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P80971 (COX42_THUOB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name=COX IV-2
OrganismThunnus obesus (Bigeye tuna)
Taxonomic identifier8241 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeThunnus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransit peptide
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentmitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion Ref.2
Chain29 – 176148Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
PRO_0000006093

Experimental info

Sequence conflict331L → H AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P80971 [UniParc].

Last modified April 3, 2002. Version 2.
Checksum: 4EEB4EF17BC58AD4

FASTA17620,470
        10         20         30         40         50         60 
MLRLTAGRVR SLLAGRATAA FSTSSARMAS HDLEVAESVD MSKPLYWDRL DTPLPDRPYK 

        70         80         90        100        110        120 
EDLTAADKSL KQKEKGPWGQ LSKEEKIALY RLMFCQTYSE MKQPSSEWKT VFGGIFIFLG 

       130        140        150        160        170 
FTGLVVWWQA LYVYPPRPRT FDDEWKAKQL KRMLDMRVNP IEGFSAKWDY EKGQWK 

« Hide

References

[1]"New isoforms of cytochrome c oxidase subunit IV in tuna fish."
Huettemann M.
Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart, Liver and Muscle.
[2]"The subunit structure of cytochrome-c oxidase from tuna heart and liver."
Arnold S., Lee I., Kim M., Song E., Linder D., Lottspeich F., Kadenbach B.
Eur. J. Biochem. 248:99-103(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-38.
Tissue: Heart and Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF204871 mRNA. Translation: AAF79934.1.
PIRS77980.

3D structure databases

ProteinModelPortalP80971.
SMRP80971. Positions 34-176.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG051087.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
PRINTSPR01873. CYTCOXIDASE4.
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOX42_THUOB
AccessionPrimary (citable) accession number: P80971
Secondary accession number(s): Q9I8T9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2002
Last modified: June 11, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families