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P80971

- COX42_THUOB

UniProt

P80971 - COX42_THUOB

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Protein
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Gene
N/A
Organism
Thunnus obesus (Bigeye tuna)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name:
COX IV-2
OrganismiThunnus obesus (Bigeye tuna)
Taxonomic identifieri8241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeThunnus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828Mitochondrion1 Publication
Add
BLAST
Chaini29 – 176148Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
PRO_0000006093Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP80971.
SMRiP80971. Positions 34-176.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051087.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80971-1 [UniParc]FASTAAdd to Basket

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MLRLTAGRVR SLLAGRATAA FSTSSARMAS HDLEVAESVD MSKPLYWDRL    50
DTPLPDRPYK EDLTAADKSL KQKEKGPWGQ LSKEEKIALY RLMFCQTYSE 100
MKQPSSEWKT VFGGIFIFLG FTGLVVWWQA LYVYPPRPRT FDDEWKAKQL 150
KRMLDMRVNP IEGFSAKWDY EKGQWK 176
Length:176
Mass (Da):20,470
Last modified:April 3, 2002 - v2
Checksum:i4EEB4EF17BC58AD4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331L → H AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204871 mRNA. Translation: AAF79934.1.
PIRiS77980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204871 mRNA. Translation: AAF79934.1 .
PIRi S77980.

3D structure databases

ProteinModelPortali P80971.
SMRi P80971. Positions 34-176.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051087.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "New isoforms of cytochrome c oxidase subunit IV in tuna fish."
    Huettemann M.
    Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart, Liver and Muscle.
  2. "The subunit structure of cytochrome-c oxidase from tuna heart and liver."
    Arnold S., Lee I., Kim M., Song E., Linder D., Lottspeich F., Kadenbach B.
    Eur. J. Biochem. 248:99-103(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-38.
    Tissue: Heart and Liver.

Entry informationi

Entry nameiCOX42_THUOB
AccessioniPrimary (citable) accession number: P80971
Secondary accession number(s): Q9I8T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2002
Last modified: June 11, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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