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P81277

- PRRP_HUMAN

UniProt

P81277 - PRRP_HUMAN

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Protein

Prolactin-releasing peptide

Gene
PRLH, PRH
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

GO - Molecular functioni

  1. hormone activity Source: ProtInc

GO - Biological processi

  1. autonomic nervous system development Source: Ensembl
  2. energy reserve metabolic process Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: Ensembl
  5. lipid metabolic process Source: Ensembl
  6. reduction of food intake in response to dietary excess Source: Ensembl
  7. response to glucose Source: Ensembl
  8. response to insulin Source: Ensembl
  9. tissue homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-releasing peptide
Short name:
PrRP
Alternative name(s):
Prolactin-releasing hormone
Cleaved into the following 2 chains:
Gene namesi
Name:PRLH
Synonyms:PRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17945. PRLH.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarityAdd
BLAST
Peptidei23 – 5331Prolactin-releasing peptide PrRP31PRO_0000022144Add
BLAST
Peptidei34 – 5320Prolactin-releasing peptide PrRP20PRO_0000022145Add
BLAST
Propeptidei58 – 8730PRO_0000022146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531Phenylalanine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP81277.
PRIDEiP81277.

PTM databases

PhosphoSiteiP81277.

Expressioni

Tissue specificityi

Medulla oblongata and hypothalamus.1 Publication

Gene expression databases

ArrayExpressiP81277.
BgeeiP81277.
CleanExiHS_PRLH.
GenevestigatoriP81277.

Organism-specific databases

HPAiHPA014768.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000165524.

Structurei

3D structure databases

ProteinModelPortaliP81277.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25548.
HOGENOMiHOG000115720.
HOVERGENiHBG004601.
InParanoidiP81277.
KOiK05269.
OMAiHSMEIRT.
OrthoDBiEOG7X3QVH.
PhylomeDBiP81277.
TreeFamiTF330717.

Family and domain databases

InterProiIPR026194. PrRP.
[Graphical view]
PANTHERiPTHR17206. PTHR17206. 1 hit.
PfamiPF15172. Prolactin_RP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81277-1 [UniParc]FASTAAdd to Basket

« Hide

MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV   50
GRFGRRRATL GDVPKPGLRP RLTCFPLEGG AMSSQDG 87
Length:87
Mass (Da):9,639
Last modified:June 1, 1998 - v1
Checksum:i229A2F3F50CF981B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015419 mRNA. Translation: BAA29027.1.
BC069081 mRNA. Translation: AAH69081.1.
BC069284 mRNA. Translation: AAH69284.1.
CCDSiCCDS2519.1.
RefSeqiNP_056977.1. NM_015893.1.
UniGeneiHs.247710.

Genome annotation databases

EnsembliENST00000165524; ENSP00000165524; ENSG00000071677.
GeneIDi51052.
KEGGihsa:51052.
UCSCiuc010znl.2. human.

Polymorphism databases

DMDMi8134649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015419 mRNA. Translation: BAA29027.1 .
BC069081 mRNA. Translation: AAH69081.1 .
BC069284 mRNA. Translation: AAH69284.1 .
CCDSi CCDS2519.1.
RefSeqi NP_056977.1. NM_015893.1.
UniGenei Hs.247710.

3D structure databases

ProteinModelPortali P81277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000165524.

PTM databases

PhosphoSitei P81277.

Polymorphism databases

DMDMi 8134649.

Proteomic databases

PaxDbi P81277.
PRIDEi P81277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000165524 ; ENSP00000165524 ; ENSG00000071677 .
GeneIDi 51052.
KEGGi hsa:51052.
UCSCi uc010znl.2. human.

Organism-specific databases

CTDi 51052.
GeneCardsi GC02P238475.
HGNCi HGNC:17945. PRLH.
HPAi HPA014768.
MIMi 602663. gene.
neXtProti NX_P81277.
PharmGKBi PA134927756.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25548.
HOGENOMi HOG000115720.
HOVERGENi HBG004601.
InParanoidi P81277.
KOi K05269.
OMAi HSMEIRT.
OrthoDBi EOG7X3QVH.
PhylomeDBi P81277.
TreeFami TF330717.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.

Miscellaneous databases

GeneWikii PRLH.
Prolactin-releasing_peptide.
GenomeRNAii 51052.
NextBioi 53612.
PROi P81277.
SOURCEi Search...

Gene expression databases

ArrayExpressi P81277.
Bgeei P81277.
CleanExi HS_PRLH.
Genevestigatori P81277.

Family and domain databases

InterProi IPR026194. PrRP.
[Graphical view ]
PANTHERi PTHR17206. PTHR17206. 1 hit.
Pfami PF15172. Prolactin_RP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPRRP_HUMAN
AccessioniPrimary (citable) accession number: P81277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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