Reviewed, UniProtKB/Swiss-Prot P81246 (PDIA3_PAPHA)

Names and origin

Protein names

Recommended name:
    Protein disulfide-isomerase A3
    EC=5.3.4.1
Alternative name(s):
    58 kDa microsomal protein
    ER58

Gene names

Name:	PDIA3
Synonyms:	GRP58

Organism

Papio hamadryas (Hamadryas baboon)

Taxonomic identifier

9557 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	39 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Catalyzes the rearrangement of -S-S- bonds in proteins.
Subunit structure	Interacts with ERP27 and CANX By similarity.
Subcellular location	Endoplasmic reticulum lumen. Melanosome By similarity.
Tissue specificity	Predominantly expressed in liver. Low in brain, testis and colon. Not detectable in pancreas and skeletal muscle.
Sequence similarities	Belongs to the protein disulfide isomerase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Redox-active center
Molecular function	Isomerase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›39	›39	Protein disulfide-isomerase A3		PRO_0000120176
Experimental info
	Non-adjacent residues	22 – 23	2
	Non-adjacent residues	29 – 30	2
	Non-terminal residue	39	1

Sequences

	Sequence		Length	Mass (Da)
	P81246-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 4BDFEA7932B563CC	FASTA	39	4,086
	10 20 30 SDVLELTDDN FESRVSDTGS AGLVEFFAPD ATANDVPSP

References

[1]	"Purification of a 58-kDa protein (ER58) from monkey liver microsomes and comparison with protein-disulfide isomerase." Bonfils C. Eur. J. Biochem. 254:420-427(1998) [PubMed: 9660200] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Hepatocyte.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P81246.
Enzyme and pathway databases
BRENDA	5.3.4.1. 39388.
Family and domain databases
InterPro	IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view]
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDIA3_PAPHA

Accession

Primary (citable) accession number: P81246

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	September 22, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)