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Protein

Beta-soluble NSF attachment protein

Gene

NAPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:NAPB
Synonyms:SNAPB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Beta-soluble NSF attachment proteinPRO_0000219059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei26 – 261PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP81126.
PRIDEiP81126.

Expressioni

Tissue specificityi

Brain.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043745.

Structurei

3D structure databases

ProteinModelPortaliP81126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP81126.
OMAiQAGSAFC.
OrthoDBiEOG7FNC80.
TreeFamiTF316547.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

P81126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIFEQIGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,555
Last modified:January 1, 1998 - v1
Checksum:iCDA8912B93A6C27E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114061 mRNA. Translation: AAI14062.1.
PIRiS32368.
RefSeqiNP_001039698.1. NM_001046233.2.
UniGeneiBt.53898.

Genome annotation databases

EnsembliENSBTAT00000046446; ENSBTAP00000043745; ENSBTAG00000032704.
GeneIDi517728.
KEGGibta:517728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114061 mRNA. Translation: AAI14062.1.
PIRiS32368.
RefSeqiNP_001039698.1. NM_001046233.2.
UniGeneiBt.53898.

3D structure databases

ProteinModelPortaliP81126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043745.

Proteomic databases

PaxDbiP81126.
PRIDEiP81126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046446; ENSBTAP00000043745; ENSBTAG00000032704.
GeneIDi517728.
KEGGibta:517728.

Organism-specific databases

CTDi63908.

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
GeneTreeiENSGT00390000005826.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP81126.
OMAiQAGSAFC.
OrthoDBiEOG7FNC80.
TreeFamiTF316547.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SNAP family of NSF attachment proteins includes a brain-specific isoform."
    Whiteheart S.W., Griff I.C., Brunner M., Clary D.O., Mayer T., Buhrow S.A., Rothman J.E.
    Nature 362:353-355(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiSNAB_BOVIN
AccessioniPrimary (citable) accession number: P81126
Secondary accession number(s): Q29RR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.