P81408 (F189B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM189B

Alternative name(s):
Protein COTE1

Gene names

Name:	FAM189B
Synonyms:	C1orf2, COTE1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	May interact with WWOX.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the FAM189 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
WWOX	Q9NZC7	2	EBI-6366314,EBI-4320739

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P81408-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P81408-2)

The sequence of this isoform differs from the canonical sequence as follows:
     76-171: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	Protein FAM189B		PRO_0000079261
Regions
	Transmembrane	34 – 54	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Compositional bias	243 – 249	7	Poly-Pro
	Compositional bias	634 – 638	5	Poly-Ser
Amino acid modifications
	Glycosylation	160	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	76 – 171	96	Missing in isoform B.		VSP_038926
	Natural variant	358	1	S → F in a breast cancer sample; somatic mutation. Ref.7		VAR_035684
	Natural variant	549	1	R → H. Corresponds to variant rs2072648 [ dbSNP | Ensembl ].		VAR_037876
	Natural variant	646	1	R → H. Corresponds to variant rs2072648 [ dbSNP | Ensembl ].		VAR_056842
Experimental info
	Sequence conflict	207	1	T → TQ in AAC51822. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified April 20, 2010. Version 2. Checksum: E22EED90923826BD	FASTA	668	71,355
	10 20 30 40 50 60 MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT FSMVASSVTT 70 80 90 100 110 120 TESIKRSCPS WAGFSLAFSG VVGIVSWKRP FTLVISFFSL LSVLCVMLSM AGSVLSCKNA 130 140 150 160 170 180 QLARDFQQCS LEGKVCVCCP SVPLLRPCPE SGQELKVAPN STCDEARGAL KNLLFSVCGL 190 200 210 220 230 240 TICAAIICTL SAIVCCIQIF SLDLVHTLAP ERSVSGPLGP LGCTSPPPAP LLHTMLDLEE 250 260 270 280 290 300 FVPPVPPPPY YPPEYTCSSE TDAQSITYNG SMDSPVPLYP TDCPPSYEAV MGLRGDSQAT 310 320 330 340 350 360 LFDPQLHDGS CICERVASIV DVSMDSGSLV LSAIGDLPGG SSPSEDSCLL ELQGSVRSVD 370 380 390 400 410 420 YVLFRSIQRS RAGYCLSLDC GLRGPFEESP LPRRPPRAAR SYSCSAPEAP PPLGAPTAAR 430 440 450 460 470 480 SCHRLEGWPP WVGPCFPELR RRVPRGGGRP AAAPPTRAPT RRFSDSSGSL TPPGHRPPHP 490 500 510 520 530 540 ASPPPLLLPR SHSDPGITTS SDTADFRDLY TKVLEEEAAS VSSADTGLCS EACLFRLARC 550 560 570 580 590 600 PSPKLLRARS AEKRRPVPTF QKVPLPSGPA PAHSLGDLKG SWPGRGLVTR FLQISRKAPD 610 620 630 640 650 660 PSGTGAHGHK QVPRSLWGRP GRESLHLRSC GDLSSSSSLR RLLSGRRLER GTRPHSLSLN GGSRETGL
	Isoform B [UniParc]. Checksum: 103AAACFCBD20DF3	FASTA	572	61,135
	10 20 30 40 50 60 MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT FSMVASSVTT 70 80 90 100 110 120 TESIKRSCPS WAGFSNLLFS VCGLTICAAI ICTLSAIVCC IQIFSLDLVH TLAPERSVSG 130 140 150 160 170 180 PLGPLGCTSP PPAPLLHTML DLEEFVPPVP PPPYYPPEYT CSSETDAQSI TYNGSMDSPV 190 200 210 220 230 240 PLYPTDCPPS YEAVMGLRGD SQATLFDPQL HDGSCICERV ASIVDVSMDS GSLVLSAIGD 250 260 270 280 290 300 LPGGSSPSED SCLLELQGSV RSVDYVLFRS IQRSRAGYCL SLDCGLRGPF EESPLPRRPP 310 320 330 340 350 360 RAARSYSCSA PEAPPPLGAP TAARSCHRLE GWPPWVGPCF PELRRRVPRG GGRPAAAPPT 370 380 390 400 410 420 RAPTRRFSDS SGSLTPPGHR PPHPASPPPL LLPRSHSDPG ITTSSDTADF RDLYTKVLEE 430 440 450 460 470 480 EAASVSSADT GLCSEACLFR LARCPSPKLL RARSAEKRRP VPTFQKVPLP SGPAPAHSLG 490 500 510 520 530 540 DLKGSWPGRG LVTRFLQISR KAPDPSGTGA HGHKQVPRSL WGRPGRESLH LRSCGDLSSS 550 560 570 SSLRRLLSGR RLERGTRPHS LSLNGGSRET GL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease." Winfield S.L., Tayebi N., Martin B.M., Ginns E.I., Sidransky E. Genome Res. 7:1020-1026(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Hippocampus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B). Tissue: Brain, Lymph and Pancreas.
[5]	"WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins." Ludes-Meyers J.H., Kil H., Bednarek A.K., Drake J., Bedford M.T., Aldaz C.M. Oncogene 23:5049-5055(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WWOX.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-358.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF023268 Genomic DNA. Translation: AAC51822.1. AL713999 Genomic DNA. Translation: CAI95092.1. AL713999 Genomic DNA. Translation: CAI95094.1. CH471121 Genomic DNA. Translation: EAW53094.1. CH471121 Genomic DNA. Translation: EAW53097.1. BC040136 mRNA. Translation: AAH40136.2. BC006493 mRNA. Translation: AAH06493.1. BC007444 mRNA. Translation: AAH07444.1. BC010471 mRNA. Translation: AAH10471.1.
IPI	IPI00386600. IPI00514706.
PIR	T08827.
RefSeq	NP_006580.2. NM_006589.2. NP_937995.1. NM_198264.1.
UniGene	Hs.348308.
3D structure databases
ProteinModelPortal	P81408.
ModBase	Search...
Protein-protein interaction databases
IntAct	P81408. 1 interaction.
STRING	9606.ENSP00000354958.
PTM databases
PhosphoSite	P81408.
Polymorphism databases
DMDM	294862432.
Proteomic databases
PaxDb	P81408.
PRIDE	P81408.
Protocols and materials databases
DNASU	10712.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000350210; ENSP00000307128; ENSG00000160767. ENST00000361361; ENSP00000354958; ENSG00000160767. ENST00000574749; ENSP00000460960; ENSG00000262666. ENST00000575430; ENSP00000461152; ENSG00000262666.
GeneID	10712.
KEGG	hsa:10712.
UCSC	uc001fjm.3. human. uc001fjn.3. human.
Organism-specific databases
CTD	10712.
GeneCards	GC01M155216.
H-InvDB	HIX0199898.
HGNC	HGNC:1233. FAM189B.
HPA	HPA006659.
neXtProt	NX_P81408.
PharmGKB	PA25608.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26718.
HOGENOM	HOG000049214.
HOVERGEN	HBG051081.
InParanoid	P81408.
OMA	KVCVCCP.
PhylomeDB	P81408.
Gene expression databases
ArrayExpress	P81408.
Bgee	P81408.
CleanEx	HS_C1orf2.
Genevestigator	P81408.
GermOnline	ENSG00000160767. Homo sapiens.
Family and domain databases
InterPro	IPR007237. CD20-like. [Graphical view]
Pfam	PF04103. CD20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAM189B. human.
GenomeRNAi	10712.
NextBio	40665.

Entry information

Entry name

F189B_HUMAN

Accession

Primary (citable) accession number: P81408
Secondary accession number(s): Q8IXL3, Q9BR66

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.