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P81274

- GPSM2_HUMAN

UniProt

P81274 - GPSM2_HUMAN

Protein

G-protein-signaling modulator 2

Gene

GPSM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 3 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.1 Publication

    GO - Molecular functioni

    1. GTPase regulator activity Source: InterPro
    2. identical protein binding Source: IntAct
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. establishment of mitotic spindle orientation Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. lung epithelial cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein-signaling modulator 2
    Alternative name(s):
    Mosaic protein LGN
    Gene namesi
    Name:GPSM2
    Synonyms:LGN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29501. GPSM2.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcell cortex 1 Publication
    Note: Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cell cortex Source: UniProtKB-SubCell
    3. cytoplasm Source: HPA
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Chudley-McCullough syndrome (CMCS) [MIM:604213]: An autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia. Some patients have hydrocephalus. Psychomotor development is normal.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Deafness

    Organism-specific databases

    MIMi604213. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    314597. Chudley-McCullough syndrome.
    PharmGKBiPA134993615.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684G-protein-signaling modulator 2PRO_0000106358Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei132 – 1321Phosphoserine; by PKGSequence Analysis
    Modified residuei352 – 3521Phosphoserine; by PKGSequence Analysis
    Modified residuei408 – 4081Phosphoserine1 Publication
    Modified residuei483 – 4831Phosphoserine1 Publication
    Modified residuei486 – 4861Phosphothreonine1 Publication
    Modified residuei501 – 5011Phosphoserine; by PKCSequence Analysis
    Modified residuei541 – 5411Phosphoserine1 Publication
    Modified residuei565 – 5651Phosphoserine1 Publication
    Modified residuei607 – 6071Phosphoserine; by PKGSequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP81274.
    PaxDbiP81274.
    PRIDEiP81274.

    PTM databases

    PhosphoSiteiP81274.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.

    Gene expression databases

    ArrayExpressiP81274.
    BgeeiP81274.
    CleanExiHS_GPSM2.
    GenevestigatoriP81274.

    Organism-specific databases

    HPAiCAB018962.
    HPA007327.
    HPA008408.

    Interactioni

    Subunit structurei

    Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself7EBI-618655,EBI-618655
    GNAI1P630963EBI-618655,EBI-618639
    NUMA1Q149806EBI-618655,EBI-521611

    Protein-protein interaction databases

    BioGridi118949. 8 interactions.
    DIPiDIP-399N.
    IntActiP81274. 4 interactions.
    MINTiMINT-3023522.
    STRINGi9606.ENSP00000264126.

    Structurei

    Secondary structure

    1
    684
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 3613
    Helixi40 – 5314
    Helixi58 – 7417
    Helixi78 – 9417
    Helixi98 – 11417
    Helixi118 – 13518
    Helixi138 – 15720
    Helixi172 – 19423
    Helixi198 – 21518
    Helixi218 – 23417
    Helixi238 – 25417
    Helixi258 – 27417
    Helixi278 – 29417
    Helixi298 – 31417
    Helixi318 – 33518
    Helixi338 – 35417
    Helixi358 – 37619

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SF4X-ray2.60A/B/C20-421[»]
    ProteinModelPortaliP81274.
    SMRiP81274. Positions 20-381, 594-648.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 5734TPR 1Add
    BLAST
    Repeati62 – 9534TPR 2Add
    BLAST
    Repeati102 – 13534TPR 3Add
    BLAST
    Repeati142 – 18443TPR 4Add
    BLAST
    Repeati202 – 23534TPR 5Add
    BLAST
    Repeati242 – 27534TPR 6Add
    BLAST
    Repeati282 – 31534TPR 7Add
    BLAST
    Repeati322 – 35534TPR 8Add
    BLAST
    Domaini489 – 51123GoLoco 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini544 – 56623GoLoco 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini594 – 61623GoLoco 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini628 – 65023GoLoco 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GPSM family.Curated
    Contains 4 GoLoco domains.PROSITE-ProRule annotation
    Contains 8 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000231543.
    HOVERGENiHBG051823.
    InParanoidiP81274.
    KOiK15837.
    OMAiEYYEANL.
    OrthoDBiEOG7WHH8W.
    PhylomeDBiP81274.
    TreeFamiTF328344.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR003109. GoLoco_motif.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF02188. GoLoco. 4 hits.
    PF00515. TPR_1. 5 hits.
    PF13176. TPR_7. 1 hit.
    [Graphical view]
    SMARTiSM00390. GoLoco. 4 hits.
    SM00028. TPR. 6 hits.
    [Graphical view]
    PROSITEiPS50877. GOLOCO. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P81274-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA    50
    VQVGTEDLKT LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG 100
    EAKASGNLGN TLKVLGNFDE AIVCCQRHLD ISRELNDKVG EARALYNLGN 150
    VYHAKGKSFG CPGPQDVGEF PEEVRDALQA AVDFYEENLS LVTALGDRAA 200
    QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA ERRAYSNLGN 250
    AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK 300
    AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE 350
    ISREVGDKSG ELTARLNLSD LQMVLGLSYS TNNSIMSENT EIDSSLNGVR 400
    PKLGRRHSME NMELMKLTPE KVQNWNSEIL AKQKPLIAKP SAKLLFVNRL 450
    KGKKYKTNSS TKVLQDASNS IDHRIPNSQR KISADTIGDE GFFDLLSRFQ 500
    SNRMDDQRCC LQEKNCHTAS TTTSSTPPKM MLKTSSVPVV SPNTDEFLDL 550
    LASSQSRRLD DQRASFSNLP GLRLTQNSQS VLSHLMTNDN KEADEDFFDI 600
    LVKCQGSRLD DQRCAPPPAT TKGPTVPDED FFSLILRSQG KRMDEQRVLL 650
    QRDQNRDTDF GLKDFLQNNA LLEFKNSGKK SADH 684
    Length:684
    Mass (Da):76,662
    Last modified:April 20, 2010 - v3
    Checksum:iD007A4765F57CB90
    GO

    Sequence cautioni

    The sequence AAB40385.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH27732.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti400 – 4001R → L in AAB40385. (PubMed:8973305)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U54999 mRNA. Translation: AAB40385.1. Different initiation.
    AB445462 mRNA. Translation: BAH84760.1.
    AL449266 Genomic DNA. Translation: CAI14361.1.
    CH471122 Genomic DNA. Translation: EAW56340.1.
    BC027732 mRNA. Translation: AAH27732.1. Different initiation.
    AY136740 mRNA. Translation: AAN01266.1.
    CR456786 mRNA. Translation: CAG33067.1.
    CCDSiCCDS792.2.
    PIRiJC5334. G02540.
    RefSeqiNP_037428.3. NM_013296.4.
    XP_005270844.1. XM_005270787.1.
    XP_006710651.1. XM_006710588.1.
    UniGeneiHs.584901.
    Hs.658489.

    Genome annotation databases

    EnsembliENST00000264126; ENSP00000264126; ENSG00000121957.
    ENST00000406462; ENSP00000385510; ENSG00000121957.
    GeneIDi29899.
    KEGGihsa:29899.
    UCSCiuc010ovc.2. human.

    Polymorphism databases

    DMDMi294862507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U54999 mRNA. Translation: AAB40385.1 . Different initiation.
    AB445462 mRNA. Translation: BAH84760.1 .
    AL449266 Genomic DNA. Translation: CAI14361.1 .
    CH471122 Genomic DNA. Translation: EAW56340.1 .
    BC027732 mRNA. Translation: AAH27732.1 . Different initiation.
    AY136740 mRNA. Translation: AAN01266.1 .
    CR456786 mRNA. Translation: CAG33067.1 .
    CCDSi CCDS792.2.
    PIRi JC5334. G02540.
    RefSeqi NP_037428.3. NM_013296.4.
    XP_005270844.1. XM_005270787.1.
    XP_006710651.1. XM_006710588.1.
    UniGenei Hs.584901.
    Hs.658489.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SF4 X-ray 2.60 A/B/C 20-421 [» ]
    ProteinModelPortali P81274.
    SMRi P81274. Positions 20-381, 594-648.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118949. 8 interactions.
    DIPi DIP-399N.
    IntActi P81274. 4 interactions.
    MINTi MINT-3023522.
    STRINGi 9606.ENSP00000264126.

    PTM databases

    PhosphoSitei P81274.

    Polymorphism databases

    DMDMi 294862507.

    Proteomic databases

    MaxQBi P81274.
    PaxDbi P81274.
    PRIDEi P81274.

    Protocols and materials databases

    DNASUi 29899.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264126 ; ENSP00000264126 ; ENSG00000121957 .
    ENST00000406462 ; ENSP00000385510 ; ENSG00000121957 .
    GeneIDi 29899.
    KEGGi hsa:29899.
    UCSCi uc010ovc.2. human.

    Organism-specific databases

    CTDi 29899.
    GeneCardsi GC01P109417.
    HGNCi HGNC:29501. GPSM2.
    HPAi CAB018962.
    HPA007327.
    HPA008408.
    MIMi 604213. phenotype.
    609245. gene.
    neXtProti NX_P81274.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    314597. Chudley-McCullough syndrome.
    PharmGKBi PA134993615.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000231543.
    HOVERGENi HBG051823.
    InParanoidi P81274.
    KOi K15837.
    OMAi EYYEANL.
    OrthoDBi EOG7WHH8W.
    PhylomeDBi P81274.
    TreeFami TF328344.

    Miscellaneous databases

    GeneWikii GPSM2.
    GenomeRNAii 29899.
    NextBioi 52462.
    PROi P81274.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P81274.
    Bgeei P81274.
    CleanExi HS_GPSM2.
    Genevestigatori P81274.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR003109. GoLoco_motif.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF02188. GoLoco. 4 hits.
    PF00515. TPR_1. 5 hits.
    PF13176. TPR_7. 1 hit.
    [Graphical view ]
    SMARTi SM00390. GoLoco. 4 hits.
    SM00028. TPR. 6 hits.
    [Graphical view ]
    PROSITEi PS50877. GOLOCO. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2."
      Mochizuki N., Cho G., Wen B., Insel P.A.
      Gene 181:39-43(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: B-cell.
    2. "Involvement of C0671 overexpression in breast cancer cell growth."
      Katagiri T., Fukukawa C., Nakamura Y.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-684.
      Tissue: Brain.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-684.
    8. "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division."
      Yasumi M., Sakisaka T., Hoshino T., Kimura T., Sakamoto Y., Yamanaka T., Ohno S., Takai Y.
      J. Biol. Chem. 280:6761-6765(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH LLGL2, SUBCELLULAR LOCATION.
      Tissue: Brain.
    9. "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3."
      Izaki T., Kamakura S., Kohjima M., Sumimoto H.
      Biochem. Biophys. Res. Commun. 341:1001-1006(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INSC.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483; THR-486 AND SER-541, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82."
      Walsh T., Shahin H., Elkan-Miller T., Lee M.K., Thornton A.M., Roeb W., Abu Rayyan A., Loulus S., Avraham K.B., King M.C., Kanaan M.
      Am. J. Hum. Genet. 87:90-94(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN CMCS.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408 AND SER-565, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: INVOLVEMENT IN CMCS.

    Entry informationi

    Entry nameiGPSM2_HUMAN
    AccessioniPrimary (citable) accession number: P81274
    Secondary accession number(s): Q5T1N8, Q6IBL7, Q8N0Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 149 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Dysfunction of LGN is associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation and defect in cell division through mis-localization of mitotic splindle regulator protein NuMA.

    Caution

    It is uncertain whether Met-1 or Met-8 is the initiator.Curated
    Mutations in GPSM2 have been identified in people with profound congenital non-syndromic deafness designated as DFNB82 (PubMed:20602914). Subsequent brain imaging of these individuals has revealed frontal polymicrogyria, abnormal corpus callosum, and gray matter heterotopia, consistent with a diagnosis of Chudley-McCullough syndrome (PubMed:22578326).2 Publications

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3