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P81408

- F189B_HUMAN

UniProt

P81408 - F189B_HUMAN

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Protein

Protein FAM189B

Gene

FAM189B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. WW domain binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM189B
Alternative name(s):
Protein COTE1
Gene namesi
Name:FAM189B
Synonyms:C1orf2, COTE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1233. FAM189B.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Protein FAM189BPRO_0000079261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP81408.
PaxDbiP81408.
PRIDEiP81408.

PTM databases

PhosphoSiteiP81408.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiP81408.
CleanExiHS_C1orf2.
ExpressionAtlasiP81408. baseline and differential.
GenevestigatoriP81408.

Organism-specific databases

HPAiHPA006659.

Interactioni

Subunit structurei

May interact with WWOX.

Binary interactionsi

WithEntry#Exp.IntActNotes
WWOXQ9NZC72EBI-6366314,EBI-4320739

Protein-protein interaction databases

BioGridi115938. 35 interactions.
IntActiP81408. 1 interaction.
STRINGi9606.ENSP00000354958.

Structurei

3D structure databases

ProteinModelPortaliP81408.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi243 – 2497Poly-Pro
Compositional biasi634 – 6385Poly-Ser

Sequence similaritiesi

Belongs to the FAM189 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26718.
GeneTreeiENSGT00530000063335.
HOGENOMiHOG000049214.
HOVERGENiHBG051081.
InParanoidiP81408.
OMAiSWKRPFT.
OrthoDBiEOG7X0VGX.
PhylomeDBiP81408.
TreeFamiTF332736.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P81408-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT
60 70 80 90 100
FSMVASSVTT TESIKRSCPS WAGFSLAFSG VVGIVSWKRP FTLVISFFSL
110 120 130 140 150
LSVLCVMLSM AGSVLSCKNA QLARDFQQCS LEGKVCVCCP SVPLLRPCPE
160 170 180 190 200
SGQELKVAPN STCDEARGAL KNLLFSVCGL TICAAIICTL SAIVCCIQIF
210 220 230 240 250
SLDLVHTLAP ERSVSGPLGP LGCTSPPPAP LLHTMLDLEE FVPPVPPPPY
260 270 280 290 300
YPPEYTCSSE TDAQSITYNG SMDSPVPLYP TDCPPSYEAV MGLRGDSQAT
310 320 330 340 350
LFDPQLHDGS CICERVASIV DVSMDSGSLV LSAIGDLPGG SSPSEDSCLL
360 370 380 390 400
ELQGSVRSVD YVLFRSIQRS RAGYCLSLDC GLRGPFEESP LPRRPPRAAR
410 420 430 440 450
SYSCSAPEAP PPLGAPTAAR SCHRLEGWPP WVGPCFPELR RRVPRGGGRP
460 470 480 490 500
AAAPPTRAPT RRFSDSSGSL TPPGHRPPHP ASPPPLLLPR SHSDPGITTS
510 520 530 540 550
SDTADFRDLY TKVLEEEAAS VSSADTGLCS EACLFRLARC PSPKLLRARS
560 570 580 590 600
AEKRRPVPTF QKVPLPSGPA PAHSLGDLKG SWPGRGLVTR FLQISRKAPD
610 620 630 640 650
PSGTGAHGHK QVPRSLWGRP GRESLHLRSC GDLSSSSSLR RLLSGRRLER
660
GTRPHSLSLN GGSRETGL
Length:668
Mass (Da):71,355
Last modified:April 20, 2010 - v2
Checksum:iE22EED90923826BD
GO
Isoform B (identifier: P81408-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-171: Missing.

Show »
Length:572
Mass (Da):61,135
Checksum:i103AAACFCBD20DF3
GO
Isoform 2 (identifier: P81408-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-94: Missing.
     207-207: T → TQ

Show »
Length:650
Mass (Da):69,425
Checksum:iC852AD556C0848D0
GO
Isoform 3 (identifier: P81408-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: T → TQ

Show »
Length:669
Mass (Da):71,483
Checksum:iE30360AC9A4571E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti358 – 3581S → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_035684
Natural varianti549 – 5491R → H.
Corresponds to variant rs2072648 [ dbSNP | Ensembl ].
VAR_037876
Natural varianti646 – 6461R → H.
Corresponds to variant rs2072648 [ dbSNP | Ensembl ].
VAR_056842

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 17196Missing in isoform B. 1 PublicationVSP_038926Add
BLAST
Alternative sequencei76 – 9419Missing in isoform 2. 1 PublicationVSP_046728Add
BLAST
Alternative sequencei207 – 2071T → TQ in isoform 2 and isoform 3. 1 PublicationVSP_046729

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF023268 Genomic DNA. Translation: AAC51822.1.
AL713999 Genomic DNA. Translation: CAI95092.1.
AL713999 Genomic DNA. Translation: CAI95094.1.
CH471121 Genomic DNA. Translation: EAW53094.1.
CH471121 Genomic DNA. Translation: EAW53097.1.
CH471121 Genomic DNA. Translation: EAW53098.1.
BC040136 mRNA. Translation: AAH40136.2.
BC006493 mRNA. Translation: AAH06493.1.
BC007444 mRNA. Translation: AAH07444.1.
BC010471 mRNA. Translation: AAH10471.1.
BC033707 mRNA. No translation available.
CCDSiCCDS1103.1. [P81408-1]
CCDS1104.1. [P81408-2]
CCDS58035.1. [P81408-3]
PIRiT08827.
RefSeqiNP_001254537.1. NM_001267608.1. [P81408-3]
NP_006580.2. NM_006589.2. [P81408-1]
NP_937995.1. NM_198264.1. [P81408-2]
XP_005244902.1. XM_005244845.1. [P81408-4]
XP_005276795.1. XM_005276738.1. [P81408-4]
UniGeneiHs.348308.

Genome annotation databases

EnsembliENST00000350210; ENSP00000307128; ENSG00000160767. [P81408-2]
ENST00000361361; ENSP00000354958; ENSG00000160767. [P81408-1]
ENST00000368368; ENSP00000357352; ENSG00000160767. [P81408-3]
ENST00000572488; ENSP00000458501; ENSG00000262666. [P81408-3]
ENST00000574749; ENSP00000460960; ENSG00000262666. [P81408-2]
ENST00000575430; ENSP00000461152; ENSG00000262666. [P81408-1]
GeneIDi10712.
KEGGihsa:10712.
UCSCiuc001fjm.3. human. [P81408-1]
uc001fjn.3. human. [P81408-2]
uc001fjo.3. human.

Polymorphism databases

DMDMi294862432.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF023268 Genomic DNA. Translation: AAC51822.1 .
AL713999 Genomic DNA. Translation: CAI95092.1 .
AL713999 Genomic DNA. Translation: CAI95094.1 .
CH471121 Genomic DNA. Translation: EAW53094.1 .
CH471121 Genomic DNA. Translation: EAW53097.1 .
CH471121 Genomic DNA. Translation: EAW53098.1 .
BC040136 mRNA. Translation: AAH40136.2 .
BC006493 mRNA. Translation: AAH06493.1 .
BC007444 mRNA. Translation: AAH07444.1 .
BC010471 mRNA. Translation: AAH10471.1 .
BC033707 mRNA. No translation available.
CCDSi CCDS1103.1. [P81408-1 ]
CCDS1104.1. [P81408-2 ]
CCDS58035.1. [P81408-3 ]
PIRi T08827.
RefSeqi NP_001254537.1. NM_001267608.1. [P81408-3 ]
NP_006580.2. NM_006589.2. [P81408-1 ]
NP_937995.1. NM_198264.1. [P81408-2 ]
XP_005244902.1. XM_005244845.1. [P81408-4 ]
XP_005276795.1. XM_005276738.1. [P81408-4 ]
UniGenei Hs.348308.

3D structure databases

ProteinModelPortali P81408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115938. 35 interactions.
IntActi P81408. 1 interaction.
STRINGi 9606.ENSP00000354958.

PTM databases

PhosphoSitei P81408.

Polymorphism databases

DMDMi 294862432.

Proteomic databases

MaxQBi P81408.
PaxDbi P81408.
PRIDEi P81408.

Protocols and materials databases

DNASUi 10712.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000350210 ; ENSP00000307128 ; ENSG00000160767 . [P81408-2 ]
ENST00000361361 ; ENSP00000354958 ; ENSG00000160767 . [P81408-1 ]
ENST00000368368 ; ENSP00000357352 ; ENSG00000160767 . [P81408-3 ]
ENST00000572488 ; ENSP00000458501 ; ENSG00000262666 . [P81408-3 ]
ENST00000574749 ; ENSP00000460960 ; ENSG00000262666 . [P81408-2 ]
ENST00000575430 ; ENSP00000461152 ; ENSG00000262666 . [P81408-1 ]
GeneIDi 10712.
KEGGi hsa:10712.
UCSCi uc001fjm.3. human. [P81408-1 ]
uc001fjn.3. human. [P81408-2 ]
uc001fjo.3. human.

Organism-specific databases

CTDi 10712.
GeneCardsi GC01M155216.
H-InvDB HIX0199898.
HGNCi HGNC:1233. FAM189B.
HPAi HPA006659.
neXtProti NX_P81408.
PharmGKBi PA25608.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26718.
GeneTreei ENSGT00530000063335.
HOGENOMi HOG000049214.
HOVERGENi HBG051081.
InParanoidi P81408.
OMAi SWKRPFT.
OrthoDBi EOG7X0VGX.
PhylomeDBi P81408.
TreeFami TF332736.

Miscellaneous databases

ChiTaRSi FAM189B. human.
GenomeRNAii 10712.
NextBioi 40665.
PROi P81408.

Gene expression databases

Bgeei P81408.
CleanExi HS_C1orf2.
ExpressionAtlasi P81408. baseline and differential.
Genevestigatori P81408.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease."
    Winfield S.L., Tayebi N., Martin B.M., Ginns E.I., Sidransky E.
    Genome Res. 7:1020-1026(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
    Tissue: Hippocampus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A; B AND 2).
    Tissue: Brain, Lymph and Pancreas.
  5. "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins."
    Ludes-Meyers J.H., Kil H., Bednarek A.K., Drake J., Bedford M.T., Aldaz C.M.
    Oncogene 23:5049-5055(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWOX.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-358.

Entry informationi

Entry nameiF189B_HUMAN
AccessioniPrimary (citable) accession number: P81408
Secondary accession number(s): B1AVS5, Q8IXL3, Q9BR66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3