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Cytochrome c oxidase polypeptide 7C, mitochondrial

Thunnus obesus (Bigeye tuna)
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli


This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni


Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 7C, mitochondrial (EC:
Alternative name(s):
Cytochrome c oxidase polypeptide VIIc
OrganismiThunnus obesus (Bigeye tuna)
Taxonomic identifieri8241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagiariaScombriformesScombridaeThunnus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›10›10Cytochrome c oxidase polypeptide 7C, mitochondrialPRO_0000197046

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated


Sequence statusi: Fragment.

Mass (Da):1,059
Last modified:November 1, 1997 - v1

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei10 – 101

Sequence databases



Sequence databases


3D structure databases


Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases



  1. "The subunit structure of cytochrome-c oxidase from tuna heart and liver."
    Arnold S., Lee I., Kim M., Song E., Linder D., Lottspeich F., Kadenbach B.
    Eur. J. Biochem. 248:99-103(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Heart and Liver.

Entry informationi

Entry nameiCOX7C_THUOB
AccessioniPrimary (citable) accession number: P80982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.