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Protein

Protein FAM189B

Gene

FAM189B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM189B
Alternative name(s):
Protein COTE1
Gene namesi
Name:FAM189B
Synonyms:C1orf2, COTE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160767.20.
HGNCiHGNC:1233. FAM189B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10712.
OpenTargetsiENSG00000160767.
PharmGKBiPA25608.

Polymorphism and mutation databases

BioMutaiFAM189B.
DMDMi294862432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792611 – 668Protein FAM189BAdd BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei358PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP81408.
PaxDbiP81408.
PeptideAtlasiP81408.
PRIDEiP81408.

PTM databases

iPTMnetiP81408.
PhosphoSitePlusiP81408.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000160767.
CleanExiHS_C1orf2.
ExpressionAtlasiP81408. baseline and differential.
GenevisibleiP81408. HS.

Organism-specific databases

HPAiHPA006659.
HPA050674.

Interactioni

Subunit structurei

May interact with WWOX.

Binary interactionsi

WithEntry#Exp.IntActNotes
WWOXQ9NZC72EBI-6366314,EBI-4320739

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115938. 104 interactors.
IntActiP81408. 2 interactors.
STRINGi9606.ENSP00000354958.

Structurei

3D structure databases

ProteinModelPortaliP81408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 249Poly-Pro7
Compositional biasi634 – 638Poly-Ser5

Sequence similaritiesi

Belongs to the FAM189 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IET7. Eukaryota.
ENOG410YD59. LUCA.
GeneTreeiENSGT00530000063335.
HOGENOMiHOG000049214.
HOVERGENiHBG051081.
InParanoidiP81408.
OMAiSWKRPFT.
OrthoDBiEOG091G06KS.
PhylomeDBiP81408.
TreeFamiTF332736.

Family and domain databases

InterProiView protein in InterPro
IPR007237. CD20-like.
IPR030431. FAM189.
PANTHERiPTHR17615. PTHR17615. 1 hit.
PfamiView protein in Pfam
PF04103. CD20. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P81408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT
60 70 80 90 100
FSMVASSVTT TESIKRSCPS WAGFSLAFSG VVGIVSWKRP FTLVISFFSL
110 120 130 140 150
LSVLCVMLSM AGSVLSCKNA QLARDFQQCS LEGKVCVCCP SVPLLRPCPE
160 170 180 190 200
SGQELKVAPN STCDEARGAL KNLLFSVCGL TICAAIICTL SAIVCCIQIF
210 220 230 240 250
SLDLVHTLAP ERSVSGPLGP LGCTSPPPAP LLHTMLDLEE FVPPVPPPPY
260 270 280 290 300
YPPEYTCSSE TDAQSITYNG SMDSPVPLYP TDCPPSYEAV MGLRGDSQAT
310 320 330 340 350
LFDPQLHDGS CICERVASIV DVSMDSGSLV LSAIGDLPGG SSPSEDSCLL
360 370 380 390 400
ELQGSVRSVD YVLFRSIQRS RAGYCLSLDC GLRGPFEESP LPRRPPRAAR
410 420 430 440 450
SYSCSAPEAP PPLGAPTAAR SCHRLEGWPP WVGPCFPELR RRVPRGGGRP
460 470 480 490 500
AAAPPTRAPT RRFSDSSGSL TPPGHRPPHP ASPPPLLLPR SHSDPGITTS
510 520 530 540 550
SDTADFRDLY TKVLEEEAAS VSSADTGLCS EACLFRLARC PSPKLLRARS
560 570 580 590 600
AEKRRPVPTF QKVPLPSGPA PAHSLGDLKG SWPGRGLVTR FLQISRKAPD
610 620 630 640 650
PSGTGAHGHK QVPRSLWGRP GRESLHLRSC GDLSSSSSLR RLLSGRRLER
660
GTRPHSLSLN GGSRETGL
Length:668
Mass (Da):71,355
Last modified:April 20, 2010 - v2
Checksum:iE22EED90923826BD
GO
Isoform B (identifier: P81408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-171: Missing.

Show »
Length:572
Mass (Da):61,135
Checksum:i103AAACFCBD20DF3
GO
Isoform 2 (identifier: P81408-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-94: Missing.
     207-207: T → TQ

Show »
Length:650
Mass (Da):69,425
Checksum:iC852AD556C0848D0
GO
Isoform 3 (identifier: P81408-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: T → TQ

Show »
Length:669
Mass (Da):71,483
Checksum:iE30360AC9A4571E6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035684358S → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_037876549R → H. Corresponds to variant dbSNP:rs2072648Ensembl.1
Natural variantiVAR_056842646R → H. Corresponds to variant dbSNP:rs2072648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03892676 – 171Missing in isoform B. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_04672876 – 94Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_046729207T → TQ in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023268 Genomic DNA. Translation: AAC51822.1.
AL713999 Genomic DNA. Translation: CAI95092.1.
AL713999 Genomic DNA. Translation: CAI95094.1.
CH471121 Genomic DNA. Translation: EAW53094.1.
CH471121 Genomic DNA. Translation: EAW53097.1.
CH471121 Genomic DNA. Translation: EAW53098.1.
BC040136 mRNA. Translation: AAH40136.2.
BC006493 mRNA. Translation: AAH06493.1.
BC007444 mRNA. Translation: AAH07444.1.
BC010471 mRNA. Translation: AAH10471.1.
BC033707 mRNA. No translation available.
CCDSiCCDS1103.1. [P81408-1]
CCDS1104.1. [P81408-2]
CCDS58035.1. [P81408-3]
PIRiT08827.
RefSeqiNP_001254537.1. NM_001267608.1. [P81408-3]
NP_006580.2. NM_006589.2. [P81408-1]
NP_937995.1. NM_198264.1. [P81408-2]
XP_005244902.1. XM_005244845.1. [P81408-4]
UniGeneiHs.348308.

Genome annotation databases

EnsembliENST00000350210; ENSP00000307128; ENSG00000160767. [P81408-2]
ENST00000361361; ENSP00000354958; ENSG00000160767. [P81408-1]
ENST00000368368; ENSP00000357352; ENSG00000160767. [P81408-3]
ENST00000572488; ENSP00000458501; ENSG00000262666. [P81408-3]
ENST00000574749; ENSP00000460960; ENSG00000262666. [P81408-2]
ENST00000575430; ENSP00000461152; ENSG00000262666. [P81408-1]
GeneIDi10712.
KEGGihsa:10712.
UCSCiuc001fjm.4. human. [P81408-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF189B_HUMAN
AccessioniPrimary (citable) accession number: P81408
Secondary accession number(s): B1AVS5, Q8IXL3, Q9BR66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 20, 2010
Last modified: September 27, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families