P81241 (CHLY_CARPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Bifunctional chitinase/lysozyme Including the following 2 domains: Chitinase EC=3.2.1.14 Lysozyme EC=3.2.1.17
Organism	Carica papaya (Papaya)
Taxonomic identifier	3649 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Caricaceae › Carica

Protein attributes

Sequence length	25 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Bifunctional enzyme with lysozyme/chitinase activity.
Catalytic activity	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation
Cellular component	Secreted
Molecular function	Glycosidase Hydrolase
Technical term	Direct protein sequencing Multifunctional enzyme
Gene Ontology (GO)
Biological_process	chitin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW polysaccharide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chitinase activity Inferred from electronic annotation. Source: EC lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›25	›25	Bifunctional chitinase/lysozyme		PRO_0000124810
Experimental info
	Sequence conflict	3	1	E → S AA sequence Ref.2
	Non-adjacent residues	22 – 23	2
	Non-terminal residue	25	1

Sequences

	Sequence		Length	Mass (Da)
	P81241 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 33BA3F018F33ACD6	FASTA	25	2,877
	10 20 GIEKIISRSM FDQMLKHRNN PASFG

References

[1]	"Papaya (Carica papaya) lysozyme is a member of the family 19 (basic, class II) chitinases." Subroto T., Sufiati S., Beintema J.J. J. Mol. Evol. 49:819-821(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-22. Tissue: Latex.
[2]	"Papaya lysozyme. Terminal sequences and enzymatic properties." Howard J.B., Glazer A.N. J. Biol. Chem. 244:1399-1409(1969) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-5 AND 23-25. Tissue: Latex.

Cross-references

3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	1272. Car p Chitinase.
CAZy	GH19. Glycoside Hydrolase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00773. CHITINASE_19_1. Partial match. PS00774. CHITINASE_19_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHLY_CARPA

Accession

Primary (citable) accession number: P81241

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program