P81181 (G6PI_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Synonyms:	pgiA
Ordered Locus Names:	LL2168
ORF Names:	L0012

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 448	447	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180660
Sites
	Active site	290	1	Proton donor By similarity
	Active site	311	1	By similarity
	Active site	425	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81181 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 582AD419B00BB5C2	FASTA	448	49,595
	10 20 30 40 50 60 MAHIKFDYSK LTPFVAENEL DEIQWQIDGA AKLLHEGKGA GSDYIGWLDL PEDYDKEEFA 70 80 90 100 110 120 RIQKAAKKIQ SDSEVLIVIG IGGSYLGARA AIDFLSNSFV NLQTAEERKA PRILYAGNSI 130 140 150 160 170 180 SSSYLADLVD YVADKDFSVN VISKSGTTTE PAIAFRVFEE MLVKKYGREE ANKRIYATTD 190 200 210 220 230 240 KEKGAVKVNA DANNWETFVV PDSVGGRFSV LTAVGLLPIA ASGADITALM EGANAARKEY 250 260 270 280 290 300 TSTNVHENDA YAYAALRNIL YRKGKFSEIL INYEPSLQYF SEWWKQLAGE SEGKDQKGIY 310 320 330 340 350 360 PTSANFSTDL HSLGQWIQEG TRTVFETAIR IEKPRKNINI PELDADLDGL GYLQGKDVDF 370 380 390 400 410 420 VNKKAADGVL LAHTDGNVPN MIVTLPEQDE FTLGYAIYFF ELAIGVSGYL NGINPFNQPG 430 440 VEAYKKNMFA LLGKPGFEEL SKELNDRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
[2]	"The N-terminal sequence of Lactococcus lactis phosphoglucose isomerase purified by affinity chromatography differs from the other species." Nomura M., Nakajima I., Matsuzaki M., Kimoto H., Suzuki I., Aso H. Arch. Biochem. Biophys. 341:315-320(1997) [PubMed: 9169021] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-20.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK06266.1.
PIR	H86895.
RefSeq	NP_268325.1. NC_002662.1.
3D structure databases
ProteinModelPortal	P81181.
SMR	P81181. Positions 3-448.
ModBase	Search...
PTM databases
PhosSite	P81181.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1115845.
GenomeReviews	Gene locus LL2168 in contig AE005176_GR.
KEGG	lla:L0012.
NMPDR	fig|272623.1.peg.2223.
PATRIC	22296880. VBILacLac136773_2328.
Phylogenomic databases
HOGENOM	HBG615843.
OMA	GQGNDFL.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	LLAC272623:L0012-MONOMER. MetaCyc:MONOMER-13046.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_LACLA

Accession

Primary (citable) accession number: P81181

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program