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P81031

- TXM3_DENAN

UniProt

P81031 - TXM3_DENAN

Protein

Muscarinic toxin 3

Gene
N/A
Organism
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to M4 (CHRM4) muscarinic acetylcholine receptors, and reveals a slightly weaker effect on M1 (CHRM1) receptors.1 Publication

    GO - Biological processi

    1. modification of morphology or physiology of other organism Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled acetylcholine receptor impairing toxin, G-protein coupled receptor impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Muscarinic toxin 3
    Short name:
    MT3
    OrganismiDendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
    Taxonomic identifieri8618 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeDendroaspis

    Subcellular locationi

    GO - Cellular componenti

    1. other organism postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6565Muscarinic toxin 3PRO_0000093642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 24By similarity
    Disulfide bondi17 ↔ 42By similarity
    Disulfide bondi46 ↔ 57By similarity
    Disulfide bondi58 ↔ 63By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP81031.
    SMRiP81031. Positions 1-65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG006553.

    Family and domain databases

    InterProiIPR003572. Cytotoxin.
    IPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view]
    PfamiPF00087. Toxin_1. 1 hit.
    [Graphical view]
    PRINTSiPR00282. CYTOTOXIN.
    PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P81031-1 [UniParc]FASTAAdd to Basket

    « Hide

    LTCVTKNTIF GITTENCPAG QNLCFKRWHY VIPRYTEITR GCAATCPIPE   50
    NYDSIHCCKT DKCNE 65
    Length:65
    Mass (Da):7,387
    Last modified:February 16, 2004 - v2
    Checksum:i901B12D2F89AAFFE
    GO

    Sequence databases

    PIRiS48648.

    Cross-referencesi

    Sequence databases

    PIRi S48648.

    3D structure databases

    ProteinModelPortali P81031.
    SMRi P81031. Positions 1-65.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006553.

    Family and domain databases

    InterProi IPR003572. Cytotoxin.
    IPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view ]
    Pfami PF00087. Toxin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00282. CYTOTOXIN.
    PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE, FUNCTION.
    2. "A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors."
      Jolkkonen M., van Giersbergen P.L., Hellman U., Wernstedt C., Karlsson E.
      FEBS Lett. 352:91-94(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiTXM3_DENAN
    AccessioniPrimary (citable) accession number: P81031
    Secondary accession number(s): Q9PRH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 16, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    Has no effect on M2 (CHRM2), M3 (CHRM3) and M5 (CHRM5) receptors.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3