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Protein

GA-binding protein subunit beta-2

Gene

Gabpb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats). Must associate with GABP-alpha to bind DNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein subunit beta-2
Short name:
GABP subunit beta-2
Short name:
GABPB-2
Alternative name(s):
GA-binding protein beta-2-1
Short name:
GABP subunit beta-2-1
Short name:
GABPB2-1
Gene namesi
Name:Gabpb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95612. Gabpb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414GA-binding protein subunit beta-2PRO_0000066995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei218 – 2181PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP81069.
MaxQBiP81069.
PaxDbiP81069.
PRIDEiP81069.

PTM databases

iPTMnetiP81069.
PhosphoSiteiP81069.

Expressioni

Tissue specificityi

High levels in thymus, spleen, kidney and intestine.

Gene expression databases

BgeeiP81069.
CleanExiMM_GABPB2.
ExpressionAtlasiP81069. baseline and differential.
GenevisibleiP81069. MM.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2 (PubMed:16412436).1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096470.

Structurei

3D structure databases

ProteinModelPortaliP81069.
SMRiP81069. Positions 5-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3430ANK 1Add
BLAST
Repeati37 – 6630ANK 2Add
BLAST
Repeati70 – 9930ANK 3Add
BLAST
Repeati103 – 13230ANK 4Add
BLAST
Repeati136 – 16631ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili310 – 36253Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi285 – 2928Poly-Glu

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IE1V. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129826.
HOGENOMiHOG000231772.
HOVERGENiHBG051686.
InParanoidiP81069.
KOiK09454.
OMAiQVAEETI.
OrthoDBiEOG7ZD1W2.
PhylomeDBiP81069.
TreeFamiTF326036.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P81069-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH
60 70 80 90 100
YSTAEVLLRA GVSRDARTKV DRTPLHMAAA DGHVHIVELL VRSGADVNAK
110 120 130 140 150
DMLQMTALHW ATEHHHRDVV ELLIKYGADV YAFSKFDKSA FDIAMEKNNT
160 170 180 190 200
EILVMLQEAM QNQVNTNHER ANPVANPVTV TAPFIFTSGE VINLASFVSS
210 220 230 240 250
ANTKATSAHL EEMEEGNSLD SSTQQVVGSG GQRVITIVTD GVPLGNIQTS
260 270 280 290 300
LPAGGIGQPF IVTMQDGQQV LTVPAGQVAE ETIIEDEEEE EEKLPLVKRP
310 320 330 340 350
RMAEMTNRVE EMKEGSEREL LQQQLQEANR RAQEYRHQLL KKEQEAEQYR
360 370 380 390 400
LRLEAMAQQQ TNGVEVDVTV VEEVAEVDAV VVTEGDEVER ATQVMKSGRT
410
TEPHTNVSIE TISS
Length:414
Mass (Da):45,658
Last modified:March 18, 2008 - v2
Checksum:i7F601EF08DB6C5A2
GO
Isoform 2 (identifier: P81069-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-269: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):39,282
Checksum:iFC27BBAAC9D15487
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241T → I no nucleotide entry (PubMed:7958862).Curated
Sequence conflicti118 – 1181D → L no nucleotide entry (PubMed:7958862).Curated
Sequence conflicti292 – 2921Missing no nucleotide entry (PubMed:7958862).Curated
Sequence conflicti347 – 3471E → EC no nucleotide entry (PubMed:7958862).Curated
Sequence conflicti361 – 3611T → R no nucleotide entry (PubMed:7958862).Curated
Sequence conflicti367 – 3671D → Q no nucleotide entry (PubMed:7958862).Curated
Sequence conflicti372 – 3732EE → QQ no nucleotide entry (PubMed:7958862).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 26962Missing in isoform 2. 1 PublicationVSP_032473Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030849 mRNA. Translation: BAC27157.1.
AK141382 mRNA. Translation: BAE24666.1.
BC150160 mRNA. Translation: AAI50161.1.
BC150482 mRNA. Translation: AAI50483.1.
CCDSiCCDS17605.1. [P81069-1]
PIRiA53950.
RefSeqiNP_084161.1. NM_029885.1. [P81069-1]
NP_766100.1. NM_172512.2. [P81069-1]
XP_006501313.1. XM_006501250.2. [P81069-1]
XP_006501314.1. XM_006501251.2. [P81069-1]
XP_006501315.1. XM_006501252.2. [P81069-1]
XP_011238360.1. XM_011240058.1. [P81069-1]
XP_011238361.1. XM_011240059.1. [P81069-1]
XP_011238362.1. XM_011240060.1. [P81069-1]
XP_011238363.1. XM_011240061.1. [P81069-1]
UniGeneiMm.224820.

Genome annotation databases

EnsembliENSMUST00000098873; ENSMUSP00000096470; ENSMUSG00000038766. [P81069-1]
ENSMUST00000107209; ENSMUSP00000102827; ENSMUSG00000038766. [P81069-1]
ENSMUST00000136139; ENSMUSP00000121283; ENSMUSG00000038766. [P81069-1]
GeneIDi213054.
KEGGimmu:213054.
UCSCiuc008qin.2. mouse. [P81069-1]
uc008qip.2. mouse. [P81069-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030849 mRNA. Translation: BAC27157.1.
AK141382 mRNA. Translation: BAE24666.1.
BC150160 mRNA. Translation: AAI50161.1.
BC150482 mRNA. Translation: AAI50483.1.
CCDSiCCDS17605.1. [P81069-1]
PIRiA53950.
RefSeqiNP_084161.1. NM_029885.1. [P81069-1]
NP_766100.1. NM_172512.2. [P81069-1]
XP_006501313.1. XM_006501250.2. [P81069-1]
XP_006501314.1. XM_006501251.2. [P81069-1]
XP_006501315.1. XM_006501252.2. [P81069-1]
XP_011238360.1. XM_011240058.1. [P81069-1]
XP_011238361.1. XM_011240059.1. [P81069-1]
XP_011238362.1. XM_011240060.1. [P81069-1]
XP_011238363.1. XM_011240061.1. [P81069-1]
UniGeneiMm.224820.

3D structure databases

ProteinModelPortaliP81069.
SMRiP81069. Positions 5-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096470.

PTM databases

iPTMnetiP81069.
PhosphoSiteiP81069.

Proteomic databases

EPDiP81069.
MaxQBiP81069.
PaxDbiP81069.
PRIDEiP81069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098873; ENSMUSP00000096470; ENSMUSG00000038766. [P81069-1]
ENSMUST00000107209; ENSMUSP00000102827; ENSMUSG00000038766. [P81069-1]
ENSMUST00000136139; ENSMUSP00000121283; ENSMUSG00000038766. [P81069-1]
GeneIDi213054.
KEGGimmu:213054.
UCSCiuc008qin.2. mouse. [P81069-1]
uc008qip.2. mouse. [P81069-2]

Organism-specific databases

CTDi126626.
MGIiMGI:95612. Gabpb2.

Phylogenomic databases

eggNOGiENOG410IE1V. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129826.
HOGENOMiHOG000231772.
HOVERGENiHBG051686.
InParanoidiP81069.
KOiK09454.
OMAiQVAEETI.
OrthoDBiEOG7ZD1W2.
PhylomeDBiP81069.
TreeFamiTF326036.

Miscellaneous databases

PROiP81069.
SOURCEiSearch...

Gene expression databases

BgeeiP81069.
CleanExiMM_GABPB2.
ExpressionAtlasiP81069. baseline and differential.
GenevisibleiP81069. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor."
    Jeong B.C., Kim M.Y., Lee J.H., Kee H.J., Kho D.H., Han K.E., Qian Y.R., Kim J.K., Kim K.K.
    FEBS Lett. 580:669-676(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADGRB2.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Spleen.

Entry informationi

Entry nameiGABP2_MOUSE
AccessioniPrimary (citable) accession number: P81069
Secondary accession number(s): A7E218, Q8CDA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 18, 2008
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.