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P81192 (HXA4_LINSA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A4
Alternative name(s):
LsHox 4
Gene names
Name:HOXA4
OrganismLineus sanguineus (Ribbon worm)
Taxonomic identifier48190 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaNemerteaAnoplaHeteronemerteaLineidaeLineus

Protein attributes

Sequence length80 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›80›80Homeobox protein Hox-A4
PRO_0000200056

Regions

DNA binding21 – 8060Homeobox

Experimental info

Non-terminal residue11
Non-terminal residue801

Sequences

Sequence LengthMass (Da)Tools
P81192 [UniParc].

Last modified July 15, 1998. Version 1.
Checksum: F2CE1B01CB8042F1

FASTA809,860
        10         20         30         40         50         60 
AANGNFNGSE SKRSRTAYTR HQILELEKEF HFNRYLTRRR RIEIAHALDL SERQIKIWFQ 

        70         80 
NRRMKWKKEH KLPNTKLRLP 

« Hide

References

[1]"Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary implications."
Kmita-Cunisse M., Loosli F., Bierne J., Gehring W.J.
Proc. Natl. Acad. Sci. U.S.A. 95:3030-3035(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

3D structure databases

ProteinModelPortalP81192.
SMRP81192. Positions 15-71.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXA4_LINSA
AccessionPrimary (citable) accession number: P81192
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries