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P81277

- PRRP_HUMAN

UniProt

P81277 - PRRP_HUMAN

Protein

Prolactin-releasing peptide

Gene

PRLH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc

    GO - Biological processi

    1. autonomic nervous system development Source: Ensembl
    2. energy reserve metabolic process Source: Ensembl
    3. fat cell differentiation Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: Ensembl
    5. lipid metabolic process Source: Ensembl
    6. reduction of food intake in response to dietary excess Source: Ensembl
    7. response to glucose Source: Ensembl
    8. response to insulin Source: Ensembl
    9. tissue homeostasis Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prolactin-releasing peptide
    Short name:
    PrRP
    Alternative name(s):
    Prolactin-releasing hormone
    Cleaved into the following 2 chains:
    Gene namesi
    Name:PRLH
    Synonyms:PRH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17945. PRLH.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134927756.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Peptidei23 – 5331Prolactin-releasing peptide PrRP31PRO_0000022144Add
    BLAST
    Peptidei34 – 5320Prolactin-releasing peptide PrRP20PRO_0000022145Add
    BLAST
    Propeptidei58 – 8730PRO_0000022146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531Phenylalanine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP81277.
    PRIDEiP81277.

    PTM databases

    PhosphoSiteiP81277.

    Expressioni

    Tissue specificityi

    Medulla oblongata and hypothalamus.1 Publication

    Gene expression databases

    ArrayExpressiP81277.
    BgeeiP81277.
    CleanExiHS_PRLH.
    GenevestigatoriP81277.

    Organism-specific databases

    HPAiHPA014768.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000165524.

    Structurei

    3D structure databases

    ProteinModelPortaliP81277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG25548.
    HOGENOMiHOG000115720.
    HOVERGENiHBG004601.
    InParanoidiP81277.
    KOiK05269.
    OMAiHSMEIRT.
    OrthoDBiEOG7X3QVH.
    PhylomeDBiP81277.
    TreeFamiTF330717.

    Family and domain databases

    InterProiIPR026194. PrRP.
    [Graphical view]
    PANTHERiPTHR17206. PTHR17206. 1 hit.
    PfamiPF15172. Prolactin_RP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P81277-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV   50
    GRFGRRRATL GDVPKPGLRP RLTCFPLEGG AMSSQDG 87
    Length:87
    Mass (Da):9,639
    Last modified:June 1, 1998 - v1
    Checksum:i229A2F3F50CF981B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015419 mRNA. Translation: BAA29027.1.
    BC069081 mRNA. Translation: AAH69081.1.
    BC069284 mRNA. Translation: AAH69284.1.
    CCDSiCCDS2519.1.
    RefSeqiNP_056977.1. NM_015893.1.
    UniGeneiHs.247710.

    Genome annotation databases

    EnsembliENST00000165524; ENSP00000165524; ENSG00000071677.
    GeneIDi51052.
    KEGGihsa:51052.
    UCSCiuc010znl.2. human.

    Polymorphism databases

    DMDMi8134649.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015419 mRNA. Translation: BAA29027.1 .
    BC069081 mRNA. Translation: AAH69081.1 .
    BC069284 mRNA. Translation: AAH69284.1 .
    CCDSi CCDS2519.1.
    RefSeqi NP_056977.1. NM_015893.1.
    UniGenei Hs.247710.

    3D structure databases

    ProteinModelPortali P81277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000165524.

    PTM databases

    PhosphoSitei P81277.

    Polymorphism databases

    DMDMi 8134649.

    Proteomic databases

    PaxDbi P81277.
    PRIDEi P81277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000165524 ; ENSP00000165524 ; ENSG00000071677 .
    GeneIDi 51052.
    KEGGi hsa:51052.
    UCSCi uc010znl.2. human.

    Organism-specific databases

    CTDi 51052.
    GeneCardsi GC02P238475.
    HGNCi HGNC:17945. PRLH.
    HPAi HPA014768.
    MIMi 602663. gene.
    neXtProti NX_P81277.
    PharmGKBi PA134927756.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25548.
    HOGENOMi HOG000115720.
    HOVERGENi HBG004601.
    InParanoidi P81277.
    KOi K05269.
    OMAi HSMEIRT.
    OrthoDBi EOG7X3QVH.
    PhylomeDBi P81277.
    TreeFami TF330717.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.

    Miscellaneous databases

    GeneWikii PRLH.
    Prolactin-releasing_peptide.
    GenomeRNAii 51052.
    NextBioi 53612.
    PROi P81277.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P81277.
    Bgeei P81277.
    CleanExi HS_PRLH.
    Genevestigatori P81277.

    Family and domain databases

    InterProi IPR026194. PrRP.
    [Graphical view ]
    PANTHERi PTHR17206. PTHR17206. 1 hit.
    Pfami PF15172. Prolactin_RP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPRRP_HUMAN
    AccessioniPrimary (citable) accession number: P81277
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3