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Protein

Transcriptional regulator ERG

Gene

Erg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi318 – 398ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: MGI
  • endocardial cushion development Source: MGI
  • endocardial cushion to mesenchymal transition involved in heart valve formation Source: MGI
  • positive regulation of blood vessel remodeling Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ERG
Gene namesi
Name:Erg
Synonyms:Erg-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:95415. Erg.

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041041 – 486Transcriptional regulator ERGAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP81270.
PaxDbiP81270.
PRIDEiP81270.

PTM databases

iPTMnetiP81270.
PhosphoSitePlusiP81270.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040732.
ExpressionAtlasiP81270. baseline and differential.
GenevisibleiP81270. MM.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Setdb1O889743EBI-79647,EBI-79658

Protein-protein interaction databases

BioGridi199504. 5 interactors.
IntActiP81270. 2 interactors.
MINTiMINT-4122342.
STRINGi10090.ENSMUSP00000109477.

Structurei

3D structure databases

ProteinModelPortaliP81270.
SMRiP81270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 206PNTPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiP81270.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG091G0EWP.
PhylomeDBiP81270.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: P81270-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM
110 120 130 140 150
VGSPDTVGMS YGSYMEEKHV PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLL DVDVLLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVSP HPPALPVTSS
460 470 480
SFFASPNPYW NSPTGGIYPN TRLPASHMPS HLGTYY
Length:486
Mass (Da):54,614
Last modified:June 20, 2003 - v2
Checksum:iBF1ADF00A4772F75
GO
Isoform 1 (identifier: P81270-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,037
Checksum:i0EA419B53ECA5591
GO
Isoform 2 (identifier: P81270-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.

Show »
Length:463
Mass (Da):51,971
Checksum:i510D2BB76663D4A4
GO
Isoform 5 (identifier: P81270-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,843
Checksum:iBAA90BE63412B968
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175L → Q in BAC37131 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0265851 – 11MIQTVPDPAAH → MAST in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_007641232 – 255Missing in isoform 1. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_007642256 – 278Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073078 mRNA. Translation: BAB69948.1.
AB073079 mRNA. Translation: BAB69949.1.
AB073080 mRNA. Translation: BAB69950.1.
AK050922 mRNA. Translation: BAC34461.1.
AK078113 mRNA. Translation: BAC37131.1.
BC145850 mRNA. Translation: AAI45851.1.
S66169 mRNA. Translation: AAB28525.1.
CCDSiCCDS37411.1. [P81270-1]
CCDS79493.1. [P81270-4]
CCDS79495.1. [P81270-3]
CCDS79496.1. [P81270-2]
PIRiA54617.
RefSeqiNP_001289081.1. NM_001302152.1. [P81270-3]
NP_001289082.1. NM_001302153.1. [P81270-4]
NP_001289083.1. NM_001302154.1.
NP_001289108.1. NM_001302179.1. [P81270-2]
NP_001289112.1. NM_001302183.1.
NP_598420.1. NM_133659.3. [P81270-1]
XP_006522957.1. XM_006522894.3. [P81270-1]
XP_006522958.1. XM_006522895.2. [P81270-1]
XP_006522959.1. XM_006522896.3. [P81270-1]
XP_006522962.1. XM_006522899.3. [P81270-2]
XP_006522963.1. XM_006522900.2. [P81270-3]
UniGeneiMm.164531.

Genome annotation databases

EnsembliENSMUST00000077773; ENSMUSP00000076949; ENSMUSG00000040732. [P81270-3]
ENSMUST00000113846; ENSMUSP00000109477; ENSMUSG00000040732. [P81270-1]
ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732. [P81270-2]
ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732. [P81270-4]
GeneIDi13876.
KEGGimmu:13876.
UCSCiuc008acb.2. mouse. [P81270-1]
uc008acc.2. mouse. [P81270-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073078 mRNA. Translation: BAB69948.1.
AB073079 mRNA. Translation: BAB69949.1.
AB073080 mRNA. Translation: BAB69950.1.
AK050922 mRNA. Translation: BAC34461.1.
AK078113 mRNA. Translation: BAC37131.1.
BC145850 mRNA. Translation: AAI45851.1.
S66169 mRNA. Translation: AAB28525.1.
CCDSiCCDS37411.1. [P81270-1]
CCDS79493.1. [P81270-4]
CCDS79495.1. [P81270-3]
CCDS79496.1. [P81270-2]
PIRiA54617.
RefSeqiNP_001289081.1. NM_001302152.1. [P81270-3]
NP_001289082.1. NM_001302153.1. [P81270-4]
NP_001289083.1. NM_001302154.1.
NP_001289108.1. NM_001302179.1. [P81270-2]
NP_001289112.1. NM_001302183.1.
NP_598420.1. NM_133659.3. [P81270-1]
XP_006522957.1. XM_006522894.3. [P81270-1]
XP_006522958.1. XM_006522895.2. [P81270-1]
XP_006522959.1. XM_006522896.3. [P81270-1]
XP_006522962.1. XM_006522899.3. [P81270-2]
XP_006522963.1. XM_006522900.2. [P81270-3]
UniGeneiMm.164531.

3D structure databases

ProteinModelPortaliP81270.
SMRiP81270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199504. 5 interactors.
IntActiP81270. 2 interactors.
MINTiMINT-4122342.
STRINGi10090.ENSMUSP00000109477.

PTM databases

iPTMnetiP81270.
PhosphoSitePlusiP81270.

Proteomic databases

MaxQBiP81270.
PaxDbiP81270.
PRIDEiP81270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077773; ENSMUSP00000076949; ENSMUSG00000040732. [P81270-3]
ENSMUST00000113846; ENSMUSP00000109477; ENSMUSG00000040732. [P81270-1]
ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732. [P81270-2]
ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732. [P81270-4]
GeneIDi13876.
KEGGimmu:13876.
UCSCiuc008acb.2. mouse. [P81270-1]
uc008acc.2. mouse. [P81270-2]

Organism-specific databases

CTDi2078.
MGIiMGI:95415. Erg.

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiP81270.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG091G0EWP.
PhylomeDBiP81270.
TreeFamiTF350537.

Miscellaneous databases

PROiP81270.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040732.
ExpressionAtlasiP81270. baseline and differential.
GenevisibleiP81270. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERG_MOUSE
AccessioniPrimary (citable) accession number: P81270
Secondary accession number(s): A6H6E7
, Q8C5L4, Q920K7, Q920K8, Q920K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2003
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.