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Protein

AMP deaminase 1

Gene

AMPD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

AMP deaminase plays a critical role in energy metabolism.

Catalytic activityi

AMP + H2O = IMP + NH3.

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. AMP deaminase 1 (AMPD1)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from AMP, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00591; UER00663.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminase 1 (EC:3.5.4.6)
Alternative name(s):
AMP deaminase isoform M
Myoadenylate deaminase
Gene namesi
Name:AMPD1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000194406‹1 – ›26AMP deaminase 1Add BLAST›26

Proteomic databases

PaxDbiP81073.

Expressioni

Gene expression databases

BgeeiENSGALG00000002082.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003242.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1096. Eukaryota.
COG1816. LUCA.
HOGENOMiHOG000092200.
InParanoidiP81073.
OrthoDBiEOG091G01OU.

Sequencei

Sequence statusi: Fragment.

P81073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MNQKHLLRFI KKSYRVDADR VVYDAK
Length:26
Mass (Da):3,195
Last modified:November 1, 1997 - v1
Checksum:iB03E296D63BB6E75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei261

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003242.

Proteomic databases

PaxDbiP81073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1096. Eukaryota.
COG1816. LUCA.
HOGENOMiHOG000092200.
InParanoidiP81073.
OrthoDBiEOG091G01OU.

Enzyme and pathway databases

UniPathwayiUPA00591; UER00663.

Gene expression databases

BgeeiENSGALG00000002082.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiAMPD1_CHICK
AccessioniPrimary (citable) accession number: P81073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.