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P81124

- GSTO_APLCA

UniProt

P81124 - GSTO_APLCA

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Protein
Probable glutathione transferase
Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei3 – 31Nucleophile By similarityBy similarity
Binding sitei30 – 301Glutathione By similarity
Binding sitei43 – 431Glutathione; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB-EC
  2. glutathione transferase activity Source: UniProtKB-EC
  3. methylarsonate reductase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Protein 9
OrganismiAplysia californica (California sea hare)
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›92›92Probable glutathione transferase
PRO_0000291311Add
BLAST

Expressioni

Inductioni

By treatment with KCl and serotonin.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP81124.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 71›71GST N-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 562Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P81124-1 [UniParc]FASTAAdd to Basket

« Hide

RTCPYAQRAR LIIAAKGISA DLVNVDLNKK PDHFFDLNPY GEVPVVLHNG   50
GHVYESLIAA EYLEEAFPDP PLFAKEALVR ANERIYFNHA TK 92
Length:92
Mass (Da):10,351
Last modified:January 1, 1998 - v1
Checksum:iF7C6B9ECA950CF14
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei92 – 921

Cross-referencesi

3D structure databases

ProteinModelPortali P81124.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia."
    Noel F., Koumenis C., Nunez-Regueiro M., Raju U., Byrne J.H., Eskin A.
    Proc. Natl. Acad. Sci. U.S.A. 91:4150-4154(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-36 AND 56-92, NUCLEOTIDE SEQUENCE [MRNA] OF 37-55, INDUCTION.
    Tissue: Abdominal ganglion.

Entry informationi

Entry nameiGSTO_APLCA
AccessioniPrimary (citable) accession number: P81124
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3