Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Muscarinic toxin 3

Gene
N/A
Organism
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Potent antagonist (IC50=1-10 nM) of M4 (CHRM4) muscarinic receptors (PubMed:8154745, PubMed:24793485,PubMed:21557730), and CHRM1, ADRA1A (PubMed:8154745), ADRA2A and ADRA2C adrenergic receptors. Also antagonises ADRA1B and ADRA1D adrenergic receptors with a 10-times lower affinity (PubMed:24793485).3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled acetylcholine receptor impairing toxin, G-protein coupled receptor impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic toxin 3
Short name:
MT3
OrganismiDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Taxonomic identifieri8618 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Muscarinic toxin 3PRO_0000093642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 24By similarity
Disulfide bondi17 ↔ 42By similarity
Disulfide bondi46 ↔ 57By similarity
Disulfide bondi58 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP81031.
SMRiP81031. Positions 1-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snake three-finger toxin family. Short-chain subfamily. Aminergic toxin sub-subfamily.1 Publication

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiIPR003572. Cytotoxin.
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
[Graphical view]
PRINTSiPR00282. CYTOTOXIN.
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P81031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LTCVTKNTIF GITTENCPAG QNLCFKRWHY VIPRYTEITR GCAATCPIPE
60
NYDSIHCCKT DKCNE
Length:65
Mass (Da):7,387
Last modified:February 16, 2004 - v2
Checksum:i901B12D2F89AAFFE
GO

Sequence databases

PIRiS48648.

Cross-referencesi

Sequence databases

PIRiS48648.

3D structure databases

ProteinModelPortaliP81031.
SMRiP81031. Positions 1-65.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiIPR003572. Cytotoxin.
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
[Graphical view]
PRINTSiPR00282. CYTOTOXIN.
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei3SIM3_DENAN
AccessioniPrimary (citable) accession number: P81031
Secondary accession number(s): Q9PRH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 16, 2004
Last modified: September 7, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not show interaction with adrenergic receptors (ADRA2B, ADRB1, ADRB2), dopaminergic receptors (DRD1, DRD2, DRD3, DRD4, DRD5), histaminic receptors (HRH1, HRH3, HRH4), muscarinic receptors (CHRM1, CHRM2, CHRM3, CHRM5), and serotoninergic receptors (HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7).3 Publications

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.