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Protein

Prolactin-releasing peptide

Gene

PRLH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

GO - Molecular functioni

  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: Ensembl
  • prolactin-releasing peptide receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-releasing peptide
Short name:
PrRP
Alternative name(s):
Prolactin-releasing hormone
Cleaved into the following 2 chains:
Gene namesi
Name:PRLH
Synonyms:PRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17945. PRLH.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51052.
OpenTargetsiENSG00000071677.
PharmGKBiPA134927756.

Polymorphism and mutation databases

BioMutaiPRLH.
DMDMi8134649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
PeptideiPRO_000002214423 – 53Prolactin-releasing peptide PrRP31Add BLAST31
PeptideiPRO_000002214534 – 53Prolactin-releasing peptide PrRP20Add BLAST20
PropeptideiPRO_000002214658 – 87Add BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP81277.
PRIDEiP81277.

PTM databases

iPTMnetiP81277.
PhosphoSitePlusiP81277.

Expressioni

Tissue specificityi

Medulla oblongata and hypothalamus.1 Publication

Gene expression databases

BgeeiENSG00000071677.
CleanExiHS_PRLH.
ExpressionAtlasiP81277. baseline and differential.
GenevisibleiP81277. HS.

Organism-specific databases

HPAiHPA014768.

Interactioni

GO - Molecular functioni

  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: Ensembl
  • prolactin-releasing peptide receptor binding Source: Ensembl

Protein-protein interaction databases

STRINGi9606.ENSP00000165524.

Structurei

3D structure databases

ProteinModelPortaliP81277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J49T. Eukaryota.
ENOG4111800. LUCA.
GeneTreeiENSGT00390000005489.
HOGENOMiHOG000115720.
HOVERGENiHBG004601.
InParanoidiP81277.
KOiK05269.
OMAiINPAWYA.
OrthoDBiEOG091G191K.
PhylomeDBiP81277.
TreeFamiTF330717.

Family and domain databases

InterProiView protein in InterPro
IPR026194. PrRP.
PANTHERiPTHR17206. PTHR17206. 1 hit.
PfamiView protein in Pfam
PF15172. Prolactin_RP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV
60 70 80
GRFGRRRATL GDVPKPGLRP RLTCFPLEGG AMSSQDG
Length:87
Mass (Da):9,639
Last modified:June 1, 1998 - v1
Checksum:i229A2F3F50CF981B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015419 mRNA. Translation: BAA29027.1.
BC069081 mRNA. Translation: AAH69081.1.
BC069284 mRNA. Translation: AAH69284.1.
CCDSiCCDS2519.1.
RefSeqiNP_056977.1. NM_015893.1.
UniGeneiHs.247710.

Genome annotation databases

EnsembliENST00000165524; ENSP00000165524; ENSG00000071677.
GeneIDi51052.
KEGGihsa:51052.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRRP_HUMAN
AccessioniPrimary (citable) accession number: P81277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 10, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot