Reviewed, UniProtKB/Swiss-Prot P81140 (GCDH_PIG)

Names and origin

Protein names

Recommended name:
    Glutaryl-CoA dehydrogenase, mitochondrial
      Short name=GCD
    EC=1.3.99.7

Gene names

Name:

GCDH

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	408 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.
Catalytic activity	Glutaryl-CoA + acceptor = crotonoyl-CoA + CO(2) + reduced acceptor.
Cofactor	FAD.
Pathway	Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro glutaryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	‹1 – 13	›13	Mitochondrion
	Chain	14 – 408	395	Glutaryl-CoA dehydrogenase, mitochondrial		PRO_0000000529
Sites
	Active site	384	1	Proton acceptor Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P81140-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: E517D565A193E146	FASTA	408	45,123
	10 20 30 40 50 60 KGGKTQGRSA KSSRPEFDWR DPLVLEEQLT ADEILIRDTF RTYCQEHLMP RIVLANRNEV 70 80 90 100 110 120 FHREIISEMG ELGVLGPTIK GYGCAGVSSV AYGLLARELE RVDSGYRSAM SVQSSLVMHP 130 140 150 160 170 180 IYAYGSEEQQ QQKYLPRLAK GELLGCFGLT EPNHGSDPGS METRALHNPS NRSYTLNGAK 190 200 210 220 230 240 TWITNSPVAD LFVVWARCED NCIRGFLLEK GMRGLSAPKI EGKFSLRASA TGMIIMDDVE 250 260 270 280 290 300 VPEENVLPKA SSLAVPFGCL NNARYGISWG VLGAAEFCLH TARQYTLDRI QFGVPLAKNQ 310 320 330 340 350 360 LIQRKLADML TEITLGLHAC LQLGRLKDQD KVTPEMVSLL KRNNCGKALD IARQARDMLG 370 380 390 400 GNGISDEYHV IRHAMNLEAV NTYEGTHDIH ALILGRAITG IQAFTTDK

References

[1]	"Pork and human cDNAs encoding glutaryl-CoA dehydrogenase." Goodman S.I., Kratz L.E., Frerman F.E. Prog. Clin. Biol. Res. 375:169-173(1992) [PubMed: 1438360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 14-38 AND 375-407. Tissue: Liver.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1BUC based on UniProtKB Q06319.
SMR	P81140. Positions 16-405.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P81140.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006089. Acyl-CoA_DHase_CS. IPR006092. Acyl-CoA_DHase_N. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. False negative. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCDH_PIG

Accession

Primary (citable) accession number: P81140

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 25, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)