Reviewed, UniProtKB/Swiss-Prot P81192 (HXA4_LINSA)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A4
Alternative name(s):
    LsHox 4

Gene names

Name:

HOXA4

Organism

Lineus sanguineus (Ribbon worm)

Taxonomic identifier

48190 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nemertea › Anopla › Heteronemertea › Lineidae › Lineus

Protein attributes

Sequence length	80 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Deformed subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›80	›80	Homeobox protein Hox-A4		PRO_0000200056
Regions
	DNA binding	21 – 80	60	Homeobox
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	80	1

Sequences

	Sequence		Length	Mass (Da)
	P81192-1 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: F2CE1B01CB8042F1	FASTA	80	9,860
	10 20 30 40 50 60 AANGNFNGSE SKRSRTAYTR HQILELEKEF HFNRYLTRRR RIEIAHALDL SERQIKIWFQ 70 80 NRRMKWKKEH KLPNTKLRLP

References

[1]	"Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary implications." Kmita-Cunisse M., Loosli F., Bierne J., Gehring W.J. Proc. Natl. Acad. Sci. U.S.A. 95:3030-3035(1998) [PubMed: 9501210] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

3D structure databases
SMR	P81192. Positions 12-71.
ModBase	Search...
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. Partial match. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA4_LINSA

Accession

Primary (citable) accession number: P81192

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)