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Protein

Prolactin-releasing peptide

Gene

PRLH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

GO - Molecular functioni

  1. hormone activity Source: ProtInc

GO - Biological processi

  1. autonomic nervous system development Source: Ensembl
  2. energy reserve metabolic process Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: Ensembl
  5. lipid metabolic process Source: Ensembl
  6. reduction of food intake in response to dietary excess Source: Ensembl
  7. regulation of multicellular organism growth Source: Ensembl
  8. response to glucose Source: Ensembl
  9. response to insulin Source: Ensembl
  10. tissue homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-releasing peptide
Short name:
PrRP
Alternative name(s):
Prolactin-releasing hormone
Cleaved into the following 2 chains:
Gene namesi
Name:PRLH
Synonyms:PRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17945. PRLH.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134927756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Peptidei23 – 5331Prolactin-releasing peptide PrRP31PRO_0000022144Add
BLAST
Peptidei34 – 5320Prolactin-releasing peptide PrRP20PRO_0000022145Add
BLAST
Propeptidei58 – 8730PRO_0000022146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP81277.
PRIDEiP81277.

PTM databases

PhosphoSiteiP81277.

Expressioni

Tissue specificityi

Medulla oblongata and hypothalamus.1 Publication

Gene expression databases

BgeeiP81277.
CleanExiHS_PRLH.
ExpressionAtlasiP81277. baseline.
GenevestigatoriP81277.

Organism-specific databases

HPAiHPA014768.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000165524.

Structurei

3D structure databases

ProteinModelPortaliP81277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25548.
HOGENOMiHOG000115720.
HOVERGENiHBG004601.
InParanoidiP81277.
KOiK05269.
OMAiHSMEIRT.
OrthoDBiEOG7X3QVH.
PhylomeDBiP81277.
TreeFamiTF330717.

Family and domain databases

InterProiIPR026194. PrRP.
[Graphical view]
PANTHERiPTHR17206. PTHR17206. 1 hit.
PfamiPF15172. Prolactin_RP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV
60 70 80
GRFGRRRATL GDVPKPGLRP RLTCFPLEGG AMSSQDG
Length:87
Mass (Da):9,639
Last modified:May 31, 1998 - v1
Checksum:i229A2F3F50CF981B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015419 mRNA. Translation: BAA29027.1.
BC069081 mRNA. Translation: AAH69081.1.
BC069284 mRNA. Translation: AAH69284.1.
CCDSiCCDS2519.1.
RefSeqiNP_056977.1. NM_015893.1.
UniGeneiHs.247710.

Genome annotation databases

EnsembliENST00000165524; ENSP00000165524; ENSG00000071677.
GeneIDi51052.
KEGGihsa:51052.
UCSCiuc010znl.2. human.

Polymorphism databases

DMDMi8134649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015419 mRNA. Translation: BAA29027.1.
BC069081 mRNA. Translation: AAH69081.1.
BC069284 mRNA. Translation: AAH69284.1.
CCDSiCCDS2519.1.
RefSeqiNP_056977.1. NM_015893.1.
UniGeneiHs.247710.

3D structure databases

ProteinModelPortaliP81277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000165524.

PTM databases

PhosphoSiteiP81277.

Polymorphism databases

DMDMi8134649.

Proteomic databases

PaxDbiP81277.
PRIDEiP81277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000165524; ENSP00000165524; ENSG00000071677.
GeneIDi51052.
KEGGihsa:51052.
UCSCiuc010znl.2. human.

Organism-specific databases

CTDi51052.
GeneCardsiGC02P238475.
HGNCiHGNC:17945. PRLH.
HPAiHPA014768.
MIMi602663. gene.
neXtProtiNX_P81277.
PharmGKBiPA134927756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25548.
HOGENOMiHOG000115720.
HOVERGENiHBG004601.
InParanoidiP81277.
KOiK05269.
OMAiHSMEIRT.
OrthoDBiEOG7X3QVH.
PhylomeDBiP81277.
TreeFamiTF330717.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.

Miscellaneous databases

GeneWikiiPRLH.
Prolactin-releasing_peptide.
GenomeRNAii51052.
NextBioi53612.
PROiP81277.
SOURCEiSearch...

Gene expression databases

BgeeiP81277.
CleanExiHS_PRLH.
ExpressionAtlasiP81277. baseline.
GenevestigatoriP81277.

Family and domain databases

InterProiIPR026194. PrRP.
[Graphical view]
PANTHERiPTHR17206. PTHR17206. 1 hit.
PfamiPF15172. Prolactin_RP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPRRP_HUMAN
AccessioniPrimary (citable) accession number: P81277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: May 31, 1998
Last modified: January 6, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.