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Protein

Interferon alpha-1/2

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1/2
Short name:
IFN-alpha-1/2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 187164Interferon alpha-1/2PRO_0000016392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 160By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP81255.
SMRiP81255. Positions 24-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000230500.
HOVERGENiHBG052086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPCSFSVA LVLLSCHSLC CLACHLPDTH GLRNWRVLTL LGQMRRLSAG
60 70 80 90 100
SCDHYTNDFA FPKELFDGQR LQEAQALSVV HVMTQKVFHL FCPDTSSAPW
110 120 130 140 150
NMTLLEELCS GLSEQLDDLE ACPLQEAGLA ETPLMHEDST LRTYFQRISL
160 170 180
YLQDRNHSPC AWEMVRAEIG RSFFSSTILQ ERIRRRK
Length:187
Mass (Da):21,320
Last modified:November 1, 1998 - v1
Checksum:i3B37BA87CA47C94B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28625 Genomic DNA. Translation: AAA30851.1.
M28624 Genomic DNA. Translation: AAA30850.1.
PIRiI46204.
RefSeqiXP_003431605.1. XM_003431557.2.
XP_003431691.1. XM_003431643.2.
XP_003431693.1. XM_003431645.2.
UniGeneiCfa.4550.

Genome annotation databases

GeneIDi100685213.
100687928.
100688084.
KEGGicfa:100685213.
cfa:100687928.
cfa:100688084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28625 Genomic DNA. Translation: AAA30851.1.
M28624 Genomic DNA. Translation: AAA30850.1.
PIRiI46204.
RefSeqiXP_003431605.1. XM_003431557.2.
XP_003431691.1. XM_003431643.2.
XP_003431693.1. XM_003431645.2.
UniGeneiCfa.4550.

3D structure databases

ProteinModelPortaliP81255.
SMRiP81255. Positions 24-187.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100685213.
100687928.
100688084.
KEGGicfa:100685213.
cfa:100687928.
cfa:100688084.

Phylogenomic databases

HOGENOMiHOG000230500.
HOVERGENiHBG052086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression in Escherichia coli of canine interferon-alpha genes."
    Himmler A., Hauptmann R., Adolf G.R., Swetly P.
    J. Interferon Res. 7:173-183(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiIFNA1_CANLF
AccessioniPrimary (citable) accession number: P81255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.