P80911 (IORB_METTM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indolepyruvate oxidoreductase subunit iorB
Short name=IOR
EC=1.2.7.8

Alternative name(s):
Indolepyruvate ferredoxin oxidoreductase subunit beta

Gene names

Name:	iorB
Ordered Locus Names:	MTBMA_c04230

Organism

Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) [Complete proteome] [HAMAP]

Taxonomic identifier

79929 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
Catalytic activity	(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterodimer of the iorA and iorB subunits. Ref.2
Biophysicochemical properties	pH dependence: Optimum pH is 10.0. Ref.2 Temperature dependence: Optimum temperature is 80 degrees Celsius.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Molecular function	indolepyruvate ferredoxin oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 196	195	Indolepyruvate oxidoreductase subunit iorB		PRO_0000099933

Sequences

	Sequence		Length	Mass (Da)
	P80911 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 35887D4852C8643C	FASTA	196	21,068
	10 20 30 40 50 60 MSYNIYVCGV GGQGIIKTSV IIGEAAMNEG MNVVMSEIHG MAQRGGAVST EIRFGDVRGS 70 80 90 100 110 120 IIPQGEADLV IAFEPLEALR ALPKMSEDAC VIVNTSKIPP FNLIKSPHPY PPLEEIIKTL 130 140 150 160 170 180 EENAGRVRSF NGEKIAVEAG HILSLNMVML GAAAATTGFP LGEETLIESM KNNLPPKLME 190 VNLRAFHEGF ETVNCD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism." Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K. J. Bacteriol. 192:5850-5851(2010) [PubMed: 20802048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
[2]	"Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum." Tersteegen A., Linder D., Thauer R.K., Hedderich R. Eur. J. Biochem. 244:862-868(1997) [PubMed: 9108258] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-29, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001710 Genomic DNA. Translation: ADL58024.1.
RefSeq	YP_003849337.1. NC_014408.1.
3D structure databases
ProteinModelPortal	P80911.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9704129.
GenomeReviews	Gene locus MTBMA_c04230 in contig CP001710_GR.
KEGG	mmg:MTBMA_c04230.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VILSFEP.
Family and domain databases
InterPro	IPR017719. Indolepyruvate_Fd_OxRdtase_bsu. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
KO	K00180.
Pfam	PF01558. POR. 1 hit. [Graphical view]
SUPFAM	SSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
TIGRFAMs	TIGR03334. IOR_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IORB_METTM

Accession

Primary (citable) accession number: P80911
Secondary accession number(s): D9PUX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 30, 2010
Last modified:	November 16, 2011
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program