P81216 (ALL21_HORSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Dander allergen Equ c 2.0101 Alternative name(s): Allergen=Equ c 2.0101
Organism	Equus caballus (Horse) [Reference proteome]
Taxonomic identifier	9796 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	29 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Allergenic properties	Causes an allergic reaction in human. Potent allergen of horse dander. Ref.1
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.
Caution	Equ c 2.0101 and c 2.0102 might be two variants of the same protein.
Mass spectrometry	Molecular mass is 16000 Da from positions 1 - ?. Determined by ESI. Ref.2

Ontologies

Keywords
Biological process	Transport
Cellular component	Secreted
Disease	Allergen
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›29	›29	Dander allergen Equ c 2.0101		PRO_0000201032
Experimental info
	Non-terminal residue	29	1

Sequences

	Sequence		Length	Mass (Da)
	P81216 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: 4BBE0D9FF17A4EC6	FASTA	29	3,198
	10 20 SQXPQSETDY SQLSGEWNTI YGAASNIXK

References

[1]	"Separation of horse dander allergen proteins by two-dimensional electrophoresis -- molecular characterisation and identification of Equ c 2.0101 and Equ c 2.0102 as lipocalin proteins." Bulone V., Krogstad-Johnsen T., Smestad-Paulsen B. Eur. J. Biochem. 253:202-211(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, ALLERGEN. Tissue: Skin.
[2]	"Biochemical characterization and surfactant properties of horse allergens." Goubran Botros H., Poncet P., Rabillon J., Fontaine T., Laval J.-M., David B. Eur. J. Biochem. 268:3126-3136(2001) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY. Tissue: Dander.

Cross-references

3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	332. Equ c 2. 333. Equ c 2.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. [Graphical view]
PROSITE	PS00213. LIPOCALIN. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALL21_HORSE

Accession

Primary (citable) accession number: P81216

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program