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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901Proton donorBy similarity
Active sitei311 – 3111By similarity
Active sitei425 – 4251By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-2304-MONOMER.
MetaCyc:MONOMER-13046.
SABIO-RKP81181.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Synonyms:pgiA
Ordered Locus Names:LL2168
ORF Names:L0012
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 448447Glucose-6-phosphate isomerasePRO_0000180660Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L0012.

Structurei

3D structure databases

ProteinModelPortaliP81181.
SMRiP81181. Positions 3-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHIKFDYSK LTPFVAENEL DEIQWQIDGA AKLLHEGKGA GSDYIGWLDL
60 70 80 90 100
PEDYDKEEFA RIQKAAKKIQ SDSEVLIVIG IGGSYLGARA AIDFLSNSFV
110 120 130 140 150
NLQTAEERKA PRILYAGNSI SSSYLADLVD YVADKDFSVN VISKSGTTTE
160 170 180 190 200
PAIAFRVFEE MLVKKYGREE ANKRIYATTD KEKGAVKVNA DANNWETFVV
210 220 230 240 250
PDSVGGRFSV LTAVGLLPIA ASGADITALM EGANAARKEY TSTNVHENDA
260 270 280 290 300
YAYAALRNIL YRKGKFSEIL INYEPSLQYF SEWWKQLAGE SEGKDQKGIY
310 320 330 340 350
PTSANFSTDL HSLGQWIQEG TRTVFETAIR IEKPRKNINI PELDADLDGL
360 370 380 390 400
GYLQGKDVDF VNKKAADGVL LAHTDGNVPN MIVTLPEQDE FTLGYAIYFF
410 420 430 440
ELAIGVSGYL NGINPFNQPG VEAYKKNMFA LLGKPGFEEL SKELNDRL
Length:448
Mass (Da):49,595
Last modified:January 23, 2007 - v3
Checksum:i582AD419B00BB5C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06266.1.
PIRiH86895.
RefSeqiNP_268325.1. NC_002662.1.
WP_010906353.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK06266; AAK06266; L0012.
GeneIDi1115845.
KEGGilla:L0012.
PATRICi22296880. VBILacLac136773_2328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK06266.1.
PIRiH86895.
RefSeqiNP_268325.1. NC_002662.1.
WP_010906353.1. NC_002662.1.

3D structure databases

ProteinModelPortaliP81181.
SMRiP81181. Positions 3-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK06266; AAK06266; L0012.
GeneIDi1115845.
KEGGilla:L0012.
PATRICi22296880. VBILacLac136773_2328.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciLLAC272623:GHSH-2304-MONOMER.
MetaCyc:MONOMER-13046.
SABIO-RKP81181.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.
  2. "The N-terminal sequence of Lactococcus lactis phosphoglucose isomerase purified by affinity chromatography differs from the other species."
    Nomura M., Nakajima I., Matsuzaki M., Kimoto H., Suzuki I., Aso H.
    Arch. Biochem. Biophys. 341:315-320(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-20.

Entry informationi

Entry nameiG6PI_LACLA
AccessioniPrimary (citable) accession number: P81181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.