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P81181

- G6PI_LACLA

UniProt

P81181 - G6PI_LACLA

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901Proton donorBy similarity
Active sitei311 – 3111By similarity
Active sitei425 – 4251By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-2304-MONOMER.
MetaCyc:MONOMER-13046.
SABIO-RKP81181.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Synonyms:pgiA
Ordered Locus Names:LL2168
ORF Names:L0012
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 448447Glucose-6-phosphate isomerasePRO_0000180660Add
BLAST

PTM databases

PhosSiteiP0809343.

Interactioni

Protein-protein interaction databases

STRINGi272623.L0012.

Structurei

3D structure databases

ProteinModelPortaliP81181.
SMRiP81181. Positions 3-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiKNMTHIT.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81181-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHIKFDYSK LTPFVAENEL DEIQWQIDGA AKLLHEGKGA GSDYIGWLDL
60 70 80 90 100
PEDYDKEEFA RIQKAAKKIQ SDSEVLIVIG IGGSYLGARA AIDFLSNSFV
110 120 130 140 150
NLQTAEERKA PRILYAGNSI SSSYLADLVD YVADKDFSVN VISKSGTTTE
160 170 180 190 200
PAIAFRVFEE MLVKKYGREE ANKRIYATTD KEKGAVKVNA DANNWETFVV
210 220 230 240 250
PDSVGGRFSV LTAVGLLPIA ASGADITALM EGANAARKEY TSTNVHENDA
260 270 280 290 300
YAYAALRNIL YRKGKFSEIL INYEPSLQYF SEWWKQLAGE SEGKDQKGIY
310 320 330 340 350
PTSANFSTDL HSLGQWIQEG TRTVFETAIR IEKPRKNINI PELDADLDGL
360 370 380 390 400
GYLQGKDVDF VNKKAADGVL LAHTDGNVPN MIVTLPEQDE FTLGYAIYFF
410 420 430 440
ELAIGVSGYL NGINPFNQPG VEAYKKNMFA LLGKPGFEEL SKELNDRL
Length:448
Mass (Da):49,595
Last modified:January 23, 2007 - v3
Checksum:i582AD419B00BB5C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06266.1.
PIRiH86895.
RefSeqiNP_268325.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK06266; AAK06266; L0012.
GeneIDi1115845.
KEGGilla:L0012.
PATRICi22296880. VBILacLac136773_2328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06266.1 .
PIRi H86895.
RefSeqi NP_268325.1. NC_002662.1.

3D structure databases

ProteinModelPortali P81181.
SMRi P81181. Positions 3-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L0012.

PTM databases

PhosSitei P0809343.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK06266 ; AAK06266 ; L0012 .
GeneIDi 1115845.
KEGGi lla:L0012.
PATRICi 22296880. VBILacLac136773_2328.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100403.
KOi K01810.
OMAi KNMTHIT.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci LLAC272623:GHSH-2304-MONOMER.
MetaCyc:MONOMER-13046.
SABIO-RK P81181.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.
  2. "The N-terminal sequence of Lactococcus lactis phosphoglucose isomerase purified by affinity chromatography differs from the other species."
    Nomura M., Nakajima I., Matsuzaki M., Kimoto H., Suzuki I., Aso H.
    Arch. Biochem. Biophys. 341:315-320(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-20.

Entry informationi

Entry nameiG6PI_LACLA
AccessioniPrimary (citable) accession number: P81181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3