Reviewed, UniProtKB/Swiss-Prot P81269 (ATF1_MOUSE)

Names and origin

Protein names

Recommended name:
    Cyclic AMP-dependent transcription factor ATF-1
      Short name=cAMP-dependent transcription factor ATF-1
Alternative name(s):
    Activating transcription factor 1
    TCR-ATF1

Gene names

Name:

Atf1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes By similarity.
Subunit structure	Binds DNA as a dimer By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain. Contains 1 KID (kinase-inducible) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcription factor complex Inferred from direct assay. Source: MGI
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Cyclic AMP-dependent transcription factor ATF-1		PRO_0000076576
Regions
	Domain	31 – 90	60	KID
	Domain	239 – 260	22	Leucine-zipper
	DNA binding	214 – 233	20	Basic motif
Amino acid modifications
	Modified residue	63	1	Phosphoserine; by CaMK1 By similarity
	Modified residue	196	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81269-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 9885265159D64A0C	FASTA	269	29,238
	10 20 30 40 50 60 MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS SQKAHGILAR 70 80 90 100 110 120 RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI YQTSSGQYIA IAPNGALQLA 130 140 150 160 170 180 SPSTDGVQAL QTLTMTNSSS TQQGTILQYA QTSDGQQILV PSNQVVVQTA SGDMQTYQIR 190 200 210 220 230 240 TTPSATSLPQ TVVMTSPVTL ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE 250 260 NRVAVLENQN KTLIEELKTL KDLYSHKSV

References

[1]	"Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif." Lee M.-R., Chung C.-S., Liou M.-L., Wu M., Li W.-F., Hsueh Y.-P., Lai M.-Z. J. Immunol. 148:1906-1912(1992) [PubMed: 1531847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63725 mRNA. Translation: AAA40395.1.
IPI	IPI00119123.
PIR	A46490.
RefSeq	NP_031523.3. XP_001479052.1.
UniGene	Mm.473546 Mm.676
3D structure databases
SMR	P81269. Positions 213-267.
ModBase	Search...
Protein-protein interaction databases
STRING	P81269.
PTM databases
PhosphoSite	P81269.
Proteomic databases
PRIDE	P81269.
Genome annotation databases
Ensembl	ENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027; Mus musculus. [Genome view]
GeneID	100047421. 11908.
KEGG	mmu:100047421. mmu:11908.
UCSC	uc007xqs.1. mouse.
Organism-specific databases
CTD	11908.
MGI	MGI:1298366. Atf1.
Phylogenomic databases
eggNOG	roNOG10978.
HOGENOM	HBG446032.
HOVERGEN	P81269.
InParanoid	P81269.
OMA	EDSHKST.
OrthoDB	EOG9FN73R.
PhylomeDB	P81269.
Gene expression databases
ArrayExpress	P81269.
Bgee	P81269.
CleanEx	MM_ATF1.
Genevestigator	P81269.
GermOnline	ENSMUSG00000023027. Mus musculus.
Family and domain databases
InterPro	IPR011616. bZIP_1. IPR003102. Coactivator_CBP_pKID. IPR001630. Leuzip_CREB. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. PF02173. pKID. 1 hit. [Graphical view]
PRINTS	PR00041. LEUZIPPRCREB.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. PS50953. KID. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	460856.
SOURCE	Search...

Entry information

Entry name

ATF1_MOUSE

Accession

Primary (citable) accession number: P81269

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	January 19, 2010
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)