Reviewed, UniProtKB/Swiss-Prot P80979 (COX7A_THUOB)

Names and origin

Protein names	Recommended name:     Cytochrome c oxidase polypeptide 7A, mitochondrial     EC=1.9.3.1 Alternative name(s):     Cytochrome c oxidase polypeptide VIIa
Organism	Thunnus obesus (Bigeye tuna)
Taxonomic identifier	8241 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Scombroidei › Scombridae › Thunnus

Protein attributes

Sequence length	15 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase VIIa family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›15	›15	Cytochrome c oxidase polypeptide 7A, mitochondrial		PRO_0000221004
Amino acid modifications
	Modified residue	1	1	Blocked amino end (Xaa)
Experimental info
	Non-terminal residue	15	1

Sequences

	Sequence		Length	Mass (Da)
	P80979-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C111B99419E69A1E	FASTA	15	1,770
	10 XNYVPEAQKL FQAHN

References

[1]	"The subunit structure of cytochrome-c oxidase from tuna heart and liver." Arnold S., Lee I., Kim M., Song E., Linder D., Lottspeich F., Kadenbach B. Eur. J. Biochem. 248:99-103(1997) [PubMed: 9310366] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart and Liver.

Cross-references

Sequence databases
PIR	S77988.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P80979.
Enzyme and pathway databases
BRENDA	1.9.3.1. 296622.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

COX7A_THUOB

Accession

Primary (citable) accession number: P80979

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)