Reviewed,
UniProtKB/Swiss-Prot P81178 (ALDH2_MESAU)
Last modified
November 24, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase, mitochondrial EC=1.2.1.3 Alternative name(s): ALDH class 2 ALDH1 ALDH-E2 | ||
| Gene names |
| ||
| Organism | Mesocricetus auratus (Golden hamster) | ||
| Taxonomic identifier | 10036 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus |
Protein attributes
| Sequence length | 500 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | An aldehyde + NAD+ + H2O = an acid + NADH. |
| Pathway | Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. |
| Subunit structure | Homotetramer. |
| Subcellular location | |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 500 | 500 | Aldehyde dehydrogenase, mitochondrial | PRO_0000056468 | |||||
Regions | |||||||||
| Nucleotide binding | 245 – 250 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 268 | 1 | Proton acceptor By similarity | ||||||
| Active site | 302 | 1 | Nucleophile By similarity | ||||||
| Site | 169 | 1 | Transition state stabilizer By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 351 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
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References
| [1] | "Class 2 aldehyde dehydrogenase. Characterization of the hamster enzyme, sensitive to daidzin and conserved within the family of multiple forms." Hjelmqvist L., Lundgren R., Norin A., Joernvall H., Vallee B., Klyosov A., Keung W.M. FEBS Lett. 416:99-102(1997) [PubMed: 9369242] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver. |
Cross-references
3D structure databases | |
|---|---|
| SMR | P81178. Positions 7-500. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P81178. |
Enzyme and pathway databases | |
| BRENDA | 1.2.1.3. 824. |
Family and domain databases | |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALDH2_MESAU | ||||||||
| Accession | Primary (citable) accession number: P81178 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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