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Protein

Mitochondrial import receptor subunit TOM5

Gene

TOM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM5 is involved in insertion of preproteins into the TOM40 translocation pore.1 Publication

GO - Biological processi

  1. mitochondrial outer membrane translocase complex assembly Source: SGD
  2. protein targeting to mitochondrion Source: SGD
  3. protein transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34325-MONOMER.
ReactomeiREACT_334110. Mitochondrial protein import.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM5
Alternative name(s):
Translocase of outer membrane 5 kDa subunit
Gene namesi
Name:TOM5
Synonyms:MOM8A
Ordered Locus Names:YPR133W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XVI

Organism-specific databases

CYGDiYPR133w-a.
SGDiS000006433. TOM5.

Subcellular locationi

Mitochondrion outer membrane Curated; Single-pass membrane protein Curated
Note: Outer membrane-anchored.Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei27 – 4519Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: SGD
  2. mitochondrial outer membrane Source: Reactome
  3. mitochondrial outer membrane translocase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5050Mitochondrial import receptor subunit TOM5PRO_0000218264Add
BLAST

Proteomic databases

MaxQBiP80967.
PaxDbiP80967.

Expressioni

Gene expression databases

GenevestigatoriP80967.

Interactioni

Subunit structurei

Forms part of the TOM (translocase of outer membrane) complex that consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TOM40P236441EBI-12501,EBI-12539
YHR080CP388001EBI-12501,EBI-24597

Protein-protein interaction databases

BioGridi36300. 34 interactions.
DIPiDIP-7358N.
IntActiP80967. 4 interactions.
MINTiMINT-4987954.
STRINGi4932.YPR133W-A.

Structurei

3D structure databases

ProteinModelPortaliP80967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom5 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86324.
HOGENOMiHOG000001005.
InParanoidiP80967.
KOiK17773.
OMAiNSTVMTA.
OrthoDBiEOG7KM66K.

Family and domain databases

InterProiIPR019603. Tom5.
[Graphical view]
PfamiPF10642. Tom5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P80967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLPQQEVS EEEKRAHQEQ TEKTLKQAAY VAAFLWVSPM IWHLVKKQWK
Length:50
Mass (Da):5,985
Last modified:October 31, 1997 - v1
Checksum:iE1419ED5FEC45E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA. No translation available.
AY558369 Genomic DNA. Translation: AAS56695.1.
BK006949 Genomic DNA. Translation: DAA11546.1.
PIRiS77712.
RefSeqiNP_015459.1. NM_001184307.1.

Genome annotation databases

EnsemblFungiiYPR133W-A; YPR133W-A; YPR133W-A.
GeneIDi856252.
KEGGisce:YPR133W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40829 Genomic DNA. No translation available.
AY558369 Genomic DNA. Translation: AAS56695.1.
BK006949 Genomic DNA. Translation: DAA11546.1.
PIRiS77712.
RefSeqiNP_015459.1. NM_001184307.1.

3D structure databases

ProteinModelPortaliP80967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36300. 34 interactions.
DIPiDIP-7358N.
IntActiP80967. 4 interactions.
MINTiMINT-4987954.
STRINGi4932.YPR133W-A.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBiP80967.
PaxDbiP80967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR133W-A; YPR133W-A; YPR133W-A.
GeneIDi856252.
KEGGisce:YPR133W-A.

Organism-specific databases

CYGDiYPR133w-a.
SGDiS000006433. TOM5.

Phylogenomic databases

eggNOGiNOG86324.
HOGENOMiHOG000001005.
InParanoidiP80967.
KOiK17773.
OMAiNSTVMTA.
OrthoDBiEOG7KM66K.

Enzyme and pathway databases

BioCyciYEAST:G3O-34325-MONOMER.
ReactomeiREACT_334110. Mitochondrial protein import.

Miscellaneous databases

NextBioi981531.

Gene expression databases

GenevestigatoriP80967.

Family and domain databases

InterProiIPR019603. Tom5.
[Graphical view]
PfamiPF10642. Tom5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Tom5 functionally links mitochondrial preprotein receptors to the general import pore."
    Dietmeier K., Hoenlinger A., Boemer U., Dekker P.J.T., Eckerskorn C., Lottspeich F., Kuebrich M., Pfanner N.
    Nature 388:195-200(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, PROTEIN SEQUENCE OF 1-21.
  5. "Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex."
    Dekker P.J.T., Ryan M.T., Brix J., Mueller H., Hoenlinger A., Pfanner N.
    Mol. Cell. Biol. 18:6515-6524(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TOM COMPLEX.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOM5_YEAST
AccessioniPrimary (citable) accession number: P80967
Secondary accession number(s): D6W4D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: March 31, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.