P81246 (PDIA3_PAPHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein disulfide-isomerase A3
EC=5.3.4.1

Alternative name(s):
58 kDa glucose-regulated protein
58 kDa microsomal protein
Short name=p58

Gene names

Name:	PDIA3
Synonyms:	GRP58

Organism

Papio hamadryas (Hamadryas baboon)

Taxonomic identifier

9557 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	39 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Catalyzes the rearrangement of -S-S- bonds in proteins.
Subunit structure	Interacts with ERP27 and CANX By similarity.
Subcellular location	Endoplasmic reticulum lumen. Melanosome By similarity.
Tissue specificity	Predominantly expressed in liver. Low in brain, testis and colon. Not detectable in pancreas and skeletal muscle.
Sequence similarities	Belongs to the protein disulfide isomerase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center
Molecular function	Isomerase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›39	›39	Protein disulfide-isomerase A3		PRO_0000120176
Experimental info
	Non-adjacent residues	22 – 23	2
	Non-adjacent residues	29 – 30	2
	Non-terminal residue	39	1

Sequences

	Sequence		Length	Mass (Da)
	P81246 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 4BDFEA7932B563CC	FASTA	39	4,086
	10 20 30 SDVLELTDDN FESRVSDTGS AGLVEFFAPD ATANDVPSP

References

[1]	"Purification of a 58-kDa protein (ER58) from monkey liver microsomes and comparison with protein-disulfide isomerase." Bonfils C. Eur. J. Biochem. 254:420-427(1998) [PubMed: 9660200] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Hepatocyte.

Cross-references

3D structure databases
ProteinModelPortal	P81246.
SMR	P81246. Positions 1-29.
ModBase	Search...
Proteomic databases
PRIDE	P81246.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDIA3_PAPHA

Accession

Primary (citable) accession number: P81246

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	July 27, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program