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P81269

- ATF1_MOUSE

UniProt

P81269 - ATF1_MOUSE

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Protein

Cyclic AMP-dependent transcription factor ATF-1

Gene
Atf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation By similarity.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. cellular protein complex assembly Source: Ensembl
  2. positive regulation of DNA replication Source: Ensembl
  3. positive regulation of neuron projection development Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. response to cobalt ion Source: Ensembl
  6. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_224314. CREB phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-1
Short name:
cAMP-dependent transcription factor ATF-1
Alternative name(s):
Activating transcription factor 1
TCR-ATF1
Gene namesi
Name:Atf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1298366. Atf1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cyclic AMP-dependent transcription factor ATF-1PRO_0000076576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA5 Inferred
Modified residuei196 – 1961Phosphoserine; by HIPK2 By similarity

Post-translational modificationi

Phosphorylated at Ser-196 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities By similarity. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP81269.
PRIDEiP81269.

PTM databases

PhosphoSiteiP81269.

Expressioni

Gene expression databases

ArrayExpressiP81269.
BgeeiP81269.
CleanExiMM_ATF1.
GenevestigatoriP81269.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with HIPK2 and CDK3 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP81269.
SMRiP81269. Positions 213-267.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9060KIDAdd
BLAST
Domaini211 – 26959bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 23725Basic motif By similarityAdd
BLAST
Regioni239 – 26022Leucine-zipper By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.

Phylogenomic databases

eggNOGiNOG255464.
GeneTreeiENSGT00390000008655.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiP81269.
KOiK09053.
OMAiHIAQQMS.
OrthoDBiEOG72G18D.
PhylomeDBiP81269.
TreeFamiTF106464.

Family and domain databases

InterProiIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81269-1 [UniParc]FASTAAdd to Basket

« Hide

MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS    50
SQKAHGILAR RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI 100
YQTSSGQYIA IAPNGALQLA SPSTDGVQAL QTLTMTNSSS TQQGTILQYA 150
QTSDGQQILV PSNQVVVQTA SGDMQTYQIR TTPSATSLPQ TVVMTSPVTL 200
ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE NRVAVLENQN 250
KTLIEELKTL KDLYSHKSV 269
Length:269
Mass (Da):29,238
Last modified:July 15, 1998 - v1
Checksum:i9885265159D64A0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63725 mRNA. Translation: AAA40395.1.
CCDSiCCDS27832.1.
PIRiA46490.
RefSeqiNP_031523.3. NM_007497.3.
XP_006520414.1. XM_006520351.1.
XP_006520415.1. XM_006520352.1.
UniGeneiMm.676.

Genome annotation databases

EnsembliENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027.
GeneIDi11908.
KEGGimmu:11908.
UCSCiuc007xqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63725 mRNA. Translation: AAA40395.1 .
CCDSi CCDS27832.1.
PIRi A46490.
RefSeqi NP_031523.3. NM_007497.3.
XP_006520414.1. XM_006520351.1.
XP_006520415.1. XM_006520352.1.
UniGenei Mm.676.

3D structure databases

ProteinModelPortali P81269.
SMRi P81269. Positions 213-267.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P81269.

Proteomic databases

PaxDbi P81269.
PRIDEi P81269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023769 ; ENSMUSP00000023769 ; ENSMUSG00000023027 .
GeneIDi 11908.
KEGGi mmu:11908.
UCSCi uc007xqs.1. mouse.

Organism-specific databases

CTDi 466.
MGIi MGI:1298366. Atf1.

Phylogenomic databases

eggNOGi NOG255464.
GeneTreei ENSGT00390000008655.
HOGENOMi HOG000007365.
HOVERGENi HBG011077.
InParanoidi P81269.
KOi K09053.
OMAi HIAQQMS.
OrthoDBi EOG72G18D.
PhylomeDBi P81269.
TreeFami TF106464.

Enzyme and pathway databases

Reactomei REACT_224314. CREB phosphorylation.

Miscellaneous databases

NextBioi 279967.
PROi P81269.
SOURCEi Search...

Gene expression databases

ArrayExpressi P81269.
Bgeei P81269.
CleanExi MM_ATF1.
Genevestigatori P81269.

Family and domain databases

InterProi IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif."
    Lee M.-R., Chung C.-S., Liou M.-L., Wu M., Li W.-F., Hsueh Y.-P., Lai M.-Z.
    J. Immunol. 148:1906-1912(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling."
    Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J., Park J.M., Wingate A., Monk C.E., Toth R., Santos S.G., Iversen L., Arthur J.S.
    Nat. Immunol. 9:1028-1036(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-63.

Entry informationi

Entry nameiATF1_MOUSE
AccessioniPrimary (citable) accession number: P81269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi