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Protein

Penaeidin-3a

Gene
N/A
Organism
Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antibacterial activity against M.luteus and E.coli bacteria. Antifungal activity against N.crassa and F.oxysporum. Presents chitin-binding activity.2 Publications

GO - Molecular functioni

  • chitin binding Source: UniProtKB

GO - Biological processi

  • defense response to bacterium Source: UniProtKB
  • defense response to fungus Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Fungicide

Keywords - Ligandi

Chitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Penaeidin-3a
Short name:
P3-a
Short name:
Pen-3a
OrganismiLitopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
Taxonomic identifieri6689 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaeLitopenaeus

Subcellular locationi

  • Cytoplasmic granule 1 Publication

  • Note: Cytoplasmic granules of hemocytes and to a lesser extent in small granules of hemocytes.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 8162Penaeidin-3aPRO_0000023506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acid
Disulfide bondi51 ↔ 66
Disulfide bondi55 ↔ 73
Disulfide bondi67 ↔ 74
Modified residuei81 – 811Serine amide1 Publication

Keywords - PTMi

Amidation, Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Higher expression in hemocytes and to a lesser extent in heart, testis, gills, intestine, lymphonoid organ and hepatopancreas. Traces in eyes and subcuticular epithelium. Not present in the brain.1 Publication

Developmental stagei

Expression decreases 3 hours after microbial challenge to return to control levels after 12 hours and slightly increases after 24 hours.1 Publication

Structurei

Secondary structure

1
82
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 305Combined sources
Helixi60 – 7011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UEONMR-A20-82[»]
DisProtiDP00373.
ProteinModelPortaliP81058.
SMRiP81058. Positions 20-82.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP81058.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 4719Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the penaeidin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR009226. Penaeidin.
[Graphical view]
PfamiPF05927. Penaeidin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVVCLVFL ASFALVCQGQ VYKGGYTRPI PRPPPFVRPL PGGPIGPYNG
60 70 80
CPVSCRGISF SQARSCCSRL GRCCHVGKGY SG
Length:82
Mass (Da):8,748
Last modified:July 15, 1998 - v1
Checksum:iE60E09BB305521FD
GO

Mass spectrometryi

Molecular mass is 6617.4 Da from positions 20 - 81. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14926 mRNA. Translation: CAA75143.1.
AF387661 mRNA. Translation: AAK73084.1.
AF387662 mRNA. Translation: AAK73085.1.
AF387663 mRNA. Translation: AAK73086.1.
AF390139 mRNA. Translation: AAK77532.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14926 mRNA. Translation: CAA75143.1.
AF387661 mRNA. Translation: AAK73084.1.
AF387662 mRNA. Translation: AAK73085.1.
AF387663 mRNA. Translation: AAK73086.1.
AF390139 mRNA. Translation: AAK77532.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UEONMR-A20-82[»]
DisProtiDP00373.
ProteinModelPortaliP81058.
SMRiP81058. Positions 20-82.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP81058.

Family and domain databases

InterProiIPR009226. Penaeidin.
[Graphical view]
PfamiPF05927. Penaeidin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEN3A_LITVA
AccessioniPrimary (citable) accession number: P81058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 14, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.