Reviewed, UniProtKB/Swiss-Prot P81241 (CHLY_CARPA)

Names and origin

Protein names	Recommended name:     Bifunctional chitinase/lysozyme Including the following 2 domains:     1- Recommended name:             Chitinase               EC=3.2.1.14     2- Recommended name:             Lysozyme               EC=3.2.1.17
Organism	Carica papaya (Papaya)
Taxonomic identifier	3649 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Caricaceae › Carica

Protein attributes

Sequence length	25 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Bifunctional enzyme with lysozyme/chitinase activity.
Catalytic activity	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation
Cellular component	Secreted
Molecular function	Glycosidase Hydrolase
Technical term	Direct protein sequencing Multifunctional enzyme
Gene Ontology (GO)
Biological process	cell wall catabolic process Inferred from electronic annotation. Source: InterPro chitin catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chitinase activity Inferred from electronic annotation. Source: InterPro lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›25	›25	Bifunctional chitinase/lysozyme		PRO_0000124810
Experimental info
	Sequence conflict	3	1	E → S AA sequence Ref.2
	Non-adjacent residues	22 – 23	2
	Non-terminal residue	25	1

Sequences

	Sequence		Length	Mass (Da)
	P81241-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 33BA3F018F33ACD6	FASTA	25	2,877
	10 20 GIEKIISRSM FDQMLKHRNN PASFG

References

[1]	"Papaya (Carica papaya) lysozyme is a member of the family 19 (basic, class II) chitinases." Subroto T., Sufiati S., Beintema J.J. J. Mol. Evol. 49:819-821(1999) [PubMed: 10594185] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-22. Tissue: Latex.
[2]	"Papaya lysozyme. Terminal sequences and enzymatic properties." Howard J.B., Glazer A.N. J. Biol. Chem. 244:1399-1409(1969) [PubMed: 5773045] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-5 AND 23-25. Tissue: Latex.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR000726. Glyco_hydro_19_cat. [Graphical view]
Pfam	PF00182. Glyco_hydro_19. 1 hit. [Graphical view]
PROSITE	PS00773. CHITINASE_19_1. Partial match. PS00774. CHITINASE_19_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHLY_CARPA

Accession

Primary (citable) accession number: P81241

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 25, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)