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Protein

Fatty acid-binding protein 2, liver

Gene
N/A
Organism
Ambystoma mexicanum (Axolotl)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). The specificity of axolotl L-FABP differs from that of LB-FABP. Binds 2 ligands per protein molecule.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Cholate 11 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein 2, liver
Alternative name(s):
Liver basic FABP
Short name:
LB-FABP
Liver-type fatty acid-binding protein
Short name:
L-FABP
OrganismiAmbystoma mexicanum (Axolotl)
Taxonomic identifieri8296 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673442 – 126Fatty acid-binding protein 2, liverAdd BLAST125

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Helixi15 – 22Combined sources8
Helixi26 – 32Combined sources7
Beta strandi38 – 53Combined sources16
Beta strandi58 – 64Combined sources7
Beta strandi69 – 72Combined sources4
Helixi74 – 76Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi84 – 86Combined sources3
Beta strandi89 – 93Combined sources5
Beta strandi95 – 104Combined sources10
Beta strandi107 – 114Combined sources8
Beta strandi117 – 125Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FT9X-ray2.50A2-126[»]
2FTBX-ray2.00A2-126[»]
ProteinModelPortaliP81400.
SMRiP81400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81400.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 56Cholate 1 binding3
Regioni99 – 101Cholate 2 binding3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005633.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR031276. Lb-FABP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF67. PTHR11955:SF67. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFNGTWQVY SQENYEAFLR AVGLPEDIIN VAKDINPIIE IQQNGDNFVV
60 70 80 90 100
TSKTPNQSVT NSFTIGKEAE ITSMGGKKIK CTVVLEGGKL VSKTDQFSHI
110 120
QEVKGNEMVE TLTVGGATLI RRSKRV
Length:126
Mass (Da):13,875
Last modified:January 23, 2007 - v2
Checksum:i130A84C12D0EB1AF
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FT9X-ray2.50A2-126[»]
2FTBX-ray2.00A2-126[»]
ProteinModelPortaliP81400.
SMRiP81400.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005633.

Miscellaneous databases

EvolutionaryTraceiP81400.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR031276. Lb-FABP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF67. PTHR11955:SF67. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP2_AMBME
AccessioniPrimary (citable) accession number: P81400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.