Reviewed, UniProtKB/Swiss-Prot P81071 (TRYP_FELCA)

Names and origin

Protein names	Recommended name:     Trypsin     EC=3.4.21.4
Organism	Felis catus (Cat) (Felis silvestris catus)
Taxonomic identifier	9685 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	16 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Cofactor	Binds 1 calcium ion per subunit By similarity.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the peptidase S1 family.

Ontologies

Keywords
Biological process	Digestion
Cellular component	Secreted
Ligand	Calcium
Molecular function	Hydrolase Protease Serine protease
PTM	Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	digestion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 8	8	Activation peptide		PRO_0000028195
	Chain	9 – ›16	›8	Trypsin		PRO_0000028196
Experimental info
	Non-terminal residue	16	1

Sequences

	Sequence		Length	Mass (Da)
	P81071-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: A6D751BB58760A86	FASTA	16	1,825
	10 FPIDDDDKIV GGYTNR

References

[1]	"Purification and partial characterization of feline trypsin." Steiner J.M., Medinger T.L., Williams D.A. Comp. Biochem. Physiol. 116B:87-93(1997) [PubMed: 9080665] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P81071.
Enzyme and pathway databases
BRENDA	3.4.21.4. 273949.
Family and domain databases
PROSITE	PS50240. TRYPSIN_DOM. Partial match. PS00134. TRYPSIN_HIS. Partial match. PS00135. TRYPSIN_SER. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRYP_FELCA

Accession

Primary (citable) accession number: P81071

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)