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P81181

- G6PI_LACLA

UniProt

P81181 - G6PI_LACLA

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei290 – 2901Proton donorBy similarity
    Active sitei311 – 3111By similarity
    Active sitei425 – 4251By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-2304-MONOMER.
    MetaCyc:MONOMER-13046.
    SABIO-RKP81181.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Synonyms:pgiA
    Ordered Locus Names:LL2168
    ORF Names:L0012
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 448447Glucose-6-phosphate isomerasePRO_0000180660Add
    BLAST

    PTM databases

    PhosSiteiP0809343.

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L0012.

    Structurei

    3D structure databases

    ProteinModelPortaliP81181.
    SMRiP81181. Positions 3-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OMAiKNMTHIT.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P81181-1 [UniParc]FASTAAdd to Basket

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    MAHIKFDYSK LTPFVAENEL DEIQWQIDGA AKLLHEGKGA GSDYIGWLDL    50
    PEDYDKEEFA RIQKAAKKIQ SDSEVLIVIG IGGSYLGARA AIDFLSNSFV 100
    NLQTAEERKA PRILYAGNSI SSSYLADLVD YVADKDFSVN VISKSGTTTE 150
    PAIAFRVFEE MLVKKYGREE ANKRIYATTD KEKGAVKVNA DANNWETFVV 200
    PDSVGGRFSV LTAVGLLPIA ASGADITALM EGANAARKEY TSTNVHENDA 250
    YAYAALRNIL YRKGKFSEIL INYEPSLQYF SEWWKQLAGE SEGKDQKGIY 300
    PTSANFSTDL HSLGQWIQEG TRTVFETAIR IEKPRKNINI PELDADLDGL 350
    GYLQGKDVDF VNKKAADGVL LAHTDGNVPN MIVTLPEQDE FTLGYAIYFF 400
    ELAIGVSGYL NGINPFNQPG VEAYKKNMFA LLGKPGFEEL SKELNDRL 448
    Length:448
    Mass (Da):49,595
    Last modified:January 23, 2007 - v3
    Checksum:i582AD419B00BB5C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK06266.1.
    PIRiH86895.
    RefSeqiNP_268325.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK06266; AAK06266; L0012.
    GeneIDi1115845.
    KEGGilla:L0012.
    PATRICi22296880. VBILacLac136773_2328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK06266.1 .
    PIRi H86895.
    RefSeqi NP_268325.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali P81181.
    SMRi P81181. Positions 3-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L0012.

    PTM databases

    PhosSitei P0809343.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK06266 ; AAK06266 ; L0012 .
    GeneIDi 1115845.
    KEGGi lla:L0012.
    PATRICi 22296880. VBILacLac136773_2328.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OMAi KNMTHIT.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci LLAC272623:GHSH-2304-MONOMER.
    MetaCyc:MONOMER-13046.
    SABIO-RK P81181.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.
    2. "The N-terminal sequence of Lactococcus lactis phosphoglucose isomerase purified by affinity chromatography differs from the other species."
      Nomura M., Nakajima I., Matsuzaki M., Kimoto H., Suzuki I., Aso H.
      Arch. Biochem. Biophys. 341:315-320(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-20.

    Entry informationi

    Entry nameiG6PI_LACLA
    AccessioniPrimary (citable) accession number: P81181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3