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P81181 (G6PI_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Synonyms:pgiA
Ordered Locus Names:LL2168
ORF Names:L0012
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 448447Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180660

Sites

Active site2901Proton donor By similarity
Active site3111 By similarity
Active site4251 By similarity

Sequences

Sequence LengthMass (Da)Tools
P81181 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 582AD419B00BB5C2

FASTA44849,595
        10         20         30         40         50         60 
MAHIKFDYSK LTPFVAENEL DEIQWQIDGA AKLLHEGKGA GSDYIGWLDL PEDYDKEEFA 

        70         80         90        100        110        120 
RIQKAAKKIQ SDSEVLIVIG IGGSYLGARA AIDFLSNSFV NLQTAEERKA PRILYAGNSI 

       130        140        150        160        170        180 
SSSYLADLVD YVADKDFSVN VISKSGTTTE PAIAFRVFEE MLVKKYGREE ANKRIYATTD 

       190        200        210        220        230        240 
KEKGAVKVNA DANNWETFVV PDSVGGRFSV LTAVGLLPIA ASGADITALM EGANAARKEY 

       250        260        270        280        290        300 
TSTNVHENDA YAYAALRNIL YRKGKFSEIL INYEPSLQYF SEWWKQLAGE SEGKDQKGIY 

       310        320        330        340        350        360 
PTSANFSTDL HSLGQWIQEG TRTVFETAIR IEKPRKNINI PELDADLDGL GYLQGKDVDF 

       370        380        390        400        410        420 
VNKKAADGVL LAHTDGNVPN MIVTLPEQDE FTLGYAIYFF ELAIGVSGYL NGINPFNQPG 

       430        440 
VEAYKKNMFA LLGKPGFEEL SKELNDRL 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.
[2]"The N-terminal sequence of Lactococcus lactis phosphoglucose isomerase purified by affinity chromatography differs from the other species."
Nomura M., Nakajima I., Matsuzaki M., Kimoto H., Suzuki I., Aso H.
Arch. Biochem. Biophys. 341:315-320(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK06266.1.
PIRH86895.
RefSeqNP_268325.1. NC_002662.1.

3D structure databases

ProteinModelPortalP81181.
SMRP81181. Positions 3-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L0012.

PTM databases

PhosSiteP0809343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK06266; AAK06266; L0012.
GeneID1115845.
KEGGlla:L0012.
PATRIC22296880. VBILacLac136773_2328.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OMAKNMTHIT.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-2304-MONOMER.
MetaCyc:MONOMER-13046.
SABIO-RKP81181.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LACLA
AccessionPrimary (citable) accession number: P81181
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways