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P80908 (VORB_METTM) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketoisovalerate oxidoreductase subunit vorB

Short name=VOR
EC=1.2.7.7
Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit beta
2-oxoisovalerate oxidoreductase beta chain
Gene names
Name:vorB
Ordered Locus Names:MTBMA_c10910
OrganismMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) [Complete proteome] [HAMAP]
Taxonomic identifier79929 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Subunit structure

Heterotrimer of the vorA, vorB and vorC subunits. Ref.2

Biophysicochemical properties

pH dependence:

Optimum pH is 9.7. Ref.2

Temperature dependence:

Optimum temperature is 75 degrees Celsius.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 352351Ketoisovalerate oxidoreductase subunit vorB
PRO_0000099955

Sequences

Sequence LengthMass (Da)Tools
P80908 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 6BFE2D51CA971021

FASTA35238,549
        10         20         30         40         50         60 
MATQMVKGNT AVIIGAMYAG CDCYFGYPIT PASEILHEAS RYFPLVGRKF VQAESEEAAI 

        70         80         90        100        110        120 
NMVYGAAAAG HRVMTASSGP GMSLKQEGIS FLAGAELPAV IVDVMRAGPG LGNIGPEQAD 

       130        140        150        160        170        180 
YNQLVKGGGH GNYRNIVLAP NSVQEMCDLT MDAFELADKY RNPVIILADA VLGQMAEPLR 

       190        200        210        220        230        240 
FPERAVEHRP DTSWAVCGSR ETMKNLVTSI FLDFDELEEF NFYLQEKYAA VEENEVRYEE 

       250        260        270        280        290        300 
YMVEDAEIVL VAYGISSRVA KSAVDTARAD GIKVGLLRPI TLFPFPSERI RELAEGGCTF 

       310        320        330        340        350 
ISVEMSSGQM REDIKMASGC RDVELVNRMG GNLIELRDIL RKIREIAGES ND 

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References

« Hide 'large scale' references
[1]"Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
J. Bacteriol. 192:5850-5851(2010) [PubMed: 20802048] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
[2]"Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum."
Tersteegen A., Linder D., Thauer R.K., Hedderich R.
Eur. J. Biochem. 244:862-868(1997) [PubMed: 9108258] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-36, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001710 Genomic DNA. Translation: ADL58685.1.
RefSeqYP_003849998.1. NC_014408.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9704799.
GenomeReviewsGene locus MTBMA_c10910 in contig CP001710_GR.
KEGGmmg:MTBMA_c10910.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMACVIVNIM.

Family and domain databases

InterProIPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00186.
PfamPF01855. POR_N. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVORB_METTM
AccessionPrimary (citable) accession number: P80908
Secondary accession number(s): D9PWT7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 30, 2010
Last modified: November 16, 2011
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program