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Protein

Concanavalin-Ma

Gene
N/A
Organism
Canavalia rosea (Beach bean) (Canavalia maritima)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Glucose/D-mannose specific lectin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8ManganeseBy similarity1
Metal bindingi10CalciumBy similarity1
Metal bindingi10ManganeseBy similarity1
Metal bindingi12Calcium; via carbonyl oxygenBy similarity1
Binding sitei12CarbohydrateBy similarity1
Metal bindingi14CalciumBy similarity1
Metal bindingi19CalciumBy similarity1
Metal bindingi19ManganeseBy similarity1
Metal bindingi24ManganeseBy similarity1
Metal bindingi207CalciumBy similarity1
Binding sitei227Carbohydrate; via amide nitrogenBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Manganese, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Concanavalin-Ma
Short name:
Con Ma
OrganismiCanavalia rosea (Beach bean) (Canavalia maritima)
Taxonomic identifieri3825 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeCanavalia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001050861 – 236Concanavalin-MaAdd BLAST236

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Helixi15 – 17Combined sources3
Beta strandi24 – 33Combined sources10
Beta strandi35 – 38Combined sources4
Beta strandi45 – 54Combined sources10
Turni55 – 58Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi71 – 77Combined sources7
Helixi80 – 82Combined sources3
Beta strandi86 – 95Combined sources10
Beta strandi97 – 99Combined sources3
Beta strandi104 – 120Combined sources17
Beta strandi122 – 131Combined sources10
Beta strandi139 – 143Combined sources5
Beta strandi149 – 151Combined sources3
Beta strandi153 – 156Combined sources4
Beta strandi169 – 176Combined sources8
Beta strandi185 – 197Combined sources13
Beta strandi201 – 204Combined sources4
Beta strandi208 – 215Combined sources8
Helixi226 – 228Combined sources3
Turni229 – 231Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CWMX-ray1.95A/D1-236[»]
2OW4X-ray1.60A1-236[»]
2P34X-ray2.10A/B/C/D1-236[»]
2P37X-ray2.10A/B/C/D1-236[»]
SMRiP81364.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81364.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 99Carbohydrate bindingBy similarity2

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ADTIVAVELD TYPNTDVGDP SYPHXXXXXX SVRXXTAKWN MQNGKVGTAH
60 70 80 90 100
ISYNSVGKRL SAVVSYPNGD SATVSYDVDL DNVLPEWVRV GLSASTGLYK
110 120 130 140 150
ETNTILSWSF TSKLKSNSTH ETNALHFMFN QFTKDQKDLI LQSDATTGTD
160 170 180 190 200
GNLXXTRVSS NGPSQGSTVG RALFYAPVHI WESSATVAGF DATFXXLIKS
210 220 230
PDSHPADGIA FFISNIDSSI PSGSTGRLLG LFPDAN
Length:236
Mass (Da):25,364
Last modified:December 15, 1998 - v1
Checksum:iD67791C3B0EB150A
GO

Sequence databases

PIRiB45587.

Cross-referencesi

Sequence databases

PIRiB45587.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CWMX-ray1.95A/D1-236[»]
2OW4X-ray1.60A1-236[»]
2P34X-ray2.10A/B/C/D1-236[»]
2P37X-ray2.10A/B/C/D1-236[»]
SMRiP81364.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP81364.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCONA_CANRO
AccessioniPrimary (citable) accession number: P81364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.