P81251 (CR18_LITCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Caerin-1.8
Organism	Litoria chloris (Blue-thighed frog)
Taxonomic identifier	86064 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Hyloidea › Hylidae › Pelodryadinae › Litoria

Protein attributes

Sequence length	24 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin dorsal glands.
Domain	Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility By similarity.
Sequence similarities	Belongs to the frog skin active peptide (FSAP) family. Caerin subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 24	24	Caerin-1.8		PRO_0000043739
Amino acid modifications
	Modified residue	24	1	Lysine amide

Sequences

	Sequence		Length	Mass (Da)
	P81251 [UniParc]. Last modified December 15, 1998. Version 1. Checksum: A77460A7EFDFEDAC	FASTA	24	2,552
	10 20 GLFKVLGSVA KHLLPHVVPV IAEK

References

[1]

"New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria." Steinborner S.T., Currie G.J., Bowie J.H., Wallace J.C., Tyler M.J. J. Pept. Res. 51:121-126(1998) [PubMed: 9516047] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010000. Caerin_1. [Graphical view]
Pfam	PF07440. Caerin_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CR18_LITCH

Accession

Primary (citable) accession number: P81251

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	March 2, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program