P80892 (TRXB_VIBFI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:

trxB

Organism

Vibrio fischeri

Taxonomic identifier

668 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	45 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›45	›45	Thioredoxin reductase		PRO_0000166757
Regions
	Nucleotide binding	35 – 42	8	FAD
Experimental info
	Non-terminal residue	45	1

Sequences

	Sequence		Length	Mass (Da)
	P80892 [UniParc]. Last modified July 15, 1998. Version 1. Checksum: D0696133DE491602	FASTA	45	4,658
	10 20 30 40 MNVKHSKLLI LGSGPAGYTA AVYAARANLN PVMITGMQQG GQLTN

References

[1]	"Purification and characterization of flavoproteins and cytochromes from the yellow bioluminescence marine bacterium Vibrio fischeri strain Y1." Petushkov V.N., Lee J. Eur. J. Biochem. 245:790-796(1997) [PubMed: 9183020] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: ATCC 33715 / Y-1.
+	Additional computationally mapped references.

Cross-references

3D structure databases
ProteinModelPortal	P80892.
SMR	P80892. Positions 4-44.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
Pfam	PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00469. PNDRDTASEII.
PROSITE	PS00573. PYRIDINE_REDOX_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_VIBFI

Accession

Primary (citable) accession number: P80892

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	June 28, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program