Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P81031 (TXM3_DENAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 26, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Muscarinic toxin 3

Short name=MT3
OrganismDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Taxonomic identifier8618 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

Protein attributes

Sequence length65 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to M4 (CHRM4) muscarinic acetylcholine receptors, and reveals a slightly weaker effect on M1 (CHRM1) receptors. Ref.1

Subunit structure

Monomer By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Miscellaneous

Has no effect on M2 (CHRM2), M3 (CHRM3) and M5 (CHRM5) receptors (Ref.2).

Sequence similarities

Belongs to the snake three-finger toxin family. Type A muscarinic toxin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6565Muscarinic toxin 3
PRO_0000093642

Amino acid modifications

Disulfide bond3 ↔ 24 By similarity
Disulfide bond17 ↔ 42 By similarity
Disulfide bond46 ↔ 57 By similarity
Disulfide bond58 ↔ 63 By similarity

Sequences

Sequence LengthMass (Da)Tools
P81031 [UniParc].

Last modified February 16, 2004. Version 2.
Checksum: 901B12D2F89AAFFE

FASTA657,387
        10         20         30         40         50         60 
LTCVTKNTIF GITTENCPAG QNLCFKRWHY VIPRYTEITR GCAATCPIPE NYDSIHCCKT 


DKCNE 

« Hide

References

[1]"Protein toxins that bind to muscarinic acetylcholine receptors."
Karlsson E., Jolkkonen M., Satyapan N., Adem A., Kumlin E., Hellman U., Wernstedt C.
Ann. N. Y. Acad. Sci. 710:153-161(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION.
[2]"A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors."
Jolkkonen M., van Giersbergen P.L., Hellman U., Wernstedt C., Karlsson E.
FEBS Lett. 352:91-94(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRS48648.

3D structure databases

ProteinModelPortalP81031.
SMRP81031. Positions 1-65.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006553.

Family and domain databases

InterProIPR003572. Cytotoxin.
IPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view]
PfamPF00087. Toxin_1. 1 hit.
[Graphical view]
PRINTSPR00282. CYTOTOXIN.
PROSITEPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTXM3_DENAN
AccessionPrimary (citable) accession number: P81031
Secondary accession number(s): Q9PRH6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 16, 2004
Last modified: June 26, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families