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P80869 (DHG2_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose 1-dehydrogenase 2
EC=1.1.1.47
Alternative name(s):
GLCDH-II
Short name=GDH-II
General stress protein 74
Short name=GSP74
Gene names
Name:ycdF
Ordered Locus Names:BSU02830
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.

Subunit structure

Homotetramer By similarity.

Induction

By heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processStress response
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionglucose 1-dehydrogenase [NAD(P)] activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Glucose 1-dehydrogenase 2
PRO_0000054617

Regions

Nucleotide binding11 – 3525NADP By similarity

Sites

Active site1591Proton acceptor By similarity
Binding site1461Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P80869 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 77842DC45D496C26

FASTA25827,776
        10         20         30         40         50         60 
MYKDLTGKTA IVTGSSKGIG KAIAERFGKE KMNVVVNYHS DPSGADETLE IIKQNGGKAV 

        70         80         90        100        110        120 
SVEADVSKEE GIQALLDTAL EHFGTLDVMV NNSGFNGVEA MPHEMSLEDW QRVIDVNVTG 

       130        140        150        160        170        180 
TFLGAKAALN HMMKNNIKGN VLNISSVHQQ IPRPVNVQYS TSKGGIKMMT ETLALNYADK 

       190        200        210        220        230        240 
GIRVNAIAPG TIATESNVDT KKEESRQKQL KKIPMKAFGK PEEVAAAAAW LVSEEASYVT 

       250 
GATLFVDGGM TLYPSQLE

« Hide

References

« Hide 'large scale' references
[1]"A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation."
Kumano M., Tamakoshi A., Yamane K.
Microbiology 143:2775-2782(1997) [PubMed: 9274031] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis."
Antelmann H., Bernhardt J., Schmid R., Mach H., Voelker U., Hecker M.
Electrophoresis 18:1451-1463(1997) [PubMed: 9298659] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-13.
Strain: 168 / IS58.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB000617 Genomic DNA. Translation: BAA22244.1.
AL009126 Genomic DNA. Translation: CAB12077.1.
PIRG69755.
RefSeqNP_388165.1. NC_000964.3.

3D structure databases

ProteinModelPortalP80869.
SMRP80869. Positions 1-256.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000004092; EBBACP00000004092; EBBACG00000004084.
GeneID938377.
GenomeReviewsGene locus BSU02830 in contig AL009126_GR.
KEGGbsu:BSU02830.
NMPDRfig|224308.1.peg.284.
PATRIC18972125. VBIBacSub10457_0291.

Organism-specific databases

GenoListBSU02830.

Phylogenomic databases

GeneTreeEBGT00070000031907.
HOGENOMHBG750976.
OMANISSVHQ.
PhylomeDBP80869.
ProtClustDBCLSK886644.

Enzyme and pathway databases

BioCycBSUB:BSU02830-MONOMER.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00034.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHG2_BACSU
AccessionPrimary (citable) accession number: P80869
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents