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Protein

Muscarinic toxin 3

Gene
N/A
Organism
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Potent antagonist (IC50=1-10 nM) of M4 (CHRM4) muscarinic receptors (PubMed:8154745, PubMed:24793485,PubMed:21557730), and CHRM1, ADRA1A (PubMed:8154745), ADRA2A and ADRA2C adrenergic receptors. Also antagonises ADRA1B and ADRA1D adrenergic receptors with a 10-times lower affinity (PubMed:24793485).3 Publications

Miscellaneous

Does not show interaction with adrenergic receptors (ADRA2B, ADRB1, ADRB2), dopaminergic receptors (DRD1, DRD2, DRD3, DRD4, DRD5), histaminic receptors (HRH1, HRH3, HRH4), muscarinic receptors (CHRM1, CHRM2, CHRM3, CHRM5), and serotoninergic receptors (HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7).3 Publications

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled acetylcholine receptor impairing toxin, G-protein coupled receptor impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic toxin 3
Short name:
MT3
OrganismiDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Taxonomic identifieri8618 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000936421 – 65Muscarinic toxin 3Add BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 24By similarity
Disulfide bondi17 ↔ 42By similarity
Disulfide bondi46 ↔ 57By similarity
Disulfide bondi58 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP81031.
SMRiP81031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snake three-finger toxin family. Short-chain subfamily. Aminergic toxin sub-subfamily.1 Publication

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiView protein in InterPro
IPR003572. Cytotoxin.
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
IPR035076. Toxin/TOLIP.
PfamiView protein in Pfam
PF00087. Toxin_TOLIP. 1 hit.
PRINTSiPR00282. CYTOTOXIN.
PROSITEiView protein in PROSITE
PS00272. SNAKE_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P81031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LTCVTKNTIF GITTENCPAG QNLCFKRWHY VIPRYTEITR GCAATCPIPE
60
NYDSIHCCKT DKCNE
Length:65
Mass (Da):7,387
Last modified:February 16, 2004 - v2
Checksum:i901B12D2F89AAFFE
GO

Sequence databases

PIRiS48648.

Similar proteinsi

Entry informationi

Entry namei3SIM3_DENAN
AccessioniPrimary (citable) accession number: P81031
Secondary accession number(s): Q9PRH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 16, 2004
Last modified: September 27, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families