Reviewed, UniProtKB/Swiss-Prot P80908 (VORB_METTM)

Names and origin

Protein names

Recommended name:
    Ketoisovalerate oxidoreductase subunit vorB
      Short name=VOR
    EC=1.2.7.7
Alternative name(s):
    2-oxoisovalerate oxidoreductase beta chain
    2-oxoisovalerate ferredoxin reductase subunit beta

Gene names

Name:

vorB

Organism

Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133)

Taxonomic identifier

79929 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	35 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
Subunit structure	Heterotrimer of the vorA, vorB and vorC subunits.
Biophysicochemical properties	pH dependence: Optimum pH is 9.7. Temperature dependence: Optimum temperature is 75 degrees Celsius.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›35	›35	Ketoisovalerate oxidoreductase subunit vorB		PRO_0000099955
Experimental info
	Non-terminal residue	35	1

Sequences

	Sequence		Length	Mass (Da)
	P80908-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C2AF6C43DE8629BA	FASTA	35	3,670
	10 20 30 ATQMVXGNTA VIIGAMYAGX DXYFGYPITP ASEIL

References

[1]	"Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum." Tersteegen A., Linder D., Thauer R.K., Hedderich R. Eur. J. Biochem. 244:862-868(1997) [PubMed: 9108258] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. [Graphical view]
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VORB_METTM

Accession

Primary (citable) accession number: P80908

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)