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Protein

Seminal plasma protein BSP-30 kDa

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Displays heparin-, gelatin- and phospholipid-binding activities.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fertilization

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Seminal plasma protein BSP-30 kDa
Short name:
BSP-30K
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 183158Seminal plasma protein BSP-30 kDaPRO_0000019233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361O-linked (GalNAc...)1 Publication
Glycosylationi46 – 461O-linked (GalNAc...)1 Publication
Glycosylationi57 – 571O-linked (GalNAc...)1 Publication
Glycosylationi58 – 581O-linked (GalNAc...)1 Publication
Glycosylationi59 – 591O-linked (GalNAc...)1 Publication
Glycosylationi64 – 641O-linked (GalNAc...)1 Publication
Disulfide bondi97 ↔ 121PROSITE-ProRule annotation
Disulfide bondi111 ↔ 134PROSITE-ProRule annotation
Disulfide bondi142 ↔ 168PROSITE-ProRule annotation
Disulfide bondi156 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP81019.
PRIDEiP81019.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052231.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CEBmodel-A95-183[»]
DisProtiDP00669.
ProteinModelPortaliP81019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 13645Fibronectin type-II 1PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 18347Fibronectin type-II 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the seminal plasma protein family.Curated
Contains 2 fibronectin type-II domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00830000128424.
HOGENOMiHOG000060267.
HOVERGENiHBG007070.
InParanoidiP81019.
OMAiTERDEPE.
OrthoDBiEOG7D85Z3.
TreeFamiTF343543.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
InterProiIPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00040. fn2. 2 hits.
[Graphical view]
SMARTiSM00059. FN2. 2 hits.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 2 hits.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P81019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLVGLFLI WAGASVFQQL HPVNGGDIPD PGSKPTPPGM ADELPTETYD
60 70 80 90 100
LPPEIYTTTF LPRTIYPQEE MPYDDKPFPS LLSKANDLNA VFEGPACAFP
110 120 130 140 150
FTYKGKKYYM CTRKNSVLLW CSLDTEYQGN WKFCTERDEP ECVFPFIYRK
160 170 180
KSYESCTRVH SFFWRRWCSL TSNYDRDKAW KYC
Length:183
Mass (Da):21,269
Last modified:December 1, 2000 - v2
Checksum:i82615DFFB3AB42EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381P → S AA sequence (PubMed:8980140).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057133 mRNA. Translation: AAD17519.1.
RefSeqiNP_777267.1. NM_174842.2.
UniGeneiBt.224.

Genome annotation databases

EnsembliENSBTAT00000054953; ENSBTAP00000052231; ENSBTAG00000018882.
GeneIDi317699.
KEGGibta:317699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057133 mRNA. Translation: AAD17519.1.
RefSeqiNP_777267.1. NM_174842.2.
UniGeneiBt.224.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CEBmodel-A95-183[»]
DisProtiDP00669.
ProteinModelPortaliP81019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052231.

Proteomic databases

PaxDbiP81019.
PRIDEiP81019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000054953; ENSBTAP00000052231; ENSBTAG00000018882.
GeneIDi317699.
KEGGibta:317699.

Organism-specific databases

CTDi317699.

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00830000128424.
HOGENOMiHOG000060267.
HOVERGENiHBG007070.
InParanoidiP81019.
OMAiTERDEPE.
OrthoDBiEOG7D85Z3.
TreeFamiTF343543.

Miscellaneous databases

NextBioi20807147.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
InterProiIPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00040. fn2. 2 hits.
[Graphical view]
SMARTiSM00059. FN2. 2 hits.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 2 hits.
PROSITEiPS00023. FN2_1. 1 hit.
PS51092. FN2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete mRNA sequence of bovine seminal plasma 30K protein (BSP-30K)."
    Salois D., Menard M., Paquette Y., Manjunath P.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The primary structure of BSP-30K, a major lipid-, gelatin-, and heparin-binding glycoprotein of bovine seminal plasma."
    Calvete J.J., Mann K., Sanz L., Raida M., Toepfer-Petersen E.
    FEBS Lett. 399:147-152(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-183, GLYCOSYLATION AT THR-36; THR-46; THR-57; THR-58; THR-59 AND THR-64.
    Tissue: Seminal plasma.

Entry informationi

Entry nameiSFP4_BOVIN
AccessioniPrimary (citable) accession number: P81019
Secondary accession number(s): O97868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: April 13, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.