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P80967

- TOM5_YEAST

UniProt

P80967 - TOM5_YEAST

Protein

Mitochondrial import receptor subunit TOM5

Gene

TOM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.1 Publication

    GO - Biological processi

    1. mitochondrial outer membrane translocase complex assembly Source: SGD
    2. protein targeting to mitochondrion Source: SGD
    3. protein transmembrane transport Source: GOC

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34325-MONOMER.
    ReactomeiREACT_189012. Mitochondrial protein import.

    Protein family/group databases

    TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import receptor subunit TOM5
    Alternative name(s):
    Translocase of outer membrane 5 kDa subunit
    Gene namesi
    Name:TOM5
    Synonyms:MOM8A
    Ordered Locus Names:YPR133W-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR133w-a.
    SGDiS000006433. TOM5.

    Subcellular locationi

    Mitochondrion outer membrane Curated; Single-pass membrane protein Curated
    Note: Outer membrane-anchored.Curated

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: SGD
    2. mitochondrial outer membrane Source: Reactome
    3. mitochondrial outer membrane translocase complex Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5050Mitochondrial import receptor subunit TOM5PRO_0000218264Add
    BLAST

    Proteomic databases

    MaxQBiP80967.
    PaxDbiP80967.

    Expressioni

    Gene expression databases

    GenevestigatoriP80967.

    Interactioni

    Subunit structurei

    Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TOM40P236441EBI-12501,EBI-12539
    YHR080CP388001EBI-12501,EBI-24597

    Protein-protein interaction databases

    BioGridi36300. 34 interactions.
    IntActiP80967. 4 interactions.
    MINTiMINT-4987954.
    STRINGi4932.YPR133W-A.

    Structurei

    3D structure databases

    ProteinModelPortaliP80967.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4519Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tom5 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86324.
    HOGENOMiHOG000001005.
    KOiK17773.
    OMAiPRRTCKK.
    OrthoDBiEOG7KM66K.

    Family and domain databases

    InterProiIPR019603. Tom5.
    [Graphical view]
    PfamiPF10642. Tom5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80967-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGLPQQEVS EEEKRAHQEQ TEKTLKQAAY VAAFLWVSPM IWHLVKKQWK   50
    Length:50
    Mass (Da):5,985
    Last modified:November 1, 1997 - v1
    Checksum:iE1419ED5FEC45E14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40829 Genomic DNA. No translation available.
    AY558369 Genomic DNA. Translation: AAS56695.1.
    BK006949 Genomic DNA. Translation: DAA11546.1.
    PIRiS77712.
    RefSeqiNP_015459.1. NM_001184307.1.

    Genome annotation databases

    EnsemblFungiiYPR133W-A; YPR133W-A; YPR133W-A.
    GeneIDi856252.
    KEGGisce:YPR133W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40829 Genomic DNA. No translation available.
    AY558369 Genomic DNA. Translation: AAS56695.1 .
    BK006949 Genomic DNA. Translation: DAA11546.1 .
    PIRi S77712.
    RefSeqi NP_015459.1. NM_001184307.1.

    3D structure databases

    ProteinModelPortali P80967.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36300. 34 interactions.
    IntActi P80967. 4 interactions.
    MINTi MINT-4987954.
    STRINGi 4932.YPR133W-A.

    Protein family/group databases

    TCDBi 3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

    Proteomic databases

    MaxQBi P80967.
    PaxDbi P80967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR133W-A ; YPR133W-A ; YPR133W-A .
    GeneIDi 856252.
    KEGGi sce:YPR133W-A.

    Organism-specific databases

    CYGDi YPR133w-a.
    SGDi S000006433. TOM5.

    Phylogenomic databases

    eggNOGi NOG86324.
    HOGENOMi HOG000001005.
    KOi K17773.
    OMAi PRRTCKK.
    OrthoDBi EOG7KM66K.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34325-MONOMER.
    Reactomei REACT_189012. Mitochondrial protein import.

    Miscellaneous databases

    NextBioi 981531.

    Gene expression databases

    Genevestigatori P80967.

    Family and domain databases

    InterProi IPR019603. Tom5.
    [Graphical view ]
    Pfami PF10642. Tom5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Tom5 functionally links mitochondrial preprotein receptors to the general import pore."
      Dietmeier K., Hoenlinger A., Boemer U., Dekker P.J.T., Eckerskorn C., Lottspeich F., Kuebrich M., Pfanner N.
      Nature 388:195-200(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, PROTEIN SEQUENCE OF 1-21.
    5. "Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex."
      Dekker P.J.T., Ryan M.T., Brix J., Mueller H., Hoenlinger A., Pfanner N.
      Mol. Cell. Biol. 18:6515-6524(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TOM COMPLEX.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTOM5_YEAST
    AccessioniPrimary (citable) accession number: P80967
    Secondary accession number(s): D6W4D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3