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Reviewed, UniProtKB/Swiss-Prot P81246 (PDIA3_PAPHA)

Last modified September 22, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein disulfide-isomerase A3
    EC=5.3.4.1
Alternative name(s):
    58 kDa microsomal protein
    ER58
Gene names
Name: PDIA3
Synonyms: GRP58
OrganismPapio hamadryas (Hamadryas baboon)
Taxonomic identifier9557 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Protein attributes

Sequence length39 AA.
Sequence statusFragments.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subunit structure

Interacts with ERP27 and CANX By similarity.

Subcellular location

Endoplasmic reticulum lumen. Melanosome By similarity.

Tissue specificity

Predominantly expressed in liver. Low in brain, testis and colon. Not detectable in pancreas and skeletal muscle.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRedox-active center
   Molecular functionIsomerase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

melanosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein disulfide isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›39›39Protein disulfide-isomerase A3
PRO_0000120176

Experimental info

Non-adjacent residues22 – 232
Non-adjacent residues29 – 302
Non-terminal residue391

Sequences

Sequence LengthMass (Da)Tools
P81246-1 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: 4BDFEA7932B563CC

FASTA394,086
        10         20         30 
SDVLELTDDN FESRVSDTGS AGLVEFFAPD ATANDVPSP 

« Hide

References

[1]"Purification of a 58-kDa protein (ER58) from monkey liver microsomes and comparison with protein-disulfide isomerase."
Bonfils C.
Eur. J. Biochem. 254:420-427(1998) [PubMed: 9660200] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Hepatocyte.

Cross-references

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENP81246.

Enzyme and pathway databases

BRENDA5.3.4.1. 39388.

Family and domain databases

InterProIPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
PROSITEPS00194. THIOREDOXIN_1. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDIA3_PAPHA
AccessionPrimary (citable) accession number: P81246
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 22, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents