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Protein

Thaumatin-like protein

Gene

tlp

Organism
Actinidia deliciosa (Kiwi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antifungal activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Fungicide, Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Thaumatin-like protein
Alternative name(s):
Allergen: Act d 2
Gene namesi
Name:tlp
OrganismiActinidia deliciosa (Kiwi)
Taxonomic identifieri3627 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridsEricalesActinidiaceaeActinidia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds IgE.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3053. Act d 2.0101.
747. Act d 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 244 PublicationsAdd BLAST24
ChainiPRO_000009622325 – 225Thaumatin-like proteinAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 224PROSITE-ProRule annotation
Disulfide bondi74 ↔ 84PROSITE-ProRule annotation
Disulfide bondi89 ↔ 95PROSITE-ProRule annotation
Disulfide bondi140 ↔ 213PROSITE-ProRule annotation
Disulfide bondi146 ↔ 196PROSITE-ProRule annotation
Disulfide bondi154 ↔ 164PROSITE-ProRule annotation
Disulfide bondi168 ↔ 177PROSITE-ProRule annotation
Disulfide bondi178 ↔ 183PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP81370.

Expressioni

Tissue specificityi

Woody stem plug.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALTA1P790853EBI-9212168,EBI-9212161From a different organism.

Protein-protein interaction databases

IntActiP81370. 1 interactor.

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Beta strandi33 – 35Combined sources3
Beta strandi37 – 42Combined sources6
Beta strandi45 – 49Combined sources5
Beta strandi54 – 57Combined sources4
Beta strandi65 – 76Combined sources12
Beta strandi80 – 87Combined sources8
Beta strandi92 – 94Combined sources3
Beta strandi105 – 113Combined sources9
Beta strandi116 – 122Combined sources7
Beta strandi127 – 129Combined sources3
Beta strandi131 – 135Combined sources5
Beta strandi144 – 146Combined sources3
Helixi150 – 153Combined sources4
Helixi156 – 158Combined sources3
Helixi167 – 171Combined sources5
Helixi174 – 177Combined sources4
Helixi187 – 195Combined sources9
Beta strandi199 – 202Combined sources4
Helixi206 – 208Combined sources3
Beta strandi211 – 214Combined sources4
Beta strandi219 – 223Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BCTX-ray0.98A25-225[»]
ProteinModelPortaliP81370.
SMRiP81370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFKSLSLS ALLFIAFLFT CARGATFNII NNCPFTVWAA AVPGGGKRLD
60 70 80 90 100
RGQNWIINPG AGTKGARVWP RTGCNFDGAG RGKCQTGDCN GLLQCQAFGQ
110 120 130 140 150
PPNTLAEYAL NQFNNLDFFD ISLVDGFNVA MEFSPTSGGC TRGIKCTADI
160 170 180 190 200
NGQCPNELRA PGGCNNPCTV FKTDQYCCNS GNCGLTNFSK FFKDRCPDAY
210 220
SYPKDDQTST FTCPAGTNYK VVFCP
Length:225
Mass (Da):24,221
Last modified:June 10, 2008 - v2
Checksum:i229DABF722E7B961
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60G → S in ABQ42566 (Ref. 2) Curated1
Sequence conflicti176Y → F in ABQ42566 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871175 mRNA. Translation: CAI38795.2.
EF417825 Genomic DNA. Translation: ABQ42566.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ871175 mRNA. Translation: CAI38795.2.
EF417825 Genomic DNA. Translation: ABQ42566.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BCTX-ray0.98A25-225[»]
ProteinModelPortaliP81370.
SMRiP81370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP81370. 1 interactor.

Protein family/group databases

Allergomei3053. Act d 2.0101.
747. Act d 2.

Proteomic databases

PRIDEiP81370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLP_ACTDE
AccessioniPrimary (citable) accession number: P81370
Secondary accession number(s): A5JGY0, Q5ND92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.