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P80967 (TOM5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import receptor subunit TOM5
Alternative name(s):
Translocase of outer membrane 5 kDa subunit
Gene names
Name:TOM5
Synonyms:MOM8A
Ordered Locus Names:YPR133W-A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length50 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore. Ref.4

Subunit structure

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). Ref.5

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein Potential. Note: Outer membrane-anchored Potential.

Sequence similarities

Belongs to the Tom5 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TOM40P236441EBI-12501,EBI-12539
YHR080CP388001EBI-12501,EBI-24597

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5050Mitochondrial import receptor subunit TOM5
PRO_0000218264

Regions

Topological domain1 – 2626Cytoplasmic Potential
Transmembrane27 – 4519Helical; Signal-anchor for type II membrane protein; Potential

Sequences

Sequence LengthMass (Da)Tools
P80967 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: E1419ED5FEC45E14

FASTA505,985
        10         20         30         40         50 
MFGLPQQEVS EEEKRAHQEQ TEKTLKQAAY VAAFLWVSPM IWHLVKKQWK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Tom5 functionally links mitochondrial preprotein receptors to the general import pore."
Dietmeier K., Hoenlinger A., Boemer U., Dekker P.J.T., Eckerskorn C., Lottspeich F., Kuebrich M., Pfanner N.
Nature 388:195-200(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION, PROTEIN SEQUENCE OF 1-21.
[5]"Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex."
Dekker P.J.T., Ryan M.T., Brix J., Mueller H., Hoenlinger A., Pfanner N.
Mol. Cell. Biol. 18:6515-6524(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE TOM COMPLEX.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40829 Genomic DNA. No translation available.
AY558369 Genomic DNA. Translation: AAS56695.1.
BK006949 Genomic DNA. Translation: DAA11546.1.
PIRS77712.
RefSeqNP_015459.1. NM_001184307.1.

3D structure databases

ProteinModelPortalP80967.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36300. 34 interactions.
IntActP80967. 4 interactions.
MINTMINT-4987954.
STRING4932.YPR133W-A.

Protein family/group databases

TCDB3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

PaxDbP80967.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR133W-A; YPR133W-A; YPR133W-A.
GeneID856252.
KEGGsce:YPR133W-A.

Organism-specific databases

CYGDYPR133w-a.
SGDS000006433. TOM5.

Phylogenomic databases

eggNOGNOG86324.
HOGENOMHOG000001005.
KOK17773.
OMANSTVMTA.
OrthoDBEOG7KM66K.

Enzyme and pathway databases

BioCycYEAST:G3O-34325-MONOMER.
ReactomeREACT_118590. Mitochondrial Protein Import (yeast).
REACT_85873. Metabolism of proteins.

Gene expression databases

GenevestigatorP80967.

Family and domain databases

InterProIPR019603. Tom5.
[Graphical view]
PfamPF10642. Tom5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981531.

Entry information

Entry nameTOM5_YEAST
AccessionPrimary (citable) accession number: P80967
Secondary accession number(s): D6W4D0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families