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P80994 (DUSP_RACVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dual specificity protein phosphatase H1 homolog

EC=3.1.3.-
EC=3.1.3.48
Gene names
ORF Names:VH1
OrganismRaccoon poxvirus (RCN)
Taxonomic identifier10256 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostProcyon lotor (Raccoon) [TaxID: 9654]

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated STAT1 and blocking interferon (IFN)-stimulated innate immune responses By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Protein serine phosphate + H2O = protein serine + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Virion By similarity. Host cytoplasm By similarity. Note: Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus By similarity.

Induction

Expressed in the late phase of the viral replicative cycle.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 171171Probable dual specificity protein phosphatase H1 homolog
PRO_0000094872

Sites

Active site1101Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P80994 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: E03416F4988B3E81

FASTA17119,741
        10         20         30         40         50         60 
MDKKSLYKYL LLRSTGDIHR AKSPTMMTRV TNNVYLGNYK NAMEAPSSEV KFKYILNLTM 

        70         80         90        100        110        120 
DKYSFTNSNI NIIHVPMVDD TSTDISIYFD DITAFLSKCD QRNEPVLVHC AAGVNRSGAM 

       130        140        150        160        170 
ILAYLMSKNK ESSPMLYFLY VYHSMRDLRG AFVENPSFKR QIIEKYVIDK N 

« Hide

References

[1]"A protein phosphatase related to the vaccinia virus VH1 is encoded in the genomes of several orthopoxviruses and a baculovirus."
Hakes D.J., Martell K.J., Zhao W.G., Massung R.F., Esposito J.J., Dixon J.E.
Proc. Natl. Acad. Sci. U.S.A. 90:4017-4021(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13165 mRNA. No translation available.
PIRB47452.

3D structure databases

ProteinModelPortalP80994.
SMRP80994. Positions 1-170.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUSP_RACVI
AccessionPrimary (citable) accession number: P80994
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families