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P81270

- ERG_MOUSE

UniProt

P81270 - ERG_MOUSE

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Protein

Transcriptional regulator ERG

Gene
Erg, Erg-3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi318 – 39881ETSAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  3. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ERG
Gene namesi
Name:Erg
Synonyms:Erg-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:95415. Erg.

Subcellular locationi

Nucleus. Cytoplasm By similarity
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: RefGenome
  3. ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Transcriptional regulator ERGPRO_0000204104Add
BLAST

Proteomic databases

MaxQBiP81270.
PaxDbiP81270.
PRIDEiP81270.

PTM databases

PhosphoSiteiP81270.

Expressioni

Gene expression databases

ArrayExpressiP81270.
BgeeiP81270.
GenevestigatoriP81270.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Setdb1O889743EBI-79647,EBI-79658

Protein-protein interaction databases

BioGridi199504. 4 interactions.
IntActiP81270. 2 interactions.
MINTiMINT-4122342.

Structurei

3D structure databases

ProteinModelPortaliP81270.
SMRiP81270. Positions 112-208, 307-408.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 20687PNTAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG242679.
GeneTreeiENSGT00740000115153.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiA6H6E7.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG73V6K8.
PhylomeDBiP81270.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: P81270-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ    50
TSKMSPRVPQ QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM 100
VGSPDTVGMS YGSYMEEKHV PPPNMTTNER RVIVPADPTL WSTDHVRQWL 150
EWAVKEYGLL DVDVLLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH 200
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR 250
ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY 300
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD 350
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH 400
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVSP HPPALPVTSS 450
SFFASPNPYW NSPTGGIYPN TRLPASHMPS HLGTYY 486
Length:486
Mass (Da):54,614
Last modified:June 20, 2003 - v2
Checksum:iBF1ADF00A4772F75
GO
Isoform 1 (identifier: P81270-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,037
Checksum:i0EA419B53ECA5591
GO
Isoform 2 (identifier: P81270-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.

Show »
Length:463
Mass (Da):51,971
Checksum:i510D2BB76663D4A4
GO
Isoform 5 (identifier: P81270-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,843
Checksum:iBAA90BE63412B968
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111MIQTVPDPAAH → MAST in isoform 5. VSP_026585Add
BLAST
Alternative sequencei232 – 25524Missing in isoform 1. VSP_007641Add
BLAST
Alternative sequencei256 – 27823Missing in isoform 2. VSP_007642Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751L → Q in BAC37131. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB073078 mRNA. Translation: BAB69948.1.
AB073079 mRNA. Translation: BAB69949.1.
AB073080 mRNA. Translation: BAB69950.1.
AK050922 mRNA. Translation: BAC34461.1.
AK078113 mRNA. Translation: BAC37131.1.
BC145850 mRNA. Translation: AAI45851.1.
S66169 mRNA. Translation: AAB28525.1.
CCDSiCCDS37411.1. [P81270-1]
PIRiA54617.
RefSeqiNP_598420.1. NM_133659.2. [P81270-1]
XP_006522957.1. XM_006522894.1. [P81270-1]
XP_006522958.1. XM_006522895.1. [P81270-1]
XP_006522959.1. XM_006522896.1. [P81270-1]
XP_006522962.1. XM_006522899.1. [P81270-2]
XP_006522963.1. XM_006522900.1. [P81270-3]
XP_006522964.1. XM_006522901.1. [P81270-3]
XP_006523225.1. XM_006523162.1. [P81270-1]
XP_006523226.1. XM_006523163.1. [P81270-1]
XP_006523227.1. XM_006523164.1. [P81270-1]
XP_006523230.1. XM_006523167.1. [P81270-2]
XP_006523231.1. XM_006523168.1. [P81270-3]
XP_006523232.1. XM_006523169.1. [P81270-3]
UniGeneiMm.164531.

Genome annotation databases

EnsembliENSMUST00000077773; ENSMUSP00000076949; ENSMUSG00000040732. [P81270-3]
ENSMUST00000113846; ENSMUSP00000109477; ENSMUSG00000040732. [P81270-1]
ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732. [P81270-2]
ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732. [P81270-4]
GeneIDi13876.
KEGGimmu:13876.
UCSCiuc008acb.1. mouse. [P81270-1]
uc008acc.1. mouse. [P81270-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB073078 mRNA. Translation: BAB69948.1 .
AB073079 mRNA. Translation: BAB69949.1 .
AB073080 mRNA. Translation: BAB69950.1 .
AK050922 mRNA. Translation: BAC34461.1 .
AK078113 mRNA. Translation: BAC37131.1 .
BC145850 mRNA. Translation: AAI45851.1 .
S66169 mRNA. Translation: AAB28525.1 .
CCDSi CCDS37411.1. [P81270-1 ]
PIRi A54617.
RefSeqi NP_598420.1. NM_133659.2. [P81270-1 ]
XP_006522957.1. XM_006522894.1. [P81270-1 ]
XP_006522958.1. XM_006522895.1. [P81270-1 ]
XP_006522959.1. XM_006522896.1. [P81270-1 ]
XP_006522962.1. XM_006522899.1. [P81270-2 ]
XP_006522963.1. XM_006522900.1. [P81270-3 ]
XP_006522964.1. XM_006522901.1. [P81270-3 ]
XP_006523225.1. XM_006523162.1. [P81270-1 ]
XP_006523226.1. XM_006523163.1. [P81270-1 ]
XP_006523227.1. XM_006523164.1. [P81270-1 ]
XP_006523230.1. XM_006523167.1. [P81270-2 ]
XP_006523231.1. XM_006523168.1. [P81270-3 ]
XP_006523232.1. XM_006523169.1. [P81270-3 ]
UniGenei Mm.164531.

3D structure databases

ProteinModelPortali P81270.
SMRi P81270. Positions 112-208, 307-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199504. 4 interactions.
IntActi P81270. 2 interactions.
MINTi MINT-4122342.

PTM databases

PhosphoSitei P81270.

Proteomic databases

MaxQBi P81270.
PaxDbi P81270.
PRIDEi P81270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077773 ; ENSMUSP00000076949 ; ENSMUSG00000040732 . [P81270-3 ]
ENSMUST00000113846 ; ENSMUSP00000109477 ; ENSMUSG00000040732 . [P81270-1 ]
ENSMUST00000113848 ; ENSMUSP00000109479 ; ENSMUSG00000040732 . [P81270-2 ]
ENSMUST00000122199 ; ENSMUSP00000114072 ; ENSMUSG00000040732 . [P81270-4 ]
GeneIDi 13876.
KEGGi mmu:13876.
UCSCi uc008acb.1. mouse. [P81270-1 ]
uc008acc.1. mouse. [P81270-2 ]

Organism-specific databases

CTDi 2078.
MGIi MGI:95415. Erg.

Phylogenomic databases

eggNOGi NOG242679.
GeneTreei ENSGT00740000115153.
HOGENOMi HOG000290658.
HOVERGENi HBG001553.
InParanoidi A6H6E7.
KOi K09435.
OMAi NSNCITW.
OrthoDBi EOG73V6K8.
PhylomeDBi P81270.
TreeFami TF350537.

Miscellaneous databases

NextBioi 284804.
PROi P81270.
SOURCEi Search...

Gene expression databases

ArrayExpressi P81270.
Bgeei P81270.
Genevestigatori P81270.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ozawa R., Noguchi H., Taylor T.D., Takeda T., Hattori M., Sakaki Y.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
    Strain: C57BL/6J.
    Tissue: Embryo and Medulla oblongata.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression."
    Rivera R.R., Stuiver M.H., Steenbergen R., Murre C.
    Mol. Cell. Biol. 13:7163-7169(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-452.
  5. "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor."
    Yang L., Xia L., Wu D.Y., Wang H., Chansky H.A., Schubach W.H., Hickstein D.D., Zhang Y.
    Oncogene 21:148-152(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SETDB1.

Entry informationi

Entry nameiERG_MOUSE
AccessioniPrimary (citable) accession number: P81270
Secondary accession number(s): A6H6E7
, Q8C5L4, Q920K7, Q920K8, Q920K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2003
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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