 Genomic DNA. Translation: AAC05435.1 .
    AE013218 Genomic DNA. Translation: AAM67856.1 .
    RefSeqi NP_660645.1. NC_004061.1.
    WP_011053823.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali P81435.
    SMRi P81435. Positions 4-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67856 ; AAM67856 ; BUsg_302 .
    GeneIDi 1005506.
    KEGGi bas:BUsg302.
    PATRICi 21247411. VBIBucAph100086_0315.

    Phylogenomic databases

    eggNOGi COG1932.
    KOi K00831.
    OMAi FAAIPMN.
    OrthoDBi EOG60CWP3.

    Enzyme and pathway databases

    UniPathwayi UPA00135 ; UER00197 .
    UPA00244 ; UER00311 .
    BioCyci BAPH198804:GHMG-316-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00160. SerC_aminotrans_5.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR003248. Pser_aminoTfrase_subgr.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000525. SerC. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01364. serC_1. 1 hit.
    PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a DNA fragment from Buchnera aphidicola (Aphid endosymbiont) containing the genes aspS-trxB-serS-serC-aroA-rpsA-himD-tpiA."
      Thao M.L., Baumann P.
      Curr. Microbiol. 35:68-69(1997)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiSERC_BUCAP
    AccessioniPrimary (citable) accession number: P81435
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3