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Protein

Cyclic AMP-dependent transcription factor ATF-1

Gene

Atf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI

GO - Biological processi

  1. cellular protein complex assembly Source: Ensembl
  2. positive regulation of DNA replication Source: Ensembl
  3. positive regulation of neuron projection development Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. response to cobalt ion Source: Ensembl
  6. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_277525. CREB phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-1
Short name:
cAMP-dependent transcription factor ATF-1
Alternative name(s):
Activating transcription factor 1
TCR-ATF1
Gene namesi
Name:Atf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1298366. Atf1.

Subcellular locationi

GO - Cellular componenti

  1. ATF1-ATF4 transcription factor complex Source: ParkinsonsUK-UCL
  2. nucleoplasm Source: MGI
  3. nucleus Source: MGI
  4. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cyclic AMP-dependent transcription factor ATF-1PRO_0000076576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA51 Publication
Modified residuei196 – 1961Phosphoserine; by HIPK2PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated at Ser-196 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities (By similarity). Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP81269.
PaxDbiP81269.
PRIDEiP81269.

PTM databases

PhosphoSiteiP81269.

Expressioni

Gene expression databases

BgeeiP81269.
CleanExiMM_ATF1.
ExpressionAtlasiP81269. baseline and differential.
GenevestigatoriP81269.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with HIPK2 and CDK3 (By similarity).By similarity

Protein-protein interaction databases

IntActiP81269. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP81269.
SMRiP81269. Positions 213-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9060KIDPROSITE-ProRule annotationAdd
BLAST
Domaini211 – 26959bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 23725Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni239 – 26022Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG255464.
GeneTreeiENSGT00390000008655.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiP81269.
KOiK09053.
OMAiHIAQQMS.
OrthoDBiEOG72G18D.
PhylomeDBiP81269.
TreeFamiTF106464.

Family and domain databases

InterProiIPR029825. ATF1.
IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PANTHERiPTHR22952:SF99. PTHR22952:SF99. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS
60 70 80 90 100
SQKAHGILAR RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI
110 120 130 140 150
YQTSSGQYIA IAPNGALQLA SPSTDGVQAL QTLTMTNSSS TQQGTILQYA
160 170 180 190 200
QTSDGQQILV PSNQVVVQTA SGDMQTYQIR TTPSATSLPQ TVVMTSPVTL
210 220 230 240 250
ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE NRVAVLENQN
260
KTLIEELKTL KDLYSHKSV
Length:269
Mass (Da):29,238
Last modified:July 15, 1998 - v1
Checksum:i9885265159D64A0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63725 mRNA. Translation: AAA40395.1.
CCDSiCCDS27832.1.
PIRiA46490.
RefSeqiNP_031523.3. NM_007497.3.
XP_006520414.1. XM_006520351.2.
XP_006520415.1. XM_006520352.2.
UniGeneiMm.676.

Genome annotation databases

EnsembliENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027.
GeneIDi11908.
KEGGimmu:11908.
UCSCiuc007xqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63725 mRNA. Translation: AAA40395.1.
CCDSiCCDS27832.1.
PIRiA46490.
RefSeqiNP_031523.3. NM_007497.3.
XP_006520414.1. XM_006520351.2.
XP_006520415.1. XM_006520352.2.
UniGeneiMm.676.

3D structure databases

ProteinModelPortaliP81269.
SMRiP81269. Positions 213-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP81269. 1 interaction.

PTM databases

PhosphoSiteiP81269.

Proteomic databases

MaxQBiP81269.
PaxDbiP81269.
PRIDEiP81269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027.
GeneIDi11908.
KEGGimmu:11908.
UCSCiuc007xqs.1. mouse.

Organism-specific databases

CTDi466.
MGIiMGI:1298366. Atf1.

Phylogenomic databases

eggNOGiNOG255464.
GeneTreeiENSGT00390000008655.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiP81269.
KOiK09053.
OMAiHIAQQMS.
OrthoDBiEOG72G18D.
PhylomeDBiP81269.
TreeFamiTF106464.

Enzyme and pathway databases

ReactomeiREACT_277525. CREB phosphorylation.

Miscellaneous databases

NextBioi279967.
PROiP81269.
SOURCEiSearch...

Gene expression databases

BgeeiP81269.
CleanExiMM_ATF1.
ExpressionAtlasiP81269. baseline and differential.
GenevestigatoriP81269.

Family and domain databases

InterProiIPR029825. ATF1.
IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PANTHERiPTHR22952:SF99. PTHR22952:SF99. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif."
    Lee M.-R., Chung C.-S., Liou M.-L., Wu M., Li W.-F., Hsueh Y.-P., Lai M.-Z.
    J. Immunol. 148:1906-1912(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling."
    Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J., Park J.M., Wingate A., Monk C.E., Toth R., Santos S.G., Iversen L., Arthur J.S.
    Nat. Immunol. 9:1028-1036(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-63.

Entry informationi

Entry nameiATF1_MOUSE
AccessioniPrimary (citable) accession number: P81269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 1, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.