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Protein

Probable thiol peroxidase

Gene

tpx

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antioxidant activity. Could remove peroxides or H2O2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciBSUB:BSU29490-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thiol peroxidase (EC:1.11.1.-)
Alternative name(s):
Superoxide-inducible protein 8
Short name:
SOI8
Gene namesi
Name:tpx
Synonyms:ytgI
Ordered Locus Names:BSU29490
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 167166Probable thiol peroxidasePRO_0000187870Add
BLAST

Proteomic databases

PaxDbiP80864.

Expressioni

Inductioni

By superoxide.

Interactioni

Protein-protein interaction databases

IntActiP80864. 1 interaction.
MINTiMINT-8366928.
STRINGi224308.Bsubs1_010100016091.

Structurei

Secondary structure

1
167
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Beta strandi9 – 113Combined sources
Beta strandi13 – 153Combined sources
Beta strandi28 – 314Combined sources
Beta strandi36 – 383Combined sources
Helixi39 – 424Combined sources
Beta strandi47 – 515Combined sources
Beta strandi55 – 584Combined sources
Helixi59 – 624Combined sources
Helixi64 – 7411Combined sources
Beta strandi78 – 836Combined sources
Helixi87 – 893Combined sources
Helixi94 – 963Combined sources
Beta strandi102 – 1065Combined sources
Helixi107 – 1093Combined sources
Helixi112 – 1165Combined sources
Turni122 – 1243Combined sources
Beta strandi130 – 1345Combined sources
Beta strandi140 – 1456Combined sources
Helixi156 – 16611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JSYNMR-A1-167[»]
2JSZNMR-A1-167[»]
ProteinModelPortaliP80864.
SMRiP80864. Positions 1-167.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80864.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 167150ThioredoxinAdd
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family. Tpx subfamily.Curated
Contains 1 thioredoxin domain.Curated

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
HOGENOMiHOG000022345.
InParanoidiP80864.
KOiK11065.
OMAiKFNAQAN.
OrthoDBiEOG6NWBV8.
PhylomeDBiP80864.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITFKGGP VTLVGQEVKV GDQAPDFTVL TNSLEEKSLA DMKGKVTIIS
60 70 80 90 100
VIPSIDTGVC DAQTRRFNEE AAKLGDVNVY TISADLPFAQ ARWCGANGID
110 120 130 140 150
KVETLSDHRD MSFGEAFGVY IKELRLLARS VFVLDENGKV VYAEYVSEAT
160
NHPNYEKPIE AAKALVK
Length:167
Mass (Da):18,216
Last modified:January 23, 2007 - v3
Checksum:i5B2BD8169C0555C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00316.1.
AL009126 Genomic DNA. Translation: CAB14927.1.
PIRiF69992.
RefSeqiNP_390827.1. NC_000964.3.
WP_003223506.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14927; CAB14927; BSU29490.
GeneIDi11240542.
937688.
KEGGibsu:BSU29490.
PATRICi18977800. VBIBacSub10457_3088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00316.1.
AL009126 Genomic DNA. Translation: CAB14927.1.
PIRiF69992.
RefSeqiNP_390827.1. NC_000964.3.
WP_003223506.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JSYNMR-A1-167[»]
2JSZNMR-A1-167[»]
ProteinModelPortaliP80864.
SMRiP80864. Positions 1-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP80864. 1 interaction.
MINTiMINT-8366928.
STRINGi224308.Bsubs1_010100016091.

Proteomic databases

PaxDbiP80864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14927; CAB14927; BSU29490.
GeneIDi11240542.
937688.
KEGGibsu:BSU29490.
PATRICi18977800. VBIBacSub10457_3088.

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
HOGENOMiHOG000022345.
InParanoidiP80864.
KOiK11065.
OMAiKFNAQAN.
OrthoDBiEOG6NWBV8.
PhylomeDBiP80864.

Enzyme and pathway databases

BioCyciBSUB:BSU29490-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP80864.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
    Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
    Microbiology 143:3431-3441(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis."
    Antelmann H., Bernhardt J., Schmid R., Mach H., Voelker U., Hecker M.
    Electrophoresis 18:1451-1463(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-32.
    Strain: 168 / IS58.

Entry informationi

Entry nameiTPX_BACSU
AccessioniPrimary (citable) accession number: P80864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.