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P81435

- SERC_BUCAP

UniProt

P81435 - SERC_BUCAP

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Protein

Phosphoserine aminotransferase

Gene
serC, BUsg_302
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity.UniRule annotation

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421L-glutamate By similarity
Binding sitei102 – 1021Pyridoxal phosphate By similarity
Binding sitei153 – 1531Pyridoxal phosphate By similarity
Binding sitei173 – 1731Pyridoxal phosphate By similarity
Binding sitei196 – 1961Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-serine biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Pyridoxine biosynthesis, Serine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-316-MONOMER.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferase (EC:2.6.1.52)
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Short name:
PSAT
Gene namesi
Name:serC
Ordered Locus Names:BUsg_302
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Phosphoserine aminotransferaseUniRule annotationPRO_0000150159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg302.

Structurei

3D structure databases

ProteinModelPortaliP81435.
SMRiP81435. Positions 4-361.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 772Pyridoxal phosphate binding By similarity
Regioni238 – 2392Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1932.
KOiK00831.
OMAiFAAIPMN.
OrthoDBiEOG60CWP3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81435-1 [UniParc]FASTAAdd to Basket

« Hide

MNLIYNFSAG PAMIPKDVLY QAKKELQNWN QIGCSIMEIS HRSKEFIQVA    50
LEAEQDLRDL LNISNSYEIL FCQGGARGQF AAVPMNLLGN FKETDYINSG 100
YWSNCALIEA KKYCIPKNIS VRQKKNGKSF LLKPSQWNIS DNSAYIHYCP 150
NETIDGMSIY EEPNFKNKII VGDFSSFILS RRINIENYGL IYAGAQKNIG 200
PSGITIILIR KDLIGYASKI SPSIFNYYII SKYNSMFNTP PTFSWYLSGL 250
VFKWLKKQGG IKKIEQLNQK KSNLLYQIID NSNFYINDID KRNRSQMNVV 300
FHLYNSKLDN LFLKEAKNAG LNALKGHNVI GGMRASIYNA MPLEGVQSLA 350
KFMLYFEKKY G 361
Length:361
Mass (Da):41,261
Last modified:August 1, 1998 - v1
Checksum:iF30153652525047D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43549 Genomic DNA. Translation: AAC05435.1.
AE013218 Genomic DNA. Translation: AAM67856.1.
RefSeqiNP_660645.1. NC_004061.1.
WP_011053823.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67856; AAM67856; BUsg_302.
GeneIDi1005506.
KEGGibas:BUsg302.
PATRICi21247411. VBIBucAph100086_0315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43549 Genomic DNA. Translation: AAC05435.1 .
AE013218 Genomic DNA. Translation: AAM67856.1 .
RefSeqi NP_660645.1. NC_004061.1.
WP_011053823.1. NC_004061.1.

3D structure databases

ProteinModelPortali P81435.
SMRi P81435. Positions 4-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg302.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67856 ; AAM67856 ; BUsg_302 .
GeneIDi 1005506.
KEGGi bas:BUsg302.
PATRICi 21247411. VBIBucAph100086_0315.

Phylogenomic databases

eggNOGi COG1932.
KOi K00831.
OMAi FAAIPMN.
OrthoDBi EOG60CWP3.

Enzyme and pathway databases

UniPathwayi UPA00135 ; UER00197 .
UPA00244 ; UER00311 .
BioCyci BAPH198804:GHMG-316-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00160. SerC_aminotrans_5.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF000525. SerC. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01364. serC_1. 1 hit.
PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a DNA fragment from Buchnera aphidicola (Aphid endosymbiont) containing the genes aspS-trxB-serS-serC-aroA-rpsA-himD-tpiA."
    Thao M.L., Baumann P.
    Curr. Microbiol. 35:68-69(1997)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSERC_BUCAP
AccessioniPrimary (citable) accession number: P81435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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