P81277 (PRRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prolactin-releasing peptide
Short name=PrRP

Alternative name(s):
Prolactin-releasing hormone

Cleaved into the following 2 chains:

1. Prolactin-releasing peptide PrRP31
2. Prolactin-releasing peptide PrRP20

Gene names

Name:	PRLH
Synonyms:	PRH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.
Subcellular location	Secreted.
Tissue specificity	Medulla oblongata and hypothalamus. Ref.3

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara autonomic nervous system development Inferred from electronic annotation. Source: Compara energy reserve metabolic process Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from electronic annotation. Source: Compara lipid metabolic process Inferred from electronic annotation. Source: Compara reduction of food intake in response to dietary excess Inferred from electronic annotation. Source: Compara response to glucose stimulus Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara tissue homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular region Traceable author statement. Source: Reactome
Molecular_function	hormone activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Peptide	23 – 53	31	Prolactin-releasing peptide PrRP31		PRO_0000022144
	Peptide	34 – 53	20	Prolactin-releasing peptide PrRP20		PRO_0000022145
	Propeptide	58 – 87	30			PRO_0000022146
Amino acid modifications
	Modified residue	53	1	Phenylalanine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81277 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 229A2F3F50CF981B	FASTA	87	9,639
	10 20 30 40 50 60 MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL 70 80 GDVPKPGLRP RLTCFPLEGG AMSSQDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A prolactin-releasing peptide in the brain." Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S., Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M., Kurokawa T., Nishimura O., Onda H., Fujino M. Nature 393:272-276(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor." Fujii R., Fukusumi S., Hosoya M., Kawamata Y., Habata Y., Hinuma S., Sekiguchi M., Kitada C., Kurokawa T., Nishimura O., Onda H., Sumino Y., Fujino M. Regul. Pept. 83:1-10(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB015419 mRNA. Translation: BAA29027.1. BC069081 mRNA. Translation: AAH69081.1. BC069284 mRNA. Translation: AAH69284.1.
IPI	IPI00026444.
RefSeq	NP_056977.1. NM_015893.1.
UniGene	Hs.247710.
3D structure databases
ProteinModelPortal	P81277.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000165524.
PTM databases
PhosphoSite	P81277.
Polymorphism databases
DMDM	8134649.
Proteomic databases
PaxDb	P81277.
PRIDE	P81277.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000165524; ENSP00000165524; ENSG00000071677.
GeneID	51052.
KEGG	hsa:51052.
UCSC	uc010znl.2. human.
Organism-specific databases
CTD	51052.
GeneCards	GC02P238475.
HGNC	HGNC:17945. PRLH.
HPA	HPA014768.
MIM	602663. gene.
neXtProt	NX_P81277.
PharmGKB	PA134927756.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25548.
HOGENOM	HOG000115720.
HOVERGEN	HBG004601.
InParanoid	P81277.
KO	K05269.
OMA	HSMEIRT.
OrthoDB	EOG4MW87S.
PhylomeDB	P81277.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P81277.
Bgee	P81277.
CleanEx	HS_PRLH.
Genevestigator	P81277.
GermOnline	ENSG00000071677. Homo sapiens.
Family and domain databases
InterPro	IPR026194. PrRP. [Graphical view]
PANTHER	PTHR17206. PTHR17206. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	51052.
NextBio	53612.
SOURCE	Search...

Entry information

Entry name

PRRP_HUMAN

Accession

Primary (citable) accession number: P81277

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.