Reviewed, UniProtKB/Swiss-Prot P81347 (THL_CLOPA)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA acetyltransferase
    EC=2.3.1.9
Alternative name(s):
    Acetoacetyl-CoA thiolase
    CP 13

Gene names

Name:

thl

Organism

Clostridium pasteurianum

Taxonomic identifier

1501 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	15 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2 acetyl-CoA = CoA + acetoacetyl-CoA.
Pathway	Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thiolase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA C-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›15	›15	Acetyl-CoA acetyltransferase		PRO_0000206405
Experimental info
	Non-terminal residue	15	1

Sequences

	Sequence		Length	Mass (Da)
	P81347-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 9735820D61BB35FC	FASTA	15	1,498
	10 MKEVVIASAV XTAXG

References

[1]

"Two-dimensional gel electrophoresis separation and N-terminal sequence analysis of proteins from Clostridium pasteurianum W5." Flengsrud R., Skjeldal L. Electrophoresis 19:802-806(1998) [PubMed: 9629918] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: ATCC 6013 / DSM 525 / NCIB 9486 / VKM B-1774 / W5.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.3.1.9. 871.
Family and domain databases
PROSITE	PS00098. THIOLASE_1. Partial match. PS00737. THIOLASE_2. Partial match. PS00099. THIOLASE_3. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THL_CLOPA

Accession

Primary (citable) accession number: P81347

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 24, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)