P80905 (KORB_METTM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate synthase subunit korB
EC=1.2.7.3

Alternative name(s):
2-ketoglutarate oxidoreductase beta chain
Short name=KOR
2-oxoglutarate-ferredoxin oxidoreductase subunit beta

Gene names

Name:	korB
Ordered Locus Names:	MTBMA_c14160

Organism

Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) [Complete proteome] [HAMAP]

Taxonomic identifier

79929 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of the korA, korB, korC and korD subunits. Ref.2
Biophysicochemical properties	pH dependence: Optimum pH is 9. Ref.2 Temperature dependence: Optimum temperature is 70 degrees Celsius.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Molecular function	2-oxoglutarate synthase activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	2-oxoglutarate synthase subunit korB		PRO_0000099944

Sequences

	Sequence		Length	Mass (Da)
	P80905 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: AF2F28C7EA2DBC95	FASTA	285	31,121
	10 20 30 40 50 60 MNVKENPYLK YLRRDRLPHI FCAGCGNGIV LNTFFKGMEM AGVDFDSIAM VSGIGCSSRI 70 80 90 100 110 120 PGYVKCDSLH TTHGRPIAFA TGLKLANPSL NVVVFTGDGD AAAIGGNHLI HGARKNIDLT 130 140 150 160 170 180 VICINNSIYG MTGGQISPTS PEGSFGTTAP YGALEDPFDL SELVRAAGAS YVARWTAAHP 190 200 210 220 230 240 LQLANSIKKG LKNRGFSFIE AVSQCPTYFG RKNRMRSPVE MMKFMKENSI NRRKALKMDP 250 260 270 280 EEVEGKLIIG EFADAPRPEL CDRIYGMIEE KSGKIDIIKS AYRDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism." Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K. J. Bacteriol. 192:5850-5851(2010) [PubMed: 20802048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
[2]	"Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum." Tersteegen A., Linder D., Thauer R.K., Hedderich R. Eur. J. Biochem. 244:862-868(1997) [PubMed: 9108258] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-21, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001710 Genomic DNA. Translation: ADL59003.1.
RefSeq	YP_003850316.1. NC_014408.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9705125.
GenomeReviews	Gene locus MTBMA_c14160 in contig CP001710_GR.
KEGG	mmg:MTBMA_c14160.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MTGGQGS.
Family and domain databases
InterPro	IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K00175.
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KORB_METTM

Accession

Primary (citable) accession number: P80905
Secondary accession number(s): D9PXQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 30, 2010
Last modified:	November 16, 2011
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program