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P81270 (ERG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulator ERG
Gene names
Name:Erg
Synonyms:Erg-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Subunit structure

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1. Ref.5

Subcellular location

Nucleus. Cytoplasm By similarity. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs By similarity.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Setdb1O889743EBI-79647,EBI-79658

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3 (identifier: P81270-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P81270-3)

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.
Isoform 2 (identifier: P81270-2)

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
Isoform 5 (identifier: P81270-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Transcriptional regulator ERG
PRO_0000204104

Regions

Domain120 – 20687PNT
DNA binding318 – 39881ETS

Natural variations

Alternative sequence1 – 1111MIQTVPDPAAH → MAST in isoform 5.
VSP_026585
Alternative sequence232 – 25524Missing in isoform 1.
VSP_007641
Alternative sequence256 – 27823Missing in isoform 2.
VSP_007642

Experimental info

Sequence conflict1751L → Q in BAC37131. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 [UniParc].

Last modified June 20, 2003. Version 2.
Checksum: BF1ADF00A4772F75

FASTA48654,614
        10         20         30         40         50         60 
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 

        70         80         90        100        110        120 
QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM VGSPDTVGMS YGSYMEEKHV 

       130        140        150        160        170        180 
PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLL DVDVLLFQNI DGKELCKMTK 

       190        200        210        220        230        240 
DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN 

       250        260        270        280        290        300 
TSVYPEATQR ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY 

       310        320        330        340        350        360 
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD PDEVARRWGE 

       370        380        390        400        410        420 
RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH GIAQALQPHP PESSLYKYPS 

       430        440        450        460        470        480 
DLPYMGSYHA HPQKMNFVSP HPPALPVTSS SFFASPNPYW NSPTGGIYPN TRLPASHMPS 


HLGTYY 

« Hide

Isoform 1 [UniParc].

Checksum: 0EA419B53ECA5591
Show »

FASTA46252,037
Isoform 2 [UniParc].

Checksum: 510D2BB76663D4A4
Show »

FASTA46351,971
Isoform 5 [UniParc].

Checksum: BAA90BE63412B968
Show »

FASTA47953,843

References

« Hide 'large scale' references
[1]Ozawa R., Noguchi H., Taylor T.D., Takeda T., Hattori M., Sakaki Y.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
Strain: C57BL/6J.
Tissue: Embryo and Medulla oblongata.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[4]"Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression."
Rivera R.R., Stuiver M.H., Steenbergen R., Murre C.
Mol. Cell. Biol. 13:7163-7169(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-452.
[5]"Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor."
Yang L., Xia L., Wu D.Y., Wang H., Chansky H.A., Schubach W.H., Hickstein D.D., Zhang Y.
Oncogene 21:148-152(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SETDB1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB073078 mRNA. Translation: BAB69948.1.
AB073079 mRNA. Translation: BAB69949.1.
AB073080 mRNA. Translation: BAB69950.1.
AK050922 mRNA. Translation: BAC34461.1.
AK078113 mRNA. Translation: BAC37131.1.
BC145850 mRNA. Translation: AAI45851.1.
S66169 mRNA. Translation: AAB28525.1.
CCDSCCDS37411.1. [P81270-1]
PIRA54617.
RefSeqNP_598420.1. NM_133659.2. [P81270-1]
XP_006522957.1. XM_006522894.1. [P81270-1]
XP_006522958.1. XM_006522895.1. [P81270-1]
XP_006522959.1. XM_006522896.1. [P81270-1]
XP_006522962.1. XM_006522899.1. [P81270-2]
XP_006522963.1. XM_006522900.1. [P81270-3]
XP_006522964.1. XM_006522901.1. [P81270-3]
XP_006523225.1. XM_006523162.1. [P81270-1]
XP_006523226.1. XM_006523163.1. [P81270-1]
XP_006523227.1. XM_006523164.1. [P81270-1]
XP_006523230.1. XM_006523167.1. [P81270-2]
XP_006523231.1. XM_006523168.1. [P81270-3]
XP_006523232.1. XM_006523169.1. [P81270-3]
UniGeneMm.164531.

3D structure databases

ProteinModelPortalP81270.
SMRP81270. Positions 112-208, 307-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199504. 4 interactions.
IntActP81270. 2 interactions.
MINTMINT-4122342.

PTM databases

PhosphoSiteP81270.

Proteomic databases

MaxQBP81270.
PaxDbP81270.
PRIDEP81270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077773; ENSMUSP00000076949; ENSMUSG00000040732. [P81270-3]
ENSMUST00000113846; ENSMUSP00000109477; ENSMUSG00000040732. [P81270-1]
ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732. [P81270-2]
ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732. [P81270-4]
GeneID13876.
KEGGmmu:13876.
UCSCuc008acb.1. mouse. [P81270-1]
uc008acc.1. mouse. [P81270-2]

Organism-specific databases

CTD2078.
MGIMGI:95415. Erg.

Phylogenomic databases

eggNOGNOG242679.
GeneTreeENSGT00740000115153.
HOGENOMHOG000290658.
HOVERGENHBG001553.
InParanoidA6H6E7.
KOK09435.
OMANSNCITW.
OrthoDBEOG73V6K8.
PhylomeDBP81270.
TreeFamTF350537.

Gene expression databases

ArrayExpressP81270.
BgeeP81270.
GenevestigatorP81270.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284804.
PROP81270.
SOURCESearch...

Entry information

Entry nameERG_MOUSE
AccessionPrimary (citable) accession number: P81270
Secondary accession number(s): A6H6E7 expand/collapse secondary AC list , Q8C5L4, Q920K7, Q920K8, Q920K9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2003
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot