Reviewed, UniProtKB/Swiss-Prot P81073 (AMPD1_CHICK)

Names and origin

Protein names

Recommended name:
    AMP deaminase 1
    EC=3.5.4.6
Alternative name(s):
    Myoadenylate deaminase
    AMP deaminase isoform M

Gene names

Name:

AMPD1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	26 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	AMP deaminase plays a critical role in energy metabolism.
Catalytic activity	AMP + H2O = IMP + NH3.
Pathway	Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	AMP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›26	›26	AMP deaminase 1		PRO_0000194406
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	26	1

Sequences

	Sequence		Length	Mass (Da)
	P81073-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B03E296D63BB6E75	FASTA	26	3,195
	10 20 MNQKHLLRFI KKSYRVDADR VVYDAK

References

[1]

"AMP-deaminases from chicken and rabbit muscle: partial primary sequences of homologous 17-kDa CNBr fragments: autorecognition by rabbit anti-[chicken AMPD]." Chilson O.P., Kelly-Chilson A.E., Siegel N.R. Comp. Biochem. Physiol. 116B:371-377(1997) [PubMed: 9114497] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Mammary gland.

Cross-references

Sequence databases
IPI	IPI00583378.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P81073.
Genome annotation databases
Ensembl	ENSGALT00000003247; ENSGALP00000003242; ENSGALG00000002082; Gallus gallus. [Genome view] ENSGALT00000040045; ENSGALP00000039253; ENSGALG00000002082; Gallus gallus. [Genome view]
Phylogenomic databases
eggNOG	veNOG10964.
HOGENOM	HBG713563.
HOVERGEN	P81073.
InParanoid	P81073.
Enzyme and pathway databases
BRENDA	3.5.4.6. 4.
Family and domain databases
PROSITE	PS00485. A_DEAMINASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPD1_CHICK

Accession

Primary (citable) accession number: P81073

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)