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P80971

- COX42_THUOB

UniProt

P80971 - COX42_THUOB

Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene
N/A
Organism
Thunnus obesus (Bigeye tuna)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (03 Apr 2002)
      Previous versions | rss
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    Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase subunit IV isoform 2
    Short name:
    COX IV-2
    OrganismiThunnus obesus (Bigeye tuna)
    Taxonomic identifieri8241 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeThunnus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828Mitochondrion1 PublicationAdd
    BLAST
    Chaini29 – 176148Cytochrome c oxidase subunit 4 isoform 2, mitochondrialPRO_0000006093Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP80971.
    SMRiP80971. Positions 34-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase IV family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051087.

    Family and domain databases

    Gene3Di1.10.442.10. 1 hit.
    InterProiIPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view]
    PfamiPF02936. COX4. 1 hit.
    [Graphical view]
    PRINTSiPR01873. CYTCOXIDASE4.
    SUPFAMiSSF81406. SSF81406. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80971-1 [UniParc]FASTAAdd to Basket

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    MLRLTAGRVR SLLAGRATAA FSTSSARMAS HDLEVAESVD MSKPLYWDRL    50
    DTPLPDRPYK EDLTAADKSL KQKEKGPWGQ LSKEEKIALY RLMFCQTYSE 100
    MKQPSSEWKT VFGGIFIFLG FTGLVVWWQA LYVYPPRPRT FDDEWKAKQL 150
    KRMLDMRVNP IEGFSAKWDY EKGQWK 176
    Length:176
    Mass (Da):20,470
    Last modified:April 3, 2002 - v2
    Checksum:i4EEB4EF17BC58AD4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331L → H AA sequence (PubMed:9310366)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204871 mRNA. Translation: AAF79934.1.
    PIRiS77980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204871 mRNA. Translation: AAF79934.1 .
    PIRi S77980.

    3D structure databases

    ProteinModelPortali P80971.
    SMRi P80971. Positions 34-176.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG051087.

    Family and domain databases

    Gene3Di 1.10.442.10. 1 hit.
    InterProi IPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view ]
    Pfami PF02936. COX4. 1 hit.
    [Graphical view ]
    PRINTSi PR01873. CYTCOXIDASE4.
    SUPFAMi SSF81406. SSF81406. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "New isoforms of cytochrome c oxidase subunit IV in tuna fish."
      Huettemann M.
      Biochim. Biophys. Acta 1492:242-246(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart, Liver and Muscle.
    2. "The subunit structure of cytochrome-c oxidase from tuna heart and liver."
      Arnold S., Lee I., Kim M., Song E., Linder D., Lottspeich F., Kadenbach B.
      Eur. J. Biochem. 248:99-103(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-38.
      Tissue: Heart and Liver.

    Entry informationi

    Entry nameiCOX42_THUOB
    AccessioniPrimary (citable) accession number: P80971
    Secondary accession number(s): Q9I8T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 3, 2002
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3