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Protein

General stress protein 69

Gene

yhdN

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521
Active sitei57 – 571Proton donor
Active sitei84 – 841

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi204 – 21411NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBSUB:BSU09530-MONOMER.
SABIO-RKP80874.

Protein family/group databases

TCDBi8.A.5.1.4. the voltage-gated k(+) channel -subunit (kv) family.

Names & Taxonomyi

Protein namesi
Recommended name:
General stress protein 69 (EC:1.1.1.-)
Short name:
GSP69
Alternative name(s):
AKR11B
Gene namesi
Name:yhdN
Ordered Locus Names:BSU09530
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331General stress protein 69PRO_0000070388Add
BLAST

Proteomic databases

PaxDbiP80874.

Expressioni

Inductioni

By heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100005331.

Structurei

Secondary structure

1
331
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi12 – 198Combined sources
Helixi22 – 243Combined sources
Turni26 – 294Combined sources
Helixi33 – 4513Combined sources
Beta strandi50 – 523Combined sources
Helixi57 – 604Combined sources
Helixi61 – 7313Combined sources
Helixi76 – 783Combined sources
Beta strandi80 – 856Combined sources
Beta strandi87 – 926Combined sources
Beta strandi94 – 963Combined sources
Helixi100 – 11314Combined sources
Beta strandi119 – 1246Combined sources
Helixi133 – 14513Combined sources
Beta strandi148 – 1503Combined sources
Beta strandi152 – 1543Combined sources
Helixi159 – 1668Combined sources
Helixi184 – 1863Combined sources
Helixi189 – 1957Combined sources
Beta strandi199 – 2035Combined sources
Helixi207 – 2093Combined sources
Helixi226 – 2283Combined sources
Helixi231 – 2333Combined sources
Turni235 – 2373Combined sources
Helixi238 – 25619Combined sources
Helixi260 – 26910Combined sources
Beta strandi276 – 2805Combined sources
Helixi284 – 2874Combined sources
Beta strandi293 – 2953Combined sources
Helixi300 – 31314Combined sources
Helixi321 – 3233Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZ1X-ray2.20A/B1-331[»]
ProteinModelPortaliP80874.
SMRiP80874. Positions 1-331.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80874.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108FN7. Bacteria.
COG0667. LUCA.
HOGENOMiHOG000250284.
InParanoidiP80874.
OMAiIQERYSM.
OrthoDBiEOG69WFJ0.
PhylomeDBiP80874.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.

Sequencei

Sequence statusi: Complete.

P80874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYTSIADTG IEASRIGLGT WAIGGTMWGG TDEKTSIETI RAALDQGITL
60 70 80 90 100
IDTAPAYGFG QSEEIVGKAI KEYGKRDQVI LATKTALDWK NNQLFRHANR
110 120 130 140 150
ARIVEEVENS LKRLQTDYID LYQVHWPDPL VPIEETAEVM KELYDAGKIR
160 170 180 190 200
AIGVSNFSIE QMDTFRAVAP LHTIQPPYNL FEREMEESVL PYAKDNKITT
210 220 230 240 250
LLYGSLCRGL LTGKMTEEYT FEGDDLRNHD PKFQKPRFKE YLSAVNQLDK
260 270 280 290 300
LAKTRYGKSV IHLAVRWILD QPGADIALWG ARKPGQLEAL SEITGWTLNS
310 320 330
EDQKDINTIL ENTISDPVGP EFMAPPTREE I
Length:331
Mass (Da):37,312
Last modified:July 15, 1998 - v2
Checksum:i82BC24D46E4994D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → K AA sequence (PubMed:9298659).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14082 Genomic DNA. Translation: CAA74498.1.
AL009126 Genomic DNA. Translation: CAB12792.1.
PIRiD69826.
RefSeqiNP_388834.1. NC_000964.3.
WP_003245422.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB12792; CAB12792; BSU09530.
GeneIDi939270.
KEGGibsu:BSU09530.
PATRICi18973602. VBIBacSub10457_0995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14082 Genomic DNA. Translation: CAA74498.1.
AL009126 Genomic DNA. Translation: CAB12792.1.
PIRiD69826.
RefSeqiNP_388834.1. NC_000964.3.
WP_003245422.1. NZ_JNCM01000035.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZ1X-ray2.20A/B1-331[»]
ProteinModelPortaliP80874.
SMRiP80874. Positions 1-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100005331.

Protein family/group databases

TCDBi8.A.5.1.4. the voltage-gated k(+) channel -subunit (kv) family.

Proteomic databases

PaxDbiP80874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12792; CAB12792; BSU09530.
GeneIDi939270.
KEGGibsu:BSU09530.
PATRICi18973602. VBIBacSub10457_0995.

Phylogenomic databases

eggNOGiENOG4108FN7. Bacteria.
COG0667. LUCA.
HOGENOMiHOG000250284.
InParanoidiP80874.
OMAiIQERYSM.
OrthoDBiEOG69WFJ0.
PhylomeDBiP80874.

Enzyme and pathway databases

BioCyciBSUB:BSU09530-MONOMER.
SABIO-RKP80874.

Miscellaneous databases

EvolutionaryTraceiP80874.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitous hit gene."
    Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H., Venema G., Bron S.
    Microbiology 144:859-875(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis."
    Antelmann H., Bernhardt J., Schmid R., Mach H., Voelker U., Hecker M.
    Electrophoresis 18:1451-1463(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-25.
    Strain: 168 / IS58.
  4. "Structural and catalytic diversity in the two family 11 aldo-keto reductases."
    Ehrensberger A.H., Wilson D.K.
    J. Mol. Biol. 337:661-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiGS69_BACSU
AccessioniPrimary (citable) accession number: P80874
Secondary accession number(s): O07583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: February 17, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.