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Protein

Probable glutathione transferase

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3NucleophileBy similarity1
Binding sitei30GlutathioneBy similarity1
Binding sitei43Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Protein 9
OrganismiAplysia californica (California sea hare)
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000291311‹1 – ›92Probable glutathione transferaseAdd BLAST›92

Expressioni

Inductioni

By treatment with KCl and serotonin.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP81124.
SMRiP81124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 71GST N-terminalAdd BLAST›71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 56Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Sequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF13417. GST_N_3. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Fragment.

P81124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RTCPYAQRAR LIIAAKGISA DLVNVDLNKK PDHFFDLNPY GEVPVVLHNG
60 70 80 90
GHVYESLIAA EYLEEAFPDP PLFAKEALVR ANERIYFNHA TK
Length:92
Mass (Da):10,351
Last modified:January 1, 1998 - v1
Checksum:iF7C6B9ECA950CF14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11 Publication1
Non-terminal residuei921 Publication1

Cross-referencesi

3D structure databases

ProteinModelPortaliP81124.
SMRiP81124.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF13417. GST_N_3. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50404. GST_NTER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGSTO_APLCA
AccessioniPrimary (citable) accession number: P81124
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: May 10, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.