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P81270

- ERG_MOUSE

UniProt

P81270 - ERG_MOUSE

Protein

Transcriptional regulator ERG

Gene

Erg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi318 – 39881ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    3. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulator ERG
    Gene namesi
    Name:Erg
    Synonyms:Erg-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:95415. Erg.

    Subcellular locationi

    Nucleus. Cytoplasm By similarity
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: RefGenome
    3. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Transcriptional regulator ERGPRO_0000204104Add
    BLAST

    Proteomic databases

    MaxQBiP81270.
    PaxDbiP81270.
    PRIDEiP81270.

    PTM databases

    PhosphoSiteiP81270.

    Expressioni

    Gene expression databases

    ArrayExpressiP81270.
    BgeeiP81270.
    GenevestigatoriP81270.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Setdb1O889743EBI-79647,EBI-79658

    Protein-protein interaction databases

    BioGridi199504. 4 interactions.
    IntActiP81270. 2 interactions.
    MINTiMINT-4122342.

    Structurei

    3D structure databases

    ProteinModelPortaliP81270.
    SMRiP81270. Positions 112-208, 307-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini120 – 20687PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242679.
    GeneTreeiENSGT00740000115153.
    HOGENOMiHOG000290658.
    HOVERGENiHBG001553.
    InParanoidiA6H6E7.
    KOiK09435.
    OMAiNSNCITW.
    OrthoDBiEOG73V6K8.
    PhylomeDBiP81270.
    TreeFamiTF350537.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: P81270-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ    50
    TSKMSPRVPQ QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM 100
    VGSPDTVGMS YGSYMEEKHV PPPNMTTNER RVIVPADPTL WSTDHVRQWL 150
    EWAVKEYGLL DVDVLLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH 200
    YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR 250
    ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY 300
    QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD 350
    PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH 400
    GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVSP HPPALPVTSS 450
    SFFASPNPYW NSPTGGIYPN TRLPASHMPS HLGTYY 486
    Length:486
    Mass (Da):54,614
    Last modified:June 20, 2003 - v2
    Checksum:iBF1ADF00A4772F75
    GO
    Isoform 1 (identifier: P81270-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         232-255: Missing.

    Show »
    Length:462
    Mass (Da):52,037
    Checksum:i0EA419B53ECA5591
    GO
    Isoform 2 (identifier: P81270-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         256-278: Missing.

    Show »
    Length:463
    Mass (Da):51,971
    Checksum:i510D2BB76663D4A4
    GO
    Isoform 5 (identifier: P81270-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: MIQTVPDPAAH → MAST

    Show »
    Length:479
    Mass (Da):53,843
    Checksum:iBAA90BE63412B968
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751L → Q in BAC37131. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111MIQTVPDPAAH → MAST in isoform 5. 1 PublicationVSP_026585Add
    BLAST
    Alternative sequencei232 – 25524Missing in isoform 1. 2 PublicationsVSP_007641Add
    BLAST
    Alternative sequencei256 – 27823Missing in isoform 2. 2 PublicationsVSP_007642Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073078 mRNA. Translation: BAB69948.1.
    AB073079 mRNA. Translation: BAB69949.1.
    AB073080 mRNA. Translation: BAB69950.1.
    AK050922 mRNA. Translation: BAC34461.1.
    AK078113 mRNA. Translation: BAC37131.1.
    BC145850 mRNA. Translation: AAI45851.1.
    S66169 mRNA. Translation: AAB28525.1.
    CCDSiCCDS37411.1. [P81270-1]
    PIRiA54617.
    RefSeqiNP_598420.1. NM_133659.2. [P81270-1]
    XP_006522957.1. XM_006522894.1. [P81270-1]
    XP_006522958.1. XM_006522895.1. [P81270-1]
    XP_006522959.1. XM_006522896.1. [P81270-1]
    XP_006522962.1. XM_006522899.1. [P81270-2]
    XP_006522963.1. XM_006522900.1. [P81270-3]
    XP_006522964.1. XM_006522901.1. [P81270-3]
    XP_006523225.1. XM_006523162.1. [P81270-1]
    XP_006523226.1. XM_006523163.1. [P81270-1]
    XP_006523227.1. XM_006523164.1. [P81270-1]
    XP_006523230.1. XM_006523167.1. [P81270-2]
    XP_006523231.1. XM_006523168.1. [P81270-3]
    XP_006523232.1. XM_006523169.1. [P81270-3]
    UniGeneiMm.164531.

    Genome annotation databases

    EnsembliENSMUST00000077773; ENSMUSP00000076949; ENSMUSG00000040732. [P81270-3]
    ENSMUST00000113846; ENSMUSP00000109477; ENSMUSG00000040732. [P81270-1]
    ENSMUST00000113848; ENSMUSP00000109479; ENSMUSG00000040732. [P81270-2]
    ENSMUST00000122199; ENSMUSP00000114072; ENSMUSG00000040732. [P81270-4]
    GeneIDi13876.
    KEGGimmu:13876.
    UCSCiuc008acb.1. mouse. [P81270-1]
    uc008acc.1. mouse. [P81270-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073078 mRNA. Translation: BAB69948.1 .
    AB073079 mRNA. Translation: BAB69949.1 .
    AB073080 mRNA. Translation: BAB69950.1 .
    AK050922 mRNA. Translation: BAC34461.1 .
    AK078113 mRNA. Translation: BAC37131.1 .
    BC145850 mRNA. Translation: AAI45851.1 .
    S66169 mRNA. Translation: AAB28525.1 .
    CCDSi CCDS37411.1. [P81270-1 ]
    PIRi A54617.
    RefSeqi NP_598420.1. NM_133659.2. [P81270-1 ]
    XP_006522957.1. XM_006522894.1. [P81270-1 ]
    XP_006522958.1. XM_006522895.1. [P81270-1 ]
    XP_006522959.1. XM_006522896.1. [P81270-1 ]
    XP_006522962.1. XM_006522899.1. [P81270-2 ]
    XP_006522963.1. XM_006522900.1. [P81270-3 ]
    XP_006522964.1. XM_006522901.1. [P81270-3 ]
    XP_006523225.1. XM_006523162.1. [P81270-1 ]
    XP_006523226.1. XM_006523163.1. [P81270-1 ]
    XP_006523227.1. XM_006523164.1. [P81270-1 ]
    XP_006523230.1. XM_006523167.1. [P81270-2 ]
    XP_006523231.1. XM_006523168.1. [P81270-3 ]
    XP_006523232.1. XM_006523169.1. [P81270-3 ]
    UniGenei Mm.164531.

    3D structure databases

    ProteinModelPortali P81270.
    SMRi P81270. Positions 112-208, 307-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199504. 4 interactions.
    IntActi P81270. 2 interactions.
    MINTi MINT-4122342.

    PTM databases

    PhosphoSitei P81270.

    Proteomic databases

    MaxQBi P81270.
    PaxDbi P81270.
    PRIDEi P81270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077773 ; ENSMUSP00000076949 ; ENSMUSG00000040732 . [P81270-3 ]
    ENSMUST00000113846 ; ENSMUSP00000109477 ; ENSMUSG00000040732 . [P81270-1 ]
    ENSMUST00000113848 ; ENSMUSP00000109479 ; ENSMUSG00000040732 . [P81270-2 ]
    ENSMUST00000122199 ; ENSMUSP00000114072 ; ENSMUSG00000040732 . [P81270-4 ]
    GeneIDi 13876.
    KEGGi mmu:13876.
    UCSCi uc008acb.1. mouse. [P81270-1 ]
    uc008acc.1. mouse. [P81270-2 ]

    Organism-specific databases

    CTDi 2078.
    MGIi MGI:95415. Erg.

    Phylogenomic databases

    eggNOGi NOG242679.
    GeneTreei ENSGT00740000115153.
    HOGENOMi HOG000290658.
    HOVERGENi HBG001553.
    InParanoidi A6H6E7.
    KOi K09435.
    OMAi NSNCITW.
    OrthoDBi EOG73V6K8.
    PhylomeDBi P81270.
    TreeFami TF350537.

    Miscellaneous databases

    NextBioi 284804.
    PROi P81270.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P81270.
    Bgeei P81270.
    Genevestigatori P81270.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ozawa R., Noguchi H., Taylor T.D., Takeda T., Hattori M., Sakaki Y.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
      Strain: C57BL/6J.
      Tissue: Embryo and Medulla oblongata.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    4. "Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression."
      Rivera R.R., Stuiver M.H., Steenbergen R., Murre C.
      Mol. Cell. Biol. 13:7163-7169(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-452.
    5. "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor."
      Yang L., Xia L., Wu D.Y., Wang H., Chansky H.A., Schubach W.H., Hickstein D.D., Zhang Y.
      Oncogene 21:148-152(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SETDB1.

    Entry informationi

    Entry nameiERG_MOUSE
    AccessioniPrimary (citable) accession number: P81270
    Secondary accession number(s): A6H6E7
    , Q8C5L4, Q920K7, Q920K8, Q920K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3