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P81288

- RS4_GEOSE

UniProt

P81288 - RS4_GEOSE

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Protein
30S ribosomal protein S4
Gene
rpsD
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit By similarity.UniRule annotation
With S5 and S12 plays an important role in translational accuracy By similarity.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S4
Alternative name(s):
BS5
Gene namesi
Name:rpsD
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

  1. small ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 20019930S ribosomal protein S4UniRule annotation
PRO_0000132338Add
BLAST

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi46 – 5914
Turni60 – 623
Helixi65 – 7511
Beta strandi78 – 803
Helixi82 – 9211
Helixi94 – 1007
Beta strandi103 – 1064
Helixi107 – 1159
Beta strandi119 – 1213
Beta strandi138 – 1414
Helixi143 – 1453
Helixi149 – 1568
Beta strandi163 – 1686
Turni169 – 1724
Beta strandi173 – 1764
Turni182 – 1843
Helixi192 – 1998

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C05NMR-A43-200[»]
1C06NMR-A43-200[»]
ProteinModelPortaliP81288.
SMRiP81288. Positions 43-200.

Miscellaneous databases

EvolutionaryTraceiP81288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 15261S4 RNA-binding
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1050.10. 1 hit.
3.10.290.10. 1 hit.
HAMAPiMF_01306_B. Ribosomal_S4_B.
InterProiIPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR005709. Ribosomal_S4_bac-type.
IPR018079. Ribosomal_S4_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01017. rpsD_bact. 1 hit.
PROSITEiPS00632. RIBOSOMAL_S4. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81288-1 [UniParc]FASTAAdd to Basket

« Hide

MARYTGPMWK ISRRLGISLS GTGKELQKRP YPPGQHGPGQ RRKLSEYGLQ    50
LQEKQKLRHM YGVNERQFRK TFEEAGKMPG KHGENFMILL ESRLDNLVYR 100
LGLARTRRQA RQLVTHGHII VDGSRVNIPS YRVKPGQTIA VREKSRNLQV 150
IKEALEANNY IPDYLSFDPE KMEGTYTRLP ERSELPAEIN EALIVEFYSR 200
Length:200
Mass (Da):23,196
Last modified:January 23, 2007 - v3
Checksum:i8DBED1D1EE76A3F0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411Missing AA sequence 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1C05 NMR - A 43-200 [» ]
1C06 NMR - A 43-200 [» ]
ProteinModelPortali P81288.
SMRi P81288. Positions 43-200.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P81288.

Family and domain databases

Gene3Di 1.10.1050.10. 1 hit.
3.10.290.10. 1 hit.
HAMAPi MF_01306_B. Ribosomal_S4_B.
InterProi IPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR005709. Ribosomal_S4_bac-type.
IPR018079. Ribosomal_S4_CS.
IPR002942. S4_RNA-bd.
[Graphical view ]
PANTHERi PTHR11831. PTHR11831. 1 hit.
Pfami PF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01017. rpsD_bact. 1 hit.
PROSITEi PS00632. RIBOSOMAL_S4. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif."
    Davies C., Gerstner R.B., Draper D.E., Ramakrishnan V., White S.W.
    EMBO J. 17:4545-4558(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 42-200.
  2. "Primary structures of ribosomal proteins from the archaebacterium Halobacterium marismortui and the eubacterium Bacillus stearothermophilus."
    Arndt E., Scholzen T., Kromer W., Hatakeyama T., Kimura M.
    Biochimie 73:657-668(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-200.
  3. "Procaryotic ribosomal proteins: N-terminal sequence homologies and structural correspondence of 30 S ribosomal proteins from Escherichia coli and Bacillus stearothermophilus."
    Yaguchi M., Matheson A.T., Visentin L.P.
    FEBS Lett. 46:296-300(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16.
    Strain: DSM 13240 / CIP 106956 / 10.
  4. "Isolation and characterization of Bacillus stearothermophilus 30S and 50S ribosomal protein mutations."
    Schnier J., Gewitz H.S., Behrens S.E., Lee A., Ginther C., Leighton T.
    J. Bacteriol. 172:7306-7309(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOLATION OF STREPTOMYCIN INDEPENDENT STRAINS.
    Strain: 799.
  5. "Recognition of 16S rRNA by ribosomal protein S4 from Bacillus stearothermophilus."
    Gerstner R.B., Pak Y., Draper D.E.
    Biochemistry 40:7165-7173(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: BINDING TO RRNA.
  6. "Refining the overall structure and subdomain orientation of ribosomal protein S4 delta41 with dipolar couplings measured by NMR in uniaxial liquid crystalline phases."
    Markus M.A., Gerstner R.B., Draper D.E., Torchia D.A.
    J. Mol. Biol. 292:375-387(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 42-199.
  7. "Structural preordering in the N-terminal region of ribosomal protein S4 revealed by heteronuclear NMR spectroscopy."
    Sayers E.W., Gerstner R.B., Draper D.E., Torchia D.A.
    Biochemistry 39:13602-13613(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiRS4_GEOSE
AccessioniPrimary (citable) accession number: P81288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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