Reviewed, UniProtKB/Swiss-Prot P80909 (VORC_METTM)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorC
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase gamma chain
    2-oxoisovalerate ferredoxin reductase subunit gamma

Gene names

Name:

vorC

Organism

Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133)

Taxonomic identifier

79929 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	24 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
Cofactor	Binds 2 4Fe-4S clusters By similarity.
Subunit structure	Heterotrimer of the vorA, vorB and vorC subunits.
Sequence similarities	Contains at least 1 4Fe-4S ferredoxin-type domain.
Biophysicochemical properties	pH dependence: Optimum pH is 9.7. Temperature dependence: Optimum temperature is 75 degrees Celsius.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Repeat
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›24	›24	Ketoisovalerate oxidoreductase subunit vorC		PRO_0000099960
Regions
	Domain	4 – ›24	›21	4Fe-4S ferredoxin-type
Sites
	Metal binding	13	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	16	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	19	1	Iron-sulfur 1 (4Fe-4S) Potential
Experimental info
	Sequence uncertainty	13	1
	Sequence uncertainty	16	1
	Sequence uncertainty	19	1
	Non-terminal residue	24	1

Sequences

	Sequence		Length	Mass (Da)
	P80909-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 6E3CA79596800DC9	FASTA	24	2,748
	10 20 MKKAYPVINR VECXACERCI IQAP

References

[1]	"Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum." Tersteegen A., Linder D., Thauer R.K., Hedderich R. Eur. J. Biochem. 244:862-868(1997) [PubMed: 9108258] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001450. 4Fe4S_Fe_S_bd. [Graphical view]
PROSITE	PS00198. 4FE4S_FER_1. Partial match. PS51379. 4FE4S_FER_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORC_METTM

Accession

Primary (citable) accession number: P80909

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	November 4, 2008
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)