P81073 (AMPD1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
AMP deaminase 1
EC=3.5.4.6

Alternative name(s):
AMP deaminase isoform M
Myoadenylate deaminase

Gene names

Name:

AMPD1

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	26 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	AMP deaminase plays a critical role in energy metabolism.
Catalytic activity	AMP + H2O = IMP + NH3.
Pathway	Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	IMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	AMP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›26	›26	AMP deaminase 1		PRO_0000194406
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	26	1

Sequences

	Sequence		Length	Mass (Da)
	P81073 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B03E296D63BB6E75	FASTA	26	3,195
	10 20 MNQKHLLRFI KKSYRVDADR VVYDAK

References

[1]

"AMP-deaminases from chicken and rabbit muscle: partial primary sequences of homologous 17-kDa CNBr fragments: autorecognition by rabbit anti-[chicken AMPD]." Chilson O.P., Kelly-Chilson A.E., Siegel N.R. Comp. Biochem. Physiol. 116B:371-377(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Mammary gland.

Cross-references

Sequence databases
IPI	IPI00583378.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000003242.
Proteomic databases
PaxDb	P81073.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000040045; ENSGALP00000039253; ENSGALG00000002082.
Phylogenomic databases
eggNOG	COG1816.
GeneTree	ENSGT00390000008190.
HOGENOM	HOG000092200.
InParanoid	P81073.
OrthoDB	EOG402WRH.
Enzyme and pathway databases
UniPathway	UPA00591; UER00663.
Family and domain databases
PROSITE	PS00485. A_DEAMINASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPD1_CHICK

Accession

Primary (citable) accession number: P81073

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program