Reviewed, UniProtKB/Swiss-Prot P81417 (CECA1_AEDAL)

Names and origin

Protein names

Recommended name:
    Cecropin-A1
Alternative name(s):
    Cecropin-A
    AalCecA

Gene names

Name:	CECA1
Synonyms:	CECA

Organism

Aedes albopictus (Asian tiger mosquito) (Culex albopictus)

Taxonomic identifier

7160 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Aedes › Stegomyia

Protein attributes

Sequence length	59 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Subcellular location	Secreted.
Sequence similarities	Belongs to the cecropin family.

Ontologies

Keywords
Biological process	Immune response Innate immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.3
	Chain	24 – 58	35	Cecropin-A1		PRO_0000004812

Sequences

	Sequence		Length	Mass (Da)
	P81417-1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: 84BC07E43D8AECC2	FASTA	59	6,136
	10 20 30 40 50 MNFTKLFAIV LLAALVLLGQ TEAGGLKKLG KKLEGVGKRV FKASEKALPV AVGIKALGK

References

[1]	"Cloning and expression of three cecropin cDNAs from a mosquito cell line." Sun D., Eccleston E.D., Fallon A.M. FEBS Lett. 454:147-151(1999) [PubMed: 10413113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of genomic DNA encoding mosquito cecropins." Sun D., Fallon A.M. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Peptide sequence of an antibiotic cecropin from the vector mosquito, Aedes albopictus." Sun D., Eccleston E.D., Fallon A.M. Biochem. Biophys. Res. Commun. 249:410-415(1998) [PubMed: 9712710] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF145802 mRNA. Translation: AAD37701.1. AF394744 Genomic DNA. Translation: AAK81849.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000875. Cecropin. [Graphical view]
Pfam	PF00272. Cecropin. 1 hit. [Graphical view]
PROSITE	PS00268. CECROPIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CECA1_AEDAL

Accession

Primary (citable) accession number: P81417
Secondary accession number(s): Q963B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	April 13, 2004
Last modified:	June 16, 2009
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)