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Protein

Mitochondrial import receptor subunit TOM5

Gene

TOM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.1 Publication

GO - Biological processi

  • mitochondrial outer membrane translocase complex assembly Source: SGD
  • protein targeting to mitochondrion Source: SGD
  • protein transmembrane transport Source: GOC

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34325-MONOMER

Protein family/group databases

TCDBi3.A.8.1.1 the mitochondrial protein translocase (mpt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM5
Alternative name(s):
Translocase of outer membrane 5 kDa subunit
Gene namesi
Name:TOM5
Synonyms:MOM8A
Ordered Locus Names:YPR133W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YPR133W-A
SGDiS000006433 TOM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 45Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182641 – 50Mitochondrial import receptor subunit TOM5Add BLAST50

Proteomic databases

MaxQBiP80967
PaxDbiP80967
PRIDEiP80967

Interactioni

Subunit structurei

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36300, 50 interactors
DIPiDIP-7358N
IntActiP80967, 10 interactors
STRINGi4932.YPR133W-A

Structurei

3D structure databases

ProteinModelPortaliP80967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom5 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000001005
InParanoidiP80967
KOiK17773
OMAiYVAAFLW
OrthoDBiEOG092C60LK

Family and domain databases

InterProiView protein in InterPro
IPR019603 Tom5
PfamiView protein in Pfam
PF10642 Tom5, 1 hit

Sequencei

Sequence statusi: Complete.

P80967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLPQQEVS EEEKRAHQEQ TEKTLKQAAY VAAFLWVSPM IWHLVKKQWK
Length:50
Mass (Da):5,985
Last modified:November 1, 1997 - v1
Checksum:iE1419ED5FEC45E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA No translation available.
AY558369 Genomic DNA Translation: AAS56695.1
BK006949 Genomic DNA Translation: DAA11546.1
PIRiS77712
RefSeqiNP_015459.1, NM_001184307.1

Genome annotation databases

EnsemblFungiiYPR133W-A; YPR133W-A; YPR133W-A
GeneIDi856252
KEGGisce:YPR133W-A

Similar proteinsi

Entry informationi

Entry nameiTOM5_YEAST
AccessioniPrimary (citable) accession number: P80967
Secondary accession number(s): D6W4D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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