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P81277 (PRRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prolactin-releasing peptide

Short name=PrRP
Alternative name(s):
Prolactin-releasing hormone
Gene names
Name:PRLH
Synonyms:PRH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

Subcellular location

Secreted.

Tissue specificity

Medulla oblongata and hypothalamus. Ref.3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Peptide23 – 5331Prolactin-releasing peptide PrRP31
PRO_0000022144
Peptide34 – 5320Prolactin-releasing peptide PrRP20
PRO_0000022145
Propeptide58 – 8730
PRO_0000022146

Amino acid modifications

Modified residue531Phenylalanine amide By similarity

Sequences

Sequence LengthMass (Da)Tools
P81277 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 229A2F3F50CF981B

FASTA879,639
        10         20         30         40         50         60 
MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL 

        70         80 
GDVPKPGLRP RLTCFPLEGG AMSSQDG 

« Hide

References

« Hide 'large scale' references
[1]"A prolactin-releasing peptide in the brain."
Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S., Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M., Kurokawa T., Nishimura O., Onda H., Fujino M.
Nature 393:272-276(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor."
Fujii R., Fukusumi S., Hosoya M., Kawamata Y., Habata Y., Hinuma S., Sekiguchi M., Kitada C., Kurokawa T., Nishimura O., Onda H., Sumino Y., Fujino M.
Regul. Pept. 83:1-10(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015419 mRNA. Translation: BAA29027.1.
BC069081 mRNA. Translation: AAH69081.1.
BC069284 mRNA. Translation: AAH69284.1.
RefSeqNP_056977.1. NM_015893.1.
UniGeneHs.247710.

3D structure databases

ProteinModelPortalP81277.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000165524.

PTM databases

PhosphoSiteP81277.

Polymorphism databases

DMDM8134649.

Proteomic databases

PaxDbP81277.
PRIDEP81277.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000165524; ENSP00000165524; ENSG00000071677.
GeneID51052.
KEGGhsa:51052.
UCSCuc010znl.2. human.

Organism-specific databases

CTD51052.
GeneCardsGC02P238475.
HGNCHGNC:17945. PRLH.
HPAHPA014768.
MIM602663. gene.
neXtProtNX_P81277.
PharmGKBPA134927756.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25548.
HOGENOMHOG000115720.
HOVERGENHBG004601.
InParanoidP81277.
KOK05269.
OMAHSMEIRT.
OrthoDBEOG7X3QVH.
PhylomeDBP81277.
TreeFamTF330717.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP81277.
BgeeP81277.
CleanExHS_PRLH.
GenevestigatorP81277.

Family and domain databases

InterProIPR026194. PrRP.
[Graphical view]
PANTHERPTHR17206. PTHR17206. 1 hit.
PfamPF15172. Prolactin_RP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPRLH.
Prolactin-releasing_peptide.
GenomeRNAi51052.
NextBio53612.
PROP81277.
SOURCESearch...

Entry information

Entry namePRRP_HUMAN
AccessionPrimary (citable) accession number: P81277
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM