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Reviewed, UniProtKB/Swiss-Prot P81071 (TRYP_FELCA)

Last modified November 24, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Trypsin
    EC=3.4.21.4
OrganismFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length16 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   LigandCalcium
   Molecular functionHydrolase
Protease
Serine protease
   PTMZymogen
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 88Activation peptide
PRO_0000028195
Chain9 – ›16›8Trypsin
PRO_0000028196

Experimental info

Non-terminal residue161

Sequences

Sequence LengthMass (Da)Tools
P81071-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A6D751BB58760A86

FASTA161,825
        10 
FPIDDDDKIV GGYTNR 

« Hide

References

[1]"Purification and partial characterization of feline trypsin."
Steiner J.M., Medinger T.L., Williams D.A.
Comp. Biochem. Physiol. 116B:87-93(1997) [PubMed: 9080665] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Pancreas.

Cross-references

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENP81071.

Enzyme and pathway databases

BRENDA3.4.21.4. 273949.

Family and domain databases

PROSITEPS50240. TRYPSIN_DOM. Partial match.
PS00134. TRYPSIN_HIS. Partial match.
PS00135. TRYPSIN_SER. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYP_FELCA
AccessionPrimary (citable) accession number: P81071
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents