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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Probable fructose-bisphosphate aldolase (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Proton donorBy similarity1
Active sitei311By similarity1
Active sitei425By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciBSUB:BSU31350-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Vegetative protein 54
Short name:
VEG54
Gene namesi
Name:pgi
Synonyms:yugL
Ordered Locus Names:BSU31350
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001805932 – 450Glucose-6-phosphate isomeraseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP80860
PRIDEiP80860

PTM databases

iPTMnetiP80860

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP80860, 1 interactor
MINTiP80860
STRINGi224308.Bsubs1_010100017041

Structurei

3D structure databases

ProteinModelPortaliP80860
SMRiP80860
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
InParanoidiP80860
KOiK01810
OMAiSFIIPDD
PhylomeDBiP80860

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 2 hits
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHVRFDYSK ALTFFNEHEL TYLRDFVKTA HHNIHEKTGA GSDFLGWVDL
60 70 80 90 100
PEHYDKEEFA RIKKSAEKIK SDSDVLLVVG IGGSYLGARA AIEALNHAFY
110 120 130 140 150
NTLPKAKRGN PQVIFIGNNI SSSYMRDVMD LLEDVDFSIN VISKSGTTTE
160 170 180 190 200
PAIAFRIFRK LLEEKYGKEE AKARIYATTD KERGALKTLS NEEGFESFVI
210 220 230 240 250
PDDVGGRYSV LTAVGLLPIA VSGVNIDDMM KGALDASKDF ATSELEDNPA
260 270 280 290 300
YQYAVVRNVL YNKGKTIEML INYEPALQYF AEWWKQLFGE SEGKDEKGIY
310 320 330 340 350
PSSANYSTDL HSLGQYVQEG RRDLFETVLN VEKPKHELTI EEADNDLDGL
360 370 380 390 400
NYLAGKTVDF VNKKAFQGTM LAHTDGNVPN LIVNIPELNA YTFGYLVYFF
410 420 430 440 450
EKACAMSGYL LGVNPFDQPG VEAYKVNMFA LLGKPGFEEK KAELEKRLED
Length:450
Mass (Da):50,543
Last modified:May 26, 2009 - v4
Checksum:iDAAA87AFB81E1DA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 9FDYS → LTTP in CAB07930 (PubMed:9274030).Curated4
Sequence conflicti16N → PT in CAB07930 (PubMed:9274030).Curated1
Sequence conflicti63K → Q in CAB07930 (PubMed:9274030).Curated1
Sequence conflicti70K → Q in CAB07930 (PubMed:9274030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93936 Genomic DNA Translation: CAB07930.1
AL009126 Genomic DNA Translation: CAB15124.2
PIRiB69675
RefSeqiNP_391013.2, NC_000964.3
WP_003243401.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15124; CAB15124; BSU31350
GeneIDi937165
KEGGibsu:BSU31350
PATRICifig|224308.179.peg.3399

Similar proteinsi

Entry informationi

Entry nameiG6PI_BACSU
AccessioniPrimary (citable) accession number: P80860
Secondary accession number(s): O08330
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: February 28, 2018
This is version 124 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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