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Protein

AMP deaminase 1

Gene

AMPD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

AMP deaminase plays a critical role in energy metabolism.

Catalytic activityi

AMP + H2O = IMP + NH3.

Pathwayi

GO - Molecular functioni

  1. AMP deaminase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

ReactomeiREACT_309543. Purine salvage.
UniPathwayiUPA00591; UER00663.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminase 1 (EC:3.5.4.6)
Alternative name(s):
AMP deaminase isoform M
Myoadenylate deaminase
Gene namesi
Name:AMPD1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›26›26AMP deaminase 1PRO_0000194406Add
BLAST

Proteomic databases

PaxDbiP81073.

Expressioni

Gene expression databases

ExpressionAtlasiP81073. baseline.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003242.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1816.
HOGENOMiHOG000092200.
InParanoidiP81073.

Sequencei

Sequence statusi: Fragment.

P81073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MNQKHLLRFI KKSYRVDADR VVYDAK
Length:26
Mass (Da):3,195
Last modified:November 1, 1997 - v1
Checksum:iB03E296D63BB6E75
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei26 – 261

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003242.

Proteomic databases

PaxDbiP81073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG1816.
HOGENOMiHOG000092200.
InParanoidiP81073.

Enzyme and pathway databases

UniPathwayiUPA00591; UER00663.
ReactomeiREACT_309543. Purine salvage.

Gene expression databases

ExpressionAtlasiP81073. baseline.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "AMP-deaminases from chicken and rabbit muscle: partial primary sequences of homologous 17-kDa CNBr fragments: autorecognition by rabbit anti-[chicken AMPD]."
    Chilson O.P., Kelly-Chilson A.E., Siegel N.R.
    Comp. Biochem. Physiol. 116B:371-377(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Mammary gland.

Entry informationi

Entry nameiAMPD1_CHICK
AccessioniPrimary (citable) accession number: P81073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.