Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P80971

- COX42_THUOB

UniProt

P80971 - COX42_THUOB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene
N/A
Organism
Thunnus obesus (Bigeye tuna)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name:
COX IV-2
OrganismiThunnus obesus (Bigeye tuna)
Taxonomic identifieri8241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagiariaScombriformesScombridaeThunnus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828Mitochondrion1 PublicationAdd
BLAST
Chaini29 – 176148Cytochrome c oxidase subunit 4 isoform 2, mitochondrialPRO_0000006093Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP80971.
SMRiP80971. Positions 34-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG051087.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80971-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRLTAGRVR SLLAGRATAA FSTSSARMAS HDLEVAESVD MSKPLYWDRL
60 70 80 90 100
DTPLPDRPYK EDLTAADKSL KQKEKGPWGQ LSKEEKIALY RLMFCQTYSE
110 120 130 140 150
MKQPSSEWKT VFGGIFIFLG FTGLVVWWQA LYVYPPRPRT FDDEWKAKQL
160 170
KRMLDMRVNP IEGFSAKWDY EKGQWK
Length:176
Mass (Da):20,470
Last modified:April 3, 2002 - v2
Checksum:i4EEB4EF17BC58AD4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331L → H AA sequence (PubMed:9310366)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204871 mRNA. Translation: AAF79934.1.
PIRiS77980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF204871 mRNA. Translation: AAF79934.1 .
PIRi S77980.

3D structure databases

ProteinModelPortali P80971.
SMRi P80971. Positions 34-176.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG051087.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "New isoforms of cytochrome c oxidase subunit IV in tuna fish."
    Huettemann M.
    Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart, Liver and Muscle.
  2. "The subunit structure of cytochrome-c oxidase from tuna heart and liver."
    Arnold S., Lee I., Kim M., Song E., Linder D., Lottspeich F., Kadenbach B.
    Eur. J. Biochem. 248:99-103(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-38.
    Tissue: Heart and Liver.

Entry informationi

Entry nameiCOX42_THUOB
AccessioniPrimary (citable) accession number: P80971
Secondary accession number(s): Q9I8T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2002
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3