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P81124 (GSTO_APLCA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glutathione transferase

EC=2.5.1.18
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase
EC=1.8.5.1
Monomethylarsonic acid reductase
Short name=MMA(V) reductase
EC=1.20.4.2
Protein 9
OrganismAplysia californica (California sea hare)
Taxonomic identifier6500 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Protein attributes

Sequence length92 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione. UniProtKB P78417

2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Induction

By treatment with KCl and serotonin. Ref.1

Sequence similarities

Belongs to the GST superfamily. Omega family.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›92›92Probable glutathione transferase
PRO_0000291311

Regions

Domain‹1 – 71›71GST N-terminal
Region55 – 562Glutathione binding By similarity

Sites

Active site31Nucleophile By similarity UniProtKB P78417
Binding site301Glutathione By similarity
Binding site431Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Experimental info

Non-terminal residue11
Non-terminal residue921

Sequences

Sequence LengthMass (Da)Tools
P81124 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: F7C6B9ECA950CF14

FASTA9210,351
        10         20         30         40         50         60 
RTCPYAQRAR LIIAAKGISA DLVNVDLNKK PDHFFDLNPY GEVPVVLHNG GHVYESLIAA 

        70         80         90 
EYLEEAFPDP PLFAKEALVR ANERIYFNHA TK 

« Hide

References

[1]"Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia."
Noel F., Koumenis C., Nunez-Regueiro M., Raju U., Byrne J.H., Eskin A.
Proc. Natl. Acad. Sci. U.S.A. 91:4150-4154(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-36 AND 56-92, NUCLEOTIDE SEQUENCE [MRNA] OF 37-55, INDUCTION.
Tissue: Abdominal ganglion.

Cross-references

3D structure databases

ProteinModelPortalP81124.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTO_APLCA
AccessionPrimary (citable) accession number: P81124
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families