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P81178

- ALDH2_MESAU

UniProt

P81178 - ALDH2_MESAU

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Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei169 – 1691Transition state stabilizerBy similarity
Active sitei268 – 2681Proton acceptorPROSITE-ProRule annotation
Active sitei302 – 3021NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi245 – 2506NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP81178.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
ALDH-E2
ALDH1
Gene namesi
Name:ALDH2
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Aldehyde dehydrogenase, mitochondrialPRO_0000056468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-acetyllysineBy similarity
Modified residuei56 – 561N6-acetyllysineBy similarity
Modified residuei61 – 611N6-acetyllysineBy similarity
Modified residuei142 – 1421N6-acetyllysineBy similarity
Modified residuei351 – 3511N6-acetyllysineBy similarity
Modified residuei358 – 3581N6-acetyllysineBy similarity
Modified residuei366 – 3661N6-acetyllysineBy similarity
Modified residuei390 – 3901N6-acetyllysineBy similarity
Modified residuei409 – 4091N6-acetyllysineBy similarity
Modified residuei411 – 4111N6-acetyllysineBy similarity
Modified residuei424 – 4241N6-acetyllysineBy similarity
Modified residuei434 – 4341N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP81178.

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP81178.
SMRiP81178. Positions 7-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOVERGENiHBG000097.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81178-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SAAATSAVPA PNQQPEVFCN QIFINNEWHD AVSKKTFPTV NPSTGEVICQ
60 70 80 90 100
VAEGSKEDVD KAVKAARAAF QLGSPWRRMD ASDRGRLLNR LADLIERDRT
110 120 130 140 150
YLAALETLDN GKPYVISYLV DLDMVLKCLR YYAGWADKYH GKTIPIDGDF
160 170 180 190 200
FSYTRHEPVG VCGQIIPWNF PLLMQAWKLG PALATGNVVV MKVAEQTPLT
210 220 230 240 250
ALYVANLIKE AGFPPGVVNI VPGFGPTAGA AIASHEDVDK VAFTGSTEVG
260 270 280 290 300
HLIQVAAGSS NLKRVTLELG GKSPNIIMSD ADMDWAVEQA HFALFFNQGQ
310 320 330 340 350
CCCAGSRTFV QEDVYDEFVE RSVARAKSRV VGNPFDSRTE QGPQVDETQF
360 370 380 390 400
KKILGYIKSG QQEGAKLLCG GGAAADRGYF IQPTVFGDVK DGMTIAKEEI
410 420 430 440 450
FGPVMQILKF KTIEEVVGRA NNSKYGLAAA VFTKDLDKAN YLSQALQAGT
460 470 480 490 500
VWINCYDVFG AQSPFGGYKM SGSGRELGEY GLQAYTEVKT VTIKVPQKNS
Length:500
Mass (Da):54,334
Last modified:July 15, 1998 - v1
Checksum:i8B81886AB04F493F
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P81178.
SMRi P81178. Positions 7-500.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P81178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000097.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .
SABIO-RK P81178.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Class 2 aldehyde dehydrogenase. Characterization of the hamster enzyme, sensitive to daidzin and conserved within the family of multiple forms."
    Hjelmqvist L., Lundgren R., Norin A., Joernvall H., Vallee B., Klyosov A., Keung W.M.
    FEBS Lett. 416:99-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Liver.
  2. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
    Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
    Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiALDH2_MESAU
AccessioniPrimary (citable) accession number: P81178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3