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P81124

- GSTO_APLCA

UniProt

P81124 - GSTO_APLCA

Protein

Probable glutathione transferase

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity
    2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
    Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei3 – 31NucleophileBy similarity
    Binding sitei30 – 301GlutathioneBy similarity
    Binding sitei43 – 431Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB-EC
    2. glutathione transferase activity Source: UniProtKB-EC
    3. methylarsonate reductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione transferase (EC:2.5.1.18)
    Alternative name(s):
    Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
    Monomethylarsonic acid reductase (EC:1.20.4.2)
    Short name:
    MMA(V) reductase
    Protein 9
    OrganismiAplysia californica (California sea hare)
    Taxonomic identifieri6500 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›92›92Probable glutathione transferasePRO_0000291311Add
    BLAST

    Expressioni

    Inductioni

    By treatment with KCl and serotonin.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP81124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 71›71GST N-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 562Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Omega family.Sequence Analysis
    Contains 1 GST N-terminal domain.Curated

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P81124-1 [UniParc]FASTAAdd to Basket

    « Hide

    RTCPYAQRAR LIIAAKGISA DLVNVDLNKK PDHFFDLNPY GEVPVVLHNG   50
    GHVYESLIAA EYLEEAFPDP PLFAKEALVR ANERIYFNHA TK 92
    Length:92
    Mass (Da):10,351
    Last modified:January 1, 1998 - v1
    Checksum:iF7C6B9ECA950CF14
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 111 Publication
    Non-terminal residuei92 – 9211 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P81124.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia."
      Noel F., Koumenis C., Nunez-Regueiro M., Raju U., Byrne J.H., Eskin A.
      Proc. Natl. Acad. Sci. U.S.A. 91:4150-4154(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-36 AND 56-92, NUCLEOTIDE SEQUENCE [MRNA] OF 37-55, INDUCTION.
      Tissue: Abdominal ganglion1 Publication.

    Entry informationi

    Entry nameiGSTO_APLCA
    AccessioniPrimary (citable) accession number: P81124
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3