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P81269 (ATF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclic AMP-dependent transcription factor ATF-1

Short name=cAMP-dependent transcription factor ATF-1
Alternative name(s):
Activating transcription factor 1
TCR-ATF1
Gene names
Name:Atf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation By similarity.

Subunit structure

Binds DNA as a dimer. Interacts with HIPK2 and CDK3 By similarity.

Subcellular location

Nucleus.

Post-translational modification

Phosphorylated at Ser-196 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities By similarity. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Ref.2

Sequence similarities

Belongs to the bZIP family. ATF subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Contains 1 KID (kinase-inducible) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Cyclic AMP-dependent transcription factor ATF-1
PRO_0000076576

Regions

Domain31 – 9060KID
Domain211 – 26959bZIP
Region213 – 23725Basic motif By similarity
Region239 – 26022Leucine-zipper By similarity

Amino acid modifications

Modified residue631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA5 Probable
Modified residue1961Phosphoserine; by HIPK2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P81269 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 9885265159D64A0C

FASTA26929,238
        10         20         30         40         50         60 
MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS SQKAHGILAR 

        70         80         90        100        110        120 
RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI YQTSSGQYIA IAPNGALQLA 

       130        140        150        160        170        180 
SPSTDGVQAL QTLTMTNSSS TQQGTILQYA QTSDGQQILV PSNQVVVQTA SGDMQTYQIR 

       190        200        210        220        230        240 
TTPSATSLPQ TVVMTSPVTL ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE 

       250        260 
NRVAVLENQN KTLIEELKTL KDLYSHKSV 

« Hide

References

[1]"Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif."
Lee M.-R., Chung C.-S., Liou M.-L., Wu M., Li W.-F., Hsueh Y.-P., Lai M.-Z.
J. Immunol. 148:1906-1912(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling."
Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J., Park J.M., Wingate A., Monk C.E., Toth R., Santos S.G., Iversen L., Arthur J.S.
Nat. Immunol. 9:1028-1036(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-63.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63725 mRNA. Translation: AAA40395.1.
CCDSCCDS27832.1.
PIRA46490.
RefSeqNP_031523.3. NM_007497.3.
XP_006520414.1. XM_006520351.1.
XP_006520415.1. XM_006520352.1.
UniGeneMm.676.

3D structure databases

ProteinModelPortalP81269.
SMRP81269. Positions 213-267.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP81269.

Proteomic databases

PaxDbP81269.
PRIDEP81269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027.
GeneID11908.
KEGGmmu:11908.
UCSCuc007xqs.1. mouse.

Organism-specific databases

CTD466.
MGIMGI:1298366. Atf1.

Phylogenomic databases

eggNOGNOG255464.
GeneTreeENSGT00390000008655.
HOGENOMHOG000007365.
HOVERGENHBG011077.
InParanoidP81269.
KOK09053.
OMAHIAQQMS.
OrthoDBEOG72G18D.
PhylomeDBP81269.
TreeFamTF106464.

Gene expression databases

ArrayExpressP81269.
BgeeP81269.
CleanExMM_ATF1.
GenevestigatorP81269.

Family and domain databases

InterProIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSPR00041. LEUZIPPRCREB.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279967.
PROP81269.
SOURCESearch...

Entry information

Entry nameATF1_MOUSE
AccessionPrimary (citable) accession number: P81269
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot