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Protein

Concanavalin-Ma

Gene
N/A
Organism
Canavalia rosea (Beach bean) (Canavalia maritima)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Glucose/D-mannose specific lectin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81ManganeseBy similarity
Metal bindingi10 – 101CalciumBy similarity
Metal bindingi10 – 101ManganeseBy similarity
Metal bindingi12 – 121Calcium; via carbonyl oxygenBy similarity
Binding sitei12 – 121CarbohydrateBy similarity
Metal bindingi14 – 141CalciumBy similarity
Metal bindingi19 – 191CalciumBy similarity
Metal bindingi19 – 191ManganeseBy similarity
Metal bindingi24 – 241ManganeseBy similarity
Metal bindingi207 – 2071CalciumBy similarity
Binding sitei227 – 2271Carbohydrate; via amide nitrogenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Manganese, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Concanavalin-Ma
Short name:
Con Ma
OrganismiCanavalia rosea (Beach bean) (Canavalia maritima)
Taxonomic identifieri3825 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Concanavalin-MaPRO_0000105086Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
236
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107Combined sources
Helixi15 – 173Combined sources
Beta strandi24 – 3310Combined sources
Beta strandi35 – 384Combined sources
Beta strandi45 – 5410Combined sources
Turni55 – 584Combined sources
Beta strandi59 – 657Combined sources
Beta strandi71 – 777Combined sources
Helixi80 – 823Combined sources
Beta strandi86 – 9510Combined sources
Beta strandi97 – 993Combined sources
Beta strandi104 – 12017Combined sources
Beta strandi122 – 13110Combined sources
Beta strandi139 – 1435Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi153 – 1564Combined sources
Beta strandi169 – 1768Combined sources
Beta strandi185 – 19713Combined sources
Beta strandi201 – 2044Combined sources
Beta strandi208 – 2158Combined sources
Helixi226 – 2283Combined sources
Turni229 – 2313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CWMX-ray1.95A/D1-236[»]
2OW4X-ray1.60A1-236[»]
2P34X-ray2.10A/B/C/D1-236[»]
2P37X-ray2.10A/B/C/D1-236[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81364.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 992Carbohydrate bindingBy similarity

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ADTIVAVELD TYPNTDVGDP SYPHXXXXXX SVRXXTAKWN MQNGKVGTAH
60 70 80 90 100
ISYNSVGKRL SAVVSYPNGD SATVSYDVDL DNVLPEWVRV GLSASTGLYK
110 120 130 140 150
ETNTILSWSF TSKLKSNSTH ETNALHFMFN QFTKDQKDLI LQSDATTGTD
160 170 180 190 200
GNLXXTRVSS NGPSQGSTVG RALFYAPVHI WESSATVAGF DATFXXLIKS
210 220 230
PDSHPADGIA FFISNIDSSI PSGSTGRLLG LFPDAN
Length:236
Mass (Da):25,364
Last modified:December 15, 1998 - v1
Checksum:iD67791C3B0EB150A
GO

Sequence databases

PIRiB45587.

Cross-referencesi

Sequence databases

PIRiB45587.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CWMX-ray1.95A/D1-236[»]
2OW4X-ray1.60A1-236[»]
2P34X-ray2.10A/B/C/D1-236[»]
2P37X-ray2.10A/B/C/D1-236[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP81364.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCONA_CANRO
AccessioniPrimary (citable) accession number: P81364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.