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Protein

Zinc finger protein Helios

Gene

Ikzf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with Ikaros at centromeric heterochromatin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Helios
Alternative name(s):
Ikaros family zinc finger protein 2
Gene namesi
Name:Ikzf2
Synonyms:Helios, Zfpn1a2, Znfn1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1342541. Ikzf2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470931 – 526Zinc finger protein HeliosAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei288N6-acetyllysineBy similarity1
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP81183.
PaxDbiP81183.
PRIDEiP81183.

PTM databases

iPTMnetiP81183.
PhosphoSitePlusiP81183.

Expressioni

Tissue specificityi

Restricted to the T-cell lineage. Abundant in thymus, low expression in bone marrow and brain and no detectable expression in spleen, liver, kidney or muscle.

Gene expression databases

BgeeiENSMUSG00000025997.
CleanExiMM_IKZF2.
ExpressionAtlasiP81183. baseline and differential.
GenevisibleiP81183. MM.

Interactioni

Subunit structurei

Interacts with IKZF4 AND IKZF5.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi204701. 1 interactor.
CORUMiP81183.
STRINGi10090.ENSMUSP00000027146.

Structurei

3D structure databases

ProteinModelPortaliP81183.
SMRiP81183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG004752.
InParanoidiP81183.
KOiK09220.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1050.10. 1 hit.
InterProiView protein in InterPro
IPR026939. At2g23090-like.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 6 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P81183-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METDAIDGYI TCDNELSPEG EHANMAIDLT SSTPNGQHAS PSHMTSTNSV
60 70 80 90 100
KLEMQSDEEC DRQPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQDLQ
110 120 130 140 150
GEGGIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT
160 170 180 190 200
QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY
210 220 230 240 250
CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP MEDCKEQEPI
260 270 280 290 300
MDNNISLVPF ERPAVIEKLT ANMGKRKSST PQKFVGEKLM RFSYPDIHFD
310 320 330 340 350
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHA PSTIAEVAPV
360 370 380 390 400
ISSAYSQVYH PNRIERPISR ETSDSHENNM DGPISLIRPK SRPQEREASP
410 420 430 440 450
SNSCLDSTDS ESSHDDRQSY QGNPALNPKR KQSPAYMKED VKALDATKAP
460 470 480 490 500
KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF LDHVMYTIHM GCHGYRDPLE
510 520
CNICGYRSQD RYEFSSHIVR GEHTFH
Length:526
Mass (Da):59,401
Last modified:July 27, 2011 - v2
Checksum:iD70217FE9CCC2F7D
GO
Isoform A (identifier: P81183-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.

Show »
Length:500
Mass (Da):56,592
Checksum:i953343DD5F14593F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti384I → T in AAC00513 (PubMed:9512513).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006846111 – 136Missing in isoform A. CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044257 mRNA. Translation: AAC00513.1.
AK047925 mRNA. Translation: BAC33191.1.
CH466548 Genomic DNA. Translation: EDL00252.1.
BC138606 mRNA. Translation: AAI38607.1.
BC138608 mRNA. Translation: AAI38609.1.
CCDSiCCDS15026.1. [P81183-1]
RefSeqiNP_035900.2. NM_011770.4. [P81183-1]
XP_006496029.1. XM_006495966.3. [P81183-1]
XP_006496030.1. XM_006495967.3. [P81183-1]
XP_017175888.1. XM_017320399.1. [P81183-1]
UniGeneiMm.106343.

Genome annotation databases

EnsembliENSMUST00000027146; ENSMUSP00000027146; ENSMUSG00000025997. [P81183-1]
ENSMUST00000187184; ENSMUSP00000141075; ENSMUSG00000025997. [P81183-2]
GeneIDi22779.
KEGGimmu:22779.
UCSCiuc007bjd.2. mouse. [P81183-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIKZF2_MOUSE
AccessioniPrimary (citable) accession number: P81183
Secondary accession number(s): Q8C8A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families