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P81269

- ATF1_MOUSE

UniProt

P81269 - ATF1_MOUSE

Protein

Cyclic AMP-dependent transcription factor ATF-1

Gene

Atf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. cellular protein complex assembly Source: Ensembl
    2. positive regulation of DNA replication Source: Ensembl
    3. positive regulation of neuron projection development Source: Ensembl
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. response to cobalt ion Source: Ensembl
    6. response to organic cyclic compound Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_224314. CREB phosphorylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-1
    Short name:
    cAMP-dependent transcription factor ATF-1
    Alternative name(s):
    Activating transcription factor 1
    TCR-ATF1
    Gene namesi
    Name:Atf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1298366. Atf1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Cyclic AMP-dependent transcription factor ATF-1PRO_0000076576Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA51 Publication
    Modified residuei196 – 1961Phosphoserine; by HIPK2PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated at Ser-196 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities By similarity. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP81269.
    PRIDEiP81269.

    PTM databases

    PhosphoSiteiP81269.

    Expressioni

    Gene expression databases

    ArrayExpressiP81269.
    BgeeiP81269.
    CleanExiMM_ATF1.
    GenevestigatoriP81269.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Interacts with HIPK2 and CDK3 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP81269.
    SMRiP81269. Positions 213-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 9060KIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini211 – 26959bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni213 – 23725Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni239 – 26022Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
    Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG255464.
    GeneTreeiENSGT00390000008655.
    HOGENOMiHOG000007365.
    HOVERGENiHBG011077.
    InParanoidiP81269.
    KOiK09053.
    OMAiHIAQQMS.
    OrthoDBiEOG72G18D.
    PhylomeDBiP81269.
    TreeFamiTF106464.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view]
    PRINTSiPR00041. LEUZIPPRCREB.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P81269-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS    50
    SQKAHGILAR RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI 100
    YQTSSGQYIA IAPNGALQLA SPSTDGVQAL QTLTMTNSSS TQQGTILQYA 150
    QTSDGQQILV PSNQVVVQTA SGDMQTYQIR TTPSATSLPQ TVVMTSPVTL 200
    ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE NRVAVLENQN 250
    KTLIEELKTL KDLYSHKSV 269
    Length:269
    Mass (Da):29,238
    Last modified:July 15, 1998 - v1
    Checksum:i9885265159D64A0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63725 mRNA. Translation: AAA40395.1.
    CCDSiCCDS27832.1.
    PIRiA46490.
    RefSeqiNP_031523.3. NM_007497.3.
    XP_006520414.1. XM_006520351.1.
    XP_006520415.1. XM_006520352.1.
    UniGeneiMm.676.

    Genome annotation databases

    EnsembliENSMUST00000023769; ENSMUSP00000023769; ENSMUSG00000023027.
    GeneIDi11908.
    KEGGimmu:11908.
    UCSCiuc007xqs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63725 mRNA. Translation: AAA40395.1 .
    CCDSi CCDS27832.1.
    PIRi A46490.
    RefSeqi NP_031523.3. NM_007497.3.
    XP_006520414.1. XM_006520351.1.
    XP_006520415.1. XM_006520352.1.
    UniGenei Mm.676.

    3D structure databases

    ProteinModelPortali P81269.
    SMRi P81269. Positions 213-267.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P81269.

    Proteomic databases

    PaxDbi P81269.
    PRIDEi P81269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023769 ; ENSMUSP00000023769 ; ENSMUSG00000023027 .
    GeneIDi 11908.
    KEGGi mmu:11908.
    UCSCi uc007xqs.1. mouse.

    Organism-specific databases

    CTDi 466.
    MGIi MGI:1298366. Atf1.

    Phylogenomic databases

    eggNOGi NOG255464.
    GeneTreei ENSGT00390000008655.
    HOGENOMi HOG000007365.
    HOVERGENi HBG011077.
    InParanoidi P81269.
    KOi K09053.
    OMAi HIAQQMS.
    OrthoDBi EOG72G18D.
    PhylomeDBi P81269.
    TreeFami TF106464.

    Enzyme and pathway databases

    Reactomei REACT_224314. CREB phosphorylation.

    Miscellaneous databases

    NextBioi 279967.
    PROi P81269.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P81269.
    Bgeei P81269.
    CleanExi MM_ATF1.
    Genevestigatori P81269.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view ]
    PRINTSi PR00041. LEUZIPPRCREB.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif."
      Lee M.-R., Chung C.-S., Liou M.-L., Wu M., Li W.-F., Hsueh Y.-P., Lai M.-Z.
      J. Immunol. 148:1906-1912(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling."
      Ananieva O., Darragh J., Johansen C., Carr J.M., McIlrath J., Park J.M., Wingate A., Monk C.E., Toth R., Santos S.G., Iversen L., Arthur J.S.
      Nat. Immunol. 9:1028-1036(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-63.

    Entry informationi

    Entry nameiATF1_MOUSE
    AccessioniPrimary (citable) accession number: P81269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3