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Protein

Zinc finger protein Helios

Gene

Ikzf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with Ikaros at centromeric heterochromatin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Helios
Alternative name(s):
Ikaros family zinc finger protein 2
Gene namesi
Name:Ikzf2
Synonyms:Helios, Zfpn1a2, Znfn1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1342541. Ikzf2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470931 – 526Zinc finger protein HeliosAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei288N6-acetyllysineBy similarity1
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP81183.
PaxDbiP81183.
PRIDEiP81183.

PTM databases

iPTMnetiP81183.
PhosphoSitePlusiP81183.

Expressioni

Tissue specificityi

Restricted to the T-cell lineage. Abundant in thymus, low expression in bone marrow and brain and no detectable expression in spleen, liver, kidney or muscle.

Gene expression databases

BgeeiENSMUSG00000025997.
CleanExiMM_IKZF2.
ExpressionAtlasiP81183. baseline and differential.
GenevisibleiP81183. MM.

Interactioni

Subunit structurei

Interacts with IKZF4 AND IKZF5.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi204701. 1 interactor.
STRINGi10090.ENSMUSP00000027146.

Structurei

3D structure databases

ProteinModelPortaliP81183.
SMRiP81183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri112 – 134C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 523C2H2-type 6PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG004752.
InParanoidiP81183.
KOiK09220.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P81183-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METDAIDGYI TCDNELSPEG EHANMAIDLT SSTPNGQHAS PSHMTSTNSV
60 70 80 90 100
KLEMQSDEEC DRQPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQDLQ
110 120 130 140 150
GEGGIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT
160 170 180 190 200
QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY
210 220 230 240 250
CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP MEDCKEQEPI
260 270 280 290 300
MDNNISLVPF ERPAVIEKLT ANMGKRKSST PQKFVGEKLM RFSYPDIHFD
310 320 330 340 350
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHA PSTIAEVAPV
360 370 380 390 400
ISSAYSQVYH PNRIERPISR ETSDSHENNM DGPISLIRPK SRPQEREASP
410 420 430 440 450
SNSCLDSTDS ESSHDDRQSY QGNPALNPKR KQSPAYMKED VKALDATKAP
460 470 480 490 500
KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF LDHVMYTIHM GCHGYRDPLE
510 520
CNICGYRSQD RYEFSSHIVR GEHTFH
Length:526
Mass (Da):59,401
Last modified:July 27, 2011 - v2
Checksum:iD70217FE9CCC2F7D
GO
Isoform A (identifier: P81183-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-136: Missing.

Show »
Length:500
Mass (Da):56,592
Checksum:i953343DD5F14593F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti384I → T in AAC00513 (PubMed:9512513).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006846111 – 136Missing in isoform A. CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044257 mRNA. Translation: AAC00513.1.
AK047925 mRNA. Translation: BAC33191.1.
CH466548 Genomic DNA. Translation: EDL00252.1.
BC138606 mRNA. Translation: AAI38607.1.
BC138608 mRNA. Translation: AAI38609.1.
CCDSiCCDS15026.1. [P81183-1]
RefSeqiNP_035900.2. NM_011770.4. [P81183-1]
XP_006496029.1. XM_006495966.3. [P81183-1]
XP_006496030.1. XM_006495967.3. [P81183-1]
XP_017175888.1. XM_017320399.1. [P81183-1]
UniGeneiMm.106343.

Genome annotation databases

EnsembliENSMUST00000027146; ENSMUSP00000027146; ENSMUSG00000025997. [P81183-1]
ENSMUST00000187184; ENSMUSP00000141075; ENSMUSG00000025997. [P81183-2]
GeneIDi22779.
KEGGimmu:22779.
UCSCiuc007bjd.2. mouse. [P81183-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044257 mRNA. Translation: AAC00513.1.
AK047925 mRNA. Translation: BAC33191.1.
CH466548 Genomic DNA. Translation: EDL00252.1.
BC138606 mRNA. Translation: AAI38607.1.
BC138608 mRNA. Translation: AAI38609.1.
CCDSiCCDS15026.1. [P81183-1]
RefSeqiNP_035900.2. NM_011770.4. [P81183-1]
XP_006496029.1. XM_006495966.3. [P81183-1]
XP_006496030.1. XM_006495967.3. [P81183-1]
XP_017175888.1. XM_017320399.1. [P81183-1]
UniGeneiMm.106343.

3D structure databases

ProteinModelPortaliP81183.
SMRiP81183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204701. 1 interactor.
STRINGi10090.ENSMUSP00000027146.

PTM databases

iPTMnetiP81183.
PhosphoSitePlusiP81183.

Proteomic databases

MaxQBiP81183.
PaxDbiP81183.
PRIDEiP81183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027146; ENSMUSP00000027146; ENSMUSG00000025997. [P81183-1]
ENSMUST00000187184; ENSMUSP00000141075; ENSMUSG00000025997. [P81183-2]
GeneIDi22779.
KEGGimmu:22779.
UCSCiuc007bjd.2. mouse. [P81183-1]

Organism-specific databases

CTDi22807.
MGIiMGI:1342541. Ikzf2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000049114.
HOVERGENiHBG004752.
InParanoidiP81183.
KOiK09220.
TreeFamiTF331189.

Miscellaneous databases

PROiP81183.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025997.
CleanExiMM_IKZF2.
ExpressionAtlasiP81183. baseline and differential.
GenevisibleiP81183. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIKZF2_MOUSE
AccessioniPrimary (citable) accession number: P81183
Secondary accession number(s): Q8C8A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.