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P80967

- TOM5_YEAST

UniProt

P80967 - TOM5_YEAST

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Protein

Mitochondrial import receptor subunit TOM5

Gene
TOM5, MOM8A, YPR133W-A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.1 Publication

GO - Biological processi

  1. mitochondrial outer membrane translocase complex assembly Source: SGD
  2. protein targeting to mitochondrion Source: SGD
  3. protein transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34325-MONOMER.
ReactomeiREACT_189012. Mitochondrial protein import.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM5
Alternative name(s):
Translocase of outer membrane 5 kDa subunit
Gene namesi
Name:TOM5
Synonyms:MOM8A
Ordered Locus Names:YPR133W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR133w-a.
SGDiS000006433. TOM5.

Subcellular locationi

Mitochondrion outer membrane; Single-pass membrane protein Reviewed prediction
Note: Outer membrane-anchored Reviewed prediction.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei27 – 4519Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: SGD
  2. mitochondrial outer membrane Source: Reactome
  3. mitochondrial outer membrane translocase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5050Mitochondrial import receptor subunit TOM5PRO_0000218264Add
BLAST

Proteomic databases

MaxQBiP80967.
PaxDbiP80967.

Expressioni

Gene expression databases

GenevestigatoriP80967.

Interactioni

Subunit structurei

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TOM40P236441EBI-12501,EBI-12539
YHR080CP388001EBI-12501,EBI-24597

Protein-protein interaction databases

BioGridi36300. 34 interactions.
IntActiP80967. 4 interactions.
MINTiMINT-4987954.
STRINGi4932.YPR133W-A.

Structurei

3D structure databases

ProteinModelPortaliP80967.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom5 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86324.
HOGENOMiHOG000001005.
KOiK17773.
OMAiPRRTCKK.
OrthoDBiEOG7KM66K.

Family and domain databases

InterProiIPR019603. Tom5.
[Graphical view]
PfamiPF10642. Tom5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80967-1 [UniParc]FASTAAdd to Basket

« Hide

MFGLPQQEVS EEEKRAHQEQ TEKTLKQAAY VAAFLWVSPM IWHLVKKQWK   50
Length:50
Mass (Da):5,985
Last modified:November 1, 1997 - v1
Checksum:iE1419ED5FEC45E14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40829 Genomic DNA. No translation available.
AY558369 Genomic DNA. Translation: AAS56695.1.
BK006949 Genomic DNA. Translation: DAA11546.1.
PIRiS77712.
RefSeqiNP_015459.1. NM_001184307.1.

Genome annotation databases

EnsemblFungiiYPR133W-A; YPR133W-A; YPR133W-A.
GeneIDi856252.
KEGGisce:YPR133W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40829 Genomic DNA. No translation available.
AY558369 Genomic DNA. Translation: AAS56695.1 .
BK006949 Genomic DNA. Translation: DAA11546.1 .
PIRi S77712.
RefSeqi NP_015459.1. NM_001184307.1.

3D structure databases

ProteinModelPortali P80967.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36300. 34 interactions.
IntActi P80967. 4 interactions.
MINTi MINT-4987954.
STRINGi 4932.YPR133W-A.

Protein family/group databases

TCDBi 3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBi P80967.
PaxDbi P80967.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR133W-A ; YPR133W-A ; YPR133W-A .
GeneIDi 856252.
KEGGi sce:YPR133W-A.

Organism-specific databases

CYGDi YPR133w-a.
SGDi S000006433. TOM5.

Phylogenomic databases

eggNOGi NOG86324.
HOGENOMi HOG000001005.
KOi K17773.
OMAi PRRTCKK.
OrthoDBi EOG7KM66K.

Enzyme and pathway databases

BioCyci YEAST:G3O-34325-MONOMER.
Reactomei REACT_189012. Mitochondrial protein import.

Miscellaneous databases

NextBioi 981531.

Gene expression databases

Genevestigatori P80967.

Family and domain databases

InterProi IPR019603. Tom5.
[Graphical view ]
Pfami PF10642. Tom5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Tom5 functionally links mitochondrial preprotein receptors to the general import pore."
    Dietmeier K., Hoenlinger A., Boemer U., Dekker P.J.T., Eckerskorn C., Lottspeich F., Kuebrich M., Pfanner N.
    Nature 388:195-200(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, PROTEIN SEQUENCE OF 1-21.
  5. "Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex."
    Dekker P.J.T., Ryan M.T., Brix J., Mueller H., Hoenlinger A., Pfanner N.
    Mol. Cell. Biol. 18:6515-6524(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TOM COMPLEX.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOM5_YEAST
AccessioniPrimary (citable) accession number: P80967
Secondary accession number(s): D6W4D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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