P81113 (ABA3_CRYAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Alboaggregin-A subunit 3
Organism	Cryptelytrops albolabris (White-lipped pit viper) (Trimeresurus albolabris)
Taxonomic identifier	8765 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Crotalinae › Cryptelytrops

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to platelet GPIb/IX receptor system and stimulates agglutination.
Subunit structure	Heterotetramer of the subunits 1, 2, 3 and 4; disulfide-linked.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Secreted
Ligand	Lectin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Alboaggregin-A subunit 3		PRO_0000046710
Regions
	Domain	1 – 125	125	C-type lectin
Amino acid modifications
	Disulfide bond	4 ↔ 15		By similarity
	Disulfide bond	32 ↔ 121		By similarity
	Disulfide bond	98 ↔ 113		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P81113 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: CAFA24C098DF3293	FASTA	125	14,799
	10 20 30 40 50 60 GFDCPFGWSS YEGYCYKVYN KKMNWEDAES FCREQHKRSH LVSFHSSGEV DFVVSKTFPI 70 80 90 100 110 120 LRYDFVWMGL SDIWKECTKE WSDGARLDYK AWSGKSYCLV SKTTNNEWLS MDCSRTRYPV CKFXG

References

[1]	"Alboaggregins A and B. Structure and interaction with human platelets." Kowalska M.A., Tan L., Holt J.C., Peng M., Karczewski J., Calvete J.J., Niewiarowski S. Thromb. Haemost. 79:609-613(1998) [PubMed: 9531050] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.
+	Additional computationally mapped references.

Cross-references

3D structure databases
ProteinModelPortal	P81113.
SMR	P81113. Positions 1-123.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004151.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABA3_CRYAB

Accession

Primary (citable) accession number: P81113

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	September 21, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program