P80902 (PORC_METTM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate synthase subunit porC
EC=1.2.7.1

Alternative name(s):
Pyruvate oxidoreductase gamma chain
Short name=POR
Pyruvic-ferredoxin oxidoreductase subunit gamma

Gene names

Name:	porC
Ordered Locus Names:	MTBMA_c03160

Organism

Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) [Complete proteome] [HAMAP]

Taxonomic identifier

79929 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain. Ref.2
Biophysicochemical properties	pH dependence: Optimum pH is 10.0. Ref.2 Temperature dependence: Optimum temperature is 80 degrees Celsius.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Pyruvate synthase subunit porC		PRO_0000099912

Sequences

	Sequence		Length	Mass (Da)
	P80902 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 62A3E2099CB4986B	FASTA	177	19,147
	10 20 30 40 50 60 MIEIRFHGRG GQGAVTAAEI LAKAAFEDGK YSQAFPFFGV ERRGAPVMAF TRINDEPIRR 70 80 90 100 110 120 RYQVYNPDYV VVLDEGLVDV VDVFSGLKED GVVLLNTAGT FTSENAKIHT IDATGIALEN 130 140 150 160 170 LGRPIVNTVM LGAFAGVTGL VSIDSLIKII KETFPGKIGD KNAEAARIAY EKMKHSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism." Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K. J. Bacteriol. 192:5850-5851(2010) [PubMed: 20802048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
[2]	"Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum." Tersteegen A., Linder D., Thauer R.K., Hedderich R. Eur. J. Biochem. 244:862-868(1997) [PubMed: 9108258] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-20, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT. Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001710 Genomic DNA. Translation: ADL57922.1.
RefSeq	YP_003849235.1. NC_014408.1.
3D structure databases
ProteinModelPortal	P80902.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9704022.
GenomeReviews	Gene locus MTBMA_c03160 in contig CP001710_GR.
KEGG	mmg:MTBMA_c03160.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DYVIVQD.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
KO	K00172.
Pfam	PF01558. POR. 1 hit. [Graphical view]
SUPFAM	SSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_METTM

Accession

Primary (citable) accession number: P80902
Secondary accession number(s): D9PUM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 30, 2010
Last modified:	November 16, 2011
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program