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Protein

Probable thiol peroxidase

Gene

tpx

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antioxidant activity. Could remove peroxides or H2O2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciBSUB:BSU29490-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thiol peroxidase (EC:1.11.1.-)
Alternative name(s):
Superoxide-inducible protein 8
Short name:
SOI8
Gene namesi
Name:tpx
Synonyms:ytgI
Ordered Locus Names:BSU29490
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001878702 – 167Probable thiol peroxidaseAdd BLAST166

Proteomic databases

PaxDbiP80864.
PRIDEiP80864.

Expressioni

Inductioni

By superoxide.

Interactioni

Protein-protein interaction databases

IntActiP80864. 1 interactor.
MINTiMINT-8366928.
STRINGi224308.Bsubs1_010100016091.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi9 – 11Combined sources3
Beta strandi13 – 15Combined sources3
Beta strandi28 – 31Combined sources4
Beta strandi36 – 38Combined sources3
Helixi39 – 42Combined sources4
Beta strandi47 – 51Combined sources5
Beta strandi55 – 58Combined sources4
Helixi59 – 62Combined sources4
Helixi64 – 74Combined sources11
Beta strandi78 – 83Combined sources6
Helixi87 – 89Combined sources3
Helixi94 – 96Combined sources3
Beta strandi102 – 106Combined sources5
Helixi107 – 109Combined sources3
Helixi112 – 116Combined sources5
Turni122 – 124Combined sources3
Beta strandi130 – 134Combined sources5
Beta strandi140 – 145Combined sources6
Helixi156 – 166Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JSYNMR-A1-167[»]
2JSZNMR-A1-167[»]
ProteinModelPortaliP80864.
SMRiP80864.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80864.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 167ThioredoxinAdd BLAST150

Sequence similaritiesi

Belongs to the AhpC/TSA family. Tpx subfamily.Curated
Contains 1 thioredoxin domain.Curated

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
HOGENOMiHOG000022345.
InParanoidiP80864.
KOiK11065.
OMAiKFNAQAN.
PhylomeDBiP80864.

Family and domain databases

CDDicd03014. PRX_Atyp2cys. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx. 1 hit.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITFKGGP VTLVGQEVKV GDQAPDFTVL TNSLEEKSLA DMKGKVTIIS
60 70 80 90 100
VIPSIDTGVC DAQTRRFNEE AAKLGDVNVY TISADLPFAQ ARWCGANGID
110 120 130 140 150
KVETLSDHRD MSFGEAFGVY IKELRLLARS VFVLDENGKV VYAEYVSEAT
160
NHPNYEKPIE AAKALVK
Length:167
Mass (Da):18,216
Last modified:January 23, 2007 - v3
Checksum:i5B2BD8169C0555C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00316.1.
AL009126 Genomic DNA. Translation: CAB14927.1.
PIRiF69992.
RefSeqiNP_390827.1. NC_000964.3.
WP_003223506.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14927; CAB14927; BSU29490.
GeneIDi11240542.
937688.
KEGGibsu:BSU29490.
PATRICi18977800. VBIBacSub10457_3088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008220 Genomic DNA. Translation: AAC00316.1.
AL009126 Genomic DNA. Translation: CAB14927.1.
PIRiF69992.
RefSeqiNP_390827.1. NC_000964.3.
WP_003223506.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JSYNMR-A1-167[»]
2JSZNMR-A1-167[»]
ProteinModelPortaliP80864.
SMRiP80864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP80864. 1 interactor.
MINTiMINT-8366928.
STRINGi224308.Bsubs1_010100016091.

Proteomic databases

PaxDbiP80864.
PRIDEiP80864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14927; CAB14927; BSU29490.
GeneIDi11240542.
937688.
KEGGibsu:BSU29490.
PATRICi18977800. VBIBacSub10457_3088.

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
HOGENOMiHOG000022345.
InParanoidiP80864.
KOiK11065.
OMAiKFNAQAN.
PhylomeDBiP80864.

Enzyme and pathway databases

BioCyciBSUB:BSU29490-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP80864.

Family and domain databases

CDDicd03014. PRX_Atyp2cys. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx. 1 hit.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPX_BACSU
AccessioniPrimary (citable) accession number: P80864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.