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Protein

GA-binding protein subunit beta-2

Gene

Gabpb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein subunit beta-2
Short name:
GABP subunit beta-2
Short name:
GABPB-2
Alternative name(s):
GA-binding protein beta-2-1
Short name:
GABP subunit beta-2-1
Short name:
GABPB2-1
Gene namesi
Name:Gabpb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95612 Gabpb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669951 – 414GA-binding protein subunit beta-2Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP81069
MaxQBiP81069
PaxDbiP81069
PeptideAtlasiP81069
PRIDEiP81069

PTM databases

iPTMnetiP81069
PhosphoSitePlusiP81069

Expressioni

Tissue specificityi

High levels in thymus, spleen, kidney and intestine.

Gene expression databases

BgeeiENSMUSG00000038766
CleanExiMM_GABPB2
ExpressionAtlasiP81069 baseline and differential
GenevisibleiP81069 MM

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2 (PubMed:16412436).1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096470

Structurei

3D structure databases

ProteinModelPortaliP81069
SMRiP81069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 34ANK 1Add BLAST30
Repeati37 – 66ANK 2Add BLAST30
Repeati70 – 99ANK 3Add BLAST30
Repeati103 – 132ANK 4Add BLAST30
Repeati136 – 166ANK 5Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili310 – 362Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 292Poly-Glu8

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IE1V Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144124
HOGENOMiHOG000231772
HOVERGENiHBG051686
InParanoidiP81069
KOiK09454
OMAiQVAEETI
OrthoDBiEOG091G0AIM
PhylomeDBiP81069
TreeFamiTF326036

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P81069-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH
60 70 80 90 100
YSTAEVLLRA GVSRDARTKV DRTPLHMAAA DGHVHIVELL VRSGADVNAK
110 120 130 140 150
DMLQMTALHW ATEHHHRDVV ELLIKYGADV YAFSKFDKSA FDIAMEKNNT
160 170 180 190 200
EILVMLQEAM QNQVNTNHER ANPVANPVTV TAPFIFTSGE VINLASFVSS
210 220 230 240 250
ANTKATSAHL EEMEEGNSLD SSTQQVVGSG GQRVITIVTD GVPLGNIQTS
260 270 280 290 300
LPAGGIGQPF IVTMQDGQQV LTVPAGQVAE ETIIEDEEEE EEKLPLVKRP
310 320 330 340 350
RMAEMTNRVE EMKEGSEREL LQQQLQEANR RAQEYRHQLL KKEQEAEQYR
360 370 380 390 400
LRLEAMAQQQ TNGVEVDVTV VEEVAEVDAV VVTEGDEVER ATQVMKSGRT
410
TEPHTNVSIE TISS
Length:414
Mass (Da):45,658
Last modified:March 18, 2008 - v2
Checksum:i7F601EF08DB6C5A2
GO
Isoform 2 (identifier: P81069-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-269: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):39,282
Checksum:iFC27BBAAC9D15487
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24T → I no nucleotide entry (PubMed:7958862).Curated1
Sequence conflicti118D → L no nucleotide entry (PubMed:7958862).Curated1
Sequence conflicti292Missing no nucleotide entry (PubMed:7958862).Curated1
Sequence conflicti347E → EC no nucleotide entry (PubMed:7958862).Curated1
Sequence conflicti361T → R no nucleotide entry (PubMed:7958862).Curated1
Sequence conflicti367D → Q no nucleotide entry (PubMed:7958862).Curated1
Sequence conflicti372 – 373EE → QQ no nucleotide entry (PubMed:7958862).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032473208 – 269Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030849 mRNA Translation: BAC27157.1
AK141382 mRNA Translation: BAE24666.1
BC150160 mRNA Translation: AAI50161.1
BC150482 mRNA Translation: AAI50483.1
CCDSiCCDS17605.1 [P81069-1]
PIRiA53950
RefSeqiNP_084161.1, NM_029885.1 [P81069-1]
NP_766100.1, NM_172512.2 [P81069-1]
XP_006501313.1, XM_006501250.3 [P81069-1]
XP_006501314.1, XM_006501251.3 [P81069-1]
XP_006501315.1, XM_006501252.3 [P81069-1]
XP_011238360.1, XM_011240058.2 [P81069-1]
XP_011238361.1, XM_011240059.2 [P81069-1]
XP_011238362.1, XM_011240060.2 [P81069-1]
XP_011238363.1, XM_011240061.2 [P81069-1]
XP_017175004.1, XM_017319515.1 [P81069-2]
UniGeneiMm.224820

Genome annotation databases

EnsembliENSMUST00000098873; ENSMUSP00000096470; ENSMUSG00000038766 [P81069-1]
ENSMUST00000107209; ENSMUSP00000102827; ENSMUSG00000038766 [P81069-1]
ENSMUST00000136139; ENSMUSP00000121283; ENSMUSG00000038766 [P81069-1]
GeneIDi213054
KEGGimmu:213054
UCSCiuc008qin.2 mouse [P81069-1]
uc008qip.2 mouse [P81069-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGABP2_MOUSE
AccessioniPrimary (citable) accession number: P81069
Secondary accession number(s): A7E218, Q8CDA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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